scholarly journals Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Eric Jorgenson ◽  
Hélène Choquet ◽  
Jie Yin ◽  
Thomas J. Hoffmann ◽  
Yambazi Banda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Pigmentation ◽  
Sun Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Genetic Ancestry ◽  
European Ancestry ◽  
History Of ◽  
Hispanic Latinos

AbstractAlthough cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in individuals of European ancestry, the incidence of cSCC in Hispanic/Latinos is also increasing. cSCC has both a genetic and environmental etiology. Here, we examine the role of genetic ancestry, skin pigmentation, and sun exposure in Hispanic/Latinos and non-Hispanic whites on cSCC risk. We observe an increased cSCC risk with greater European ancestry (P = 1.27 × 10−42) within Hispanic/Latinos and with greater northern (P = 2.38 × 10−65) and western (P = 2.28 × 10−49) European ancestry within non-Hispanic whites. These associations are significantly, but not completely, attenuated after considering skin pigmentation-associated loci, history of actinic keratosis, and sun-protected versus sun-exposed anatomical sites. We also report an association of the well-known pigment variant Ala111Thr (rs1426654) at SLC24A5 with cSCC in Hispanic/Latinos. These findings demonstrate a strong correlation of northwestern European genetic ancestry with cSCC risk in both Hispanic/Latinos and non-Hispanic whites, largely but not entirely mediated through its impact on skin pigmentation.

Metastasis of cutaneous squamous cell carcinoma to the stomach: a rare entity

2020 ◽  
Vol 13 (11) ◽  
pp. e238731
Author(s):  
Marica Reise-Filteau ◽  
Michael Carter ◽  
Ryan DeCoste ◽  
Ali Kohansal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Functional Decline ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Rare Entity ◽  
Gastric Tumour ◽  
Comprehensive Genomic Profiling ◽  
History Of ◽  
The Right

Metastatic spread of cutaneous squamous cell carcinoma (cSCC) to the gastrointestinal tract is a rare entity. A 63-year-old woman with a history of poorly controlled HIV and a recurrent cSCC on the right temple presented with functional decline, ascites and shortness of breath. A CT scan showed widespread metastatic malignancy involving lung, pleura, heart, stomach, liver, retroperitoneum and soft-tissue. In the case presented here, an upper endoscopy revealed a submucosal lesion in the stomach. Biopsies described the lesion as a poorly differentiated SCC. Comprehensive genomic profiling yielded striking molecular similarities between the gastric tumour and the patient’s prior cSCC. It confirmed the origin of the disease and excluded spread from an occult primary. This case adds to the limited literature on gastrointestinal metastases of cSCC and serves as a reminder that non-AIDS-defining cancers are on the rise in the HIV-population.

Skin Cancer Knowledge and Preventive Behaviors among Patients with a Recent History of Cutaneous Squamous Cell Carcinoma

Dermatology ◽  
2008 ◽  
Vol 217 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Cristina Renzi ◽  
Simona Mastroeni ◽  
Thomas J. Mannooranparampil ◽  
Francesca Passarelli ◽  
Alessio Caggiati ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Recent History ◽  
Cancer Knowledge ◽  
Preventive Behaviors ◽  
History Of

scholarly journals Mortality in cancer patients with a history of cutaneous squamous cell carcinoma - a nationwide population-based cohort study

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Sigrun Alba Johannesdottir ◽  
Timothy L Lash ◽  
Annette Østergaard Jensen ◽  
Dóra Körmendiné Farkas ◽  
Anne Braae Olesen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cohort Study ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Population Based ◽  
Cutaneous Squamous Cell Carcinoma ◽  
History Of

scholarly journals Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Erin M. Burns ◽  
Kathleen L. Tober ◽  
Judith A. Riggenbach ◽  
Donna F. Kusewitt ◽  
Gregory S. Young ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Sun Exposure ◽  
Epidemiological Studies ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Exposure Model ◽  
Uvb Exposure

Epidemiological studies support a link between cumulative sun exposure and cutaneous squamous cell carcinoma (SCC) development. However, the presumed effects of extended ultraviolet light B (UVB) exposure on tumorigenesis in the sexes have not been formally investigated. We examined differences in ultimate tumorigenesis at 25 weeks in mice exposed to UVB for either 10 or 25 weeks. Additionally, we investigated the effect of continued UVB exposure on the efficacy of topical treatment with anti-inflammatory (diclofenac) or antioxidant (C E Ferulic or vitamin E) compounds on modulating tumorigenesis. Vehicle-treated mice in the 25-week UVB exposure model exhibited an increased tumor burden and a higher percentage of malignant tumors compared to mice in the 10-week exposure model, which correlated with increases in total and mutant p53-positive epidermal cells. Only topical diclofenac decreased tumor number and burden in both sexes regardless of UVB exposure length. These data support the commonly assumed but not previously demonstrated fact that increased cumulative UVB exposure increases the risk of UVB-induced SCC development and can also affect therapeutic efficacies. Our study suggests that cessation of UVB exposure by at-risk patients may decrease tumor development and that topical NSAIDs such as diclofenac may be chemopreventive.

scholarly journals Arsenicosis Presenting with Cutaneous Squamous Cell Carcinoma: A Case Report

2019 ◽  
Vol 53 (2) ◽  
Author(s):  
Marie Len A. Camaclang ◽  
Eileen Liesl A. Cubillan ◽  
Claudine Yap-Silva
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Arsenic Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Source Control ◽  
Arsenic Level ◽  
Chronic Arsenic Exposure ◽  
History Of ◽  
Control And Management

A 29-year-old male with eleven-year history of hyperkeratotic papules and speckled pigmentation developed cutaneous squamous cell carcinoma. Arsenicosis was confirmed by elevated hair arsenic level, and histopathologic findings of arsenical keratosis and one lesion showing carcinoma-in-situ. Chronic arsenic exposure has been found to activate inflammatory and carcinogenic pathways leading to development of pre-malignant and malignant lesions. A multi-disciplinary approach involving healthcare specialists and environmentalists is crucial in source control and management of long-term complications.

scholarly journals Giant squamous cell carcinoma of the scalp

2022 ◽  
Vol 13 (1) ◽  
pp. 99-100
Author(s):  
Soumaya Hamich ◽  
Fatima Zahra El Gaitibi ◽  
Kaoutar Znati ◽  
Meriem Meziane ◽  
Nadia Ismaili ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Low Socioeconomic Status ◽  
Sun Exposure ◽  
Biological Assessment ◽  
Personal Hygiene ◽  
Surgical Removal ◽  
Anatomical Location ◽  
History Of

We report the case of a 43-year-old male with a history of pulmonary tuberculosis cured one year previously and a 25-year-old history of smoking. The patient presented with a tumor of the scalp that had been evolving since the age of thirteen years, gradually increasing in size, neglected by the patient. An examination revealed a giant tumor of the occipital area (Fig. 1), 15 × 8 cm in size, which was protruded and ulcerated, with thick, hard edges. On biological assessment, a hemogram revealed microcytic hypochromic anemia at 2.9 g/dL. Ferritin was at 4 ng/mL. HIV serology was negative. A skin biopsy revealed a mature, well-differentiated, infiltrating squamous cell carcinoma (Fig. 2). A CT scan of the brain revealed a poorly limited subgalactic parietooccipital lesion process, with bone lysis and endocranial extension and invasion of the upper longitudinal sinus. Ultrasonography of the lymph node area revealed bilateral axillary and inguinal adenopathies with an infracentimetric fatty hilum. The immediate management was to transfuse the patient with three red blood cells. Control hemoglobin was 7.7 g/dl. The patient, then, received external radiotherapy but was lost to follow-up. Squamous cell carcinoma is the second most common skin cancer [1], occurring in elderly patients with a clear phototype on sun-exposed areas. Its frequency is increasing and correlates with sun exposure [1]. It may reach enormous sizes if neglected and not treated in its early stages. The most common causes of a delayed diagnosis are low socioeconomic status, poor personal hygiene, and fear of the diagnosis and of its possible consequences [2]. Giant carcinomas are defined by a diameter exceeding 5 cm [3]. They pose a higher risk of complication and mortality. The invasiveness of these tumors depends on the size, anatomical location, and histological subtype. Their treatment is difficult because, even with extensive surgical removal, recurrence and metastasis are frequent [3].

scholarly journals Case Report: Cetuximab use in advanced cutaneous squamous cell carcinoma resistant to chemotherapy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 933
Author(s):  
Alvise Sernicola ◽  
Salvatore Lampitelli ◽  
Sara Grassi ◽  
Antonio Giovanni Richetta ◽  
Stefano Calvieri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Whole Body ◽  
Whole Body Ct ◽  
Progression Of Disease ◽  
History Of ◽  
Epidermal Growth

We present the case of a 60-year-old man with unresectable cutaneous squamous cell carcinoma (cSCC) of the sternal area, which was not amenable to radiation therapy. The treatment history of this patient is remarkable as the disease had progressed through all lines of conventional therapy established in the literature. We decided to initiate treatment with epidermal growth factor receptor (EGFR) inhibitor cetuximab and we reassessed the patient after 12 weeks with a whole-body CT scan, documenting stability in the size and radiologic features of the disease. Cetuximab, like all current treatments for advanced cSCC, is administered off-label and proved effective in preventing further progression of disease in our patient.

scholarly journals Presence of Human Papillomavirus DNA in Plucked Eyebrow Hairs Is Associated with a History of Cutaneous Squamous Cell Carcinoma

2003 ◽  
Vol 121 (6) ◽  
pp. 1531-1535 ◽  
Author(s):  
Linda Struijk ◽  
Jan Nico Bouwes Bavinck ◽  
Patrick Wanningen ◽  
Els Van der meijden ◽  
Rudi G.J. Westendorp ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
History Of ◽  
Papillomavirus Dna
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