scholarly journals Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tadashi Shiohama ◽  
Aya Hisada ◽  
Midori Yamamoto ◽  
Kenichi Sakurai ◽  
Rieko Takatani ◽  
...  
Keyword(s):  
Cohort Study ◽  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy ◽  
Exposure During Pregnancy ◽  
Smoking Group ◽  
The Impact

AbstractMaternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated the impact of maternal tobacco exposure on their offspring’s HC and the relationship with placental weight ratio (PWR) and placental abnormalities. Parents-children pairs (n = 84,856) were included from the 104,065 records of the Japan Environmental and Children’s Study. Maternal perinatal clinical and social information by self-administered questionnaires, offspring’s body size, and placental information were collected. Data were analyzed with binominal logistic regression analysis and path analysis. Logistic regression showed significantly elevated adjusted odds ratio (aOR) (1.653, 95% CI 1.387–1.969) for the impact of maternal smoking during pregnancy on their offspring’s smaller HC at birth. Maternal exposure to environmental tobacco smoke in the non-smoking group did not increase aOR for the smaller HC. Path analysis showed that maternal smoking during pregnancy decreased the offspring’s HC directly, but not indirectly via PWR or placental abnormalities. The quitting smoking during pregnancy group did not increase aOR for the smaller HC than the non-smoking group, suggesting that quitting smoking may reduce their offspring’s neurological impairment even after pregnancy.

scholarly journals Tobacco smoke exposure in early life and adolescence in relation to lung function

2018 ◽  
Vol 51 (6) ◽  
pp. 1702111 ◽  
Author(s):  
Jesse D. Thacher ◽  
Erica S. Schultz ◽  
Jenny Hallberg ◽  
Ulrika Hellberg ◽  
Inger Kull ◽  
...  
Keyword(s):  
Lung Function ◽  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Airway Resistance ◽  
Adolescent Smoking ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy ◽  
The Impact

Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of −1.1% (95% CI −2.0 to −0.2%). IOS demonstrated greater resistance at 5–20 Hz (R5–20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of −0.9% (95% CI −1.8 to −0.1%) and increased resistance of 6.5 Pa·L–1·s (95% CI 0.7 to 12.2 Pa·L–1·s) in R5–20. Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL−1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.

scholarly journals The Impact of Tobacco Smoke Exposure on Wheezing and Overweight in 4–6-Year-Old Children

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Regina Grazuleviciene ◽  
Sandra Andrusaityte ◽  
Inga Uzdanaviciute ◽  
Jolanta Kudzyte ◽  
Rimantas Kevalas ◽  
...  
Keyword(s):  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Maternal Education ◽  
Synergetic Effect ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Targeted Interventions ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy ◽  
The Impact

Aim. To investigate the association between maternal smoking during pregnancy, second-hand tobacco smoke (STS) exposure, education level, and preschool children’s wheezing and overweight.Methods. This cohort study used data of the KANC cohort—1,489 4–6-year-old children from Kaunas city, Lithuania. Multivariate logistic regression was employed to study the influence of prenatal and postnatal STS exposure on the prevalence of wheezing and overweight, controlling for potential confounders.Results. Children exposed to maternal smoking during pregnancy had a slightly increased prevalence of wheezing and overweight. Postnatal exposure to STS was associated with a statistically significantly increased risk of wheezing and overweight in children born to mothers with lower education levels (OR 2.12; 95% CI 1.04–4.35 and 3.57; 95% CI 1.76–7.21, accordingly).Conclusions. The present study findings suggest that both maternal smoking during pregnancy and STS increase the risk of childhood wheezing and overweight, whereas lower maternal education might have a synergetic effect. Targeted interventions must to take this into account and address household smoking.

scholarly journals The impact of maternal smoking during pregnancy on depressive and anxiety behaviors in children: the Norwegian Mother and Child Cohort Study

BMC Medicine ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Steven Moylan ◽  
Kristin Gustavson ◽  
Simon Øverland ◽  
Evalill Bølstad Karevold ◽  
Felice N Jacka ◽  
...  
Keyword(s):  
Cohort Study ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Mother And Child ◽  
Maternal Smoking During Pregnancy ◽  
The Impact

scholarly journals Ενδομήτρια έκθεση στον καπνό του τσιγάρου, κίνδυνος εκδήλωσης σχιζοφρένειας και βαρύτητα αρνητικών/θετικών συμπτωμάτων

2003 ◽  
Author(s):  
Αναστασία Σταθοπούλου
Keyword(s):  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Negative Symptoms ◽  
Tobacco Smoke Exposure ◽  
Unique Contribution ◽  
Smoking During Pregnancy ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy ◽  
Paternal Smoking ◽  
Normal Controls

Prenatal exposure to cigarette smoke causes chronic fetal hypoxia, dysregulation of endocrineequilibrium, and disruption of fetal neurodevelopment associated with brain malfunction, all of whichpotentially could induce vulnerability to schizophrenia. A total of 212 schizophrenia patients aged 14-30 years, and 212 matched controls were studied. Prenatal tobacco smoke exposure of theschizophrenia patients was compared to that of the normal controls by applying logistic regressionanalysis and controlling for several confounding factors The outcomes of interest were comparison ofthe frequency of maternal and paternal smoking between patients and controls as well as the severity ofpositive and negative symptoms between the offspring of smoking and nonsmoking parents.Furthermore, we investigated the relative frequency of subtypes of schizophrenia among offspring ofsmoking and non-smoking parent. Among the mothers of schizophrenia patients and controls, 92(43.4%) and 46 (21.7%) smoked, respectively. Maternal smoking during pregnancy had a significantunique contribution on increasing the risk for development of schizophrenia (p=0.001), and a greaterseverity of negative symptoms (p=0.023). Simultaneously, logistic regression analysis showed thatmaternal smoking during pregnancy had significantly unique contribution to increased risk for thedevelopment of schizophrenia with possible ratio = 2.32, 95% CI = 1.41-3.81, p = 0.001 and frequencyof non-paranoid subtypes as potential ratio = 2.94,95% CI = 1.50-5.76, p = 0.002. Paternal smokingdid not have a significant effect on the risk of schizophrenia, or severity of negative symptoms. Thefindings suggest that maternal smoking during pregnancy puts offspring at an increased risk for laterschizophrenia, with increased severity of negative symptoms. Given the wide practice of smokingduring pregnancy, fetal exposure to tobacco smoke could be a major preventable neurodevelopmentalfactor that increases vulnerability to schizophrenia.

Assessment of prenatal tobacco smoke exposure by determining nicotine and its metabolites in meconium

2007 ◽  
Vol 26 (6) ◽  
pp. 535-544 ◽  
Author(s):  
E. Köhler ◽  
S. Avenarius ◽  
A. Rabsilber ◽  
C. Gerloff ◽  
G. Jorch
Keyword(s):  
Tobacco Smoke ◽  
Maternal Smoking ◽  
High Performance ◽  
Smoking Status ◽  
Hplc Method ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Quit Smoking

Meconium samples collected from 115 neonates were analysed for nicotine, cotinine and trans -3-hydroxycotinine (OH-cotinine) by means of high-performance liquid chromatography (HPLC) to identify prenatal smoke exposure. The self-reported maternal smoking status during pregnancy was determined by means of a questionnaire and verified by measurements in urine prior to childbirth. The total sum of nicotine and its metabolites (Sumtot) of the first passed meconium samples was 1560 ± 1024 pmol/g in newborns of smoking mothers. Smoking of less than five cigarettes was clearly detected. Sumtot remained constant in all meconium samples passed by a neonate in succession. However, the proportion of nicotine decreased with the time of passage after birth and the OH-cotinine proportion increased, whereas cotinine hardly changed. Nicotine or its metabolites were not detectable in meconium (detection limit < 20 pmol/g), when the mothers were only exposed to environmental tobacco smoke (ETS) using the HPLC method. The hypothesis that the content of nicotine metabolites in meconium reflects long-term smoke exposure could not be confirmed in newborns whose mothers had quit smoking during the latter half of pregnancy. Determining Sumtot enables the intensity of continuous smoking during pregnancy to be estimated in all meconium samples passed by a newborn. Human & Experimental Toxicology (2007) 26: 535—544

scholarly journals Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study

2018 ◽  
Vol 188 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Nis Brix ◽  
Andreas Ernst ◽  
Lea L B Lauridsen ◽  
Erik T Parner ◽  
Jørn Olsen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Maternal Smoking ◽  
Population Based ◽  
Smoking During Pregnancy ◽  
Timing Of Puberty ◽  
Maternal Smoking During Pregnancy

scholarly journals Indoor air pollution and tobacco smoke exposure: impact on nasopharyngeal bacterial carriage in mothers and infants in an African birth cohort study

2019 ◽  
Vol 5 (1) ◽  
pp. 00052-2018 ◽  
Author(s):  
Aneesa Vanker ◽  
Polite M. Nduru ◽  
Whitney Barnett ◽  
Felix S. Dube ◽  
Peter D. Sly ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Study ◽  
Particulate Matter ◽  
Indoor Air ◽  
Tobacco Smoke ◽  
Indoor Air Pollution ◽  
Bacterial Species ◽  
Tobacco Smoke Exposure ◽  
Nasopharyngeal Carriage ◽  
The Impact

Indoor air pollution (IAP) or environmental tobacco smoke (ETS) exposure may influence nasopharyngeal carriage of bacterial species and development of lower respiratory tract infection (LRTI). The aim of this study was to longitudinally investigate the impact of antenatal or postnatal IAP/ETS exposure on nasopharyngeal bacteria in mothers and infants.A South African cohort study followed mother–infant pairs from birth through the first year. Nasopharyngeal swabs were taken at birth, 6 and 12 months for bacterial culture. Multivariable and multivariate Poisson regression investigated associations between nasopharyngeal bacterial species and IAP/ETS. IAP exposures (particulate matter, carbon monoxide, nitrogen dioxide, volatile organic compounds) were measured at home visits. ETS exposure was measured through maternal and infant urine cotinine. Infants received the 13-valent pneumococcal andHaemophilus influenzaeB conjugate vaccines.There were 881 maternal and 2605 infant nasopharyngeal swabs. Antenatal ETS exposure was associated withStreptococcus pneumoniaecarriage in mothers (adjusted risk ratio (aRR) 1.73 (95% CI 1.03–2.92)) while postnatal ETS exposure was associated with carriage in infants (aRR 1.14 (95% CI 1.00–1.30)) Postnatal particulate matter exposure was associated with the nasopharyngeal carriage ofH. influenzae(aRR 1.68 (95% CI 1.10– 2.57)) orMoraxella catarrhalis(aRR 1.42 (95% CI 1.03–1.97)) in infants.Early-life environmental exposures are associated with an increased prevalence of specific nasopharyngeal bacteria during infancy, which may predispose to LRTI.

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