Rho-associated coiled-coil containing protein kinase 2 (ROCK2)

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine-threonine kinase, whose inhibitors are useful for the regulation of actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole...

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MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells

Molecular Medicine Reports ◽

10.3892/mmr.2015.3937 ◽

2015 ◽

Vol 12 (3) ◽

pp. 4554-4559 ◽

Cited By ~ 10

Author(s):

JIANJUN HUANG ◽

YING SHI ◽

HUI LI ◽

MEISONGZHU YANG ◽

GUOHONG LIU

Keyword(s):

Protein Kinase ◽

Tumor Suppressor ◽

Coiled Coil ◽

Osteosarcoma Cells

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Effectiveness of Ripasudil, a Rho-Associated Coiled/Coil-Containing Protein Kinase Inhibitor, in Improving Retinoschisis and Cystic-Like Foveal Cavities in Eyes with X-Linked Retinoschisis

Case Reports in Ophthalmology ◽

10.1159/000509261 ◽

2020 ◽

Vol 11 (2) ◽

pp. 411-417

Author(s):

Hitomi Suimon ◽

Masahiko Sugimoto ◽

Hisashi Matsubara ◽

Mineo Kondo

Keyword(s):

Protein Kinase ◽

Chart Review ◽

Kinase Inhibitor ◽

Coiled Coil ◽

Clinical Information ◽

Rock Inhibitor ◽

First Case ◽

Juvenile Retinoschisis ◽

Successful Resolution ◽

Visual Disturbances

This is the first reported case of a successful resolution of cystic-like foveal cavities in eyes with X-linked juvenile retinoschisis (XLRS) treated with topical ripasudil hydrochloride hydrate, a Rho-associated coiled/coil-containing protein kinase (ROCK) inhibitor. A chart review was performed on 1 patient to collect all relevant clinical information and the optical coherence tomographic (OCT) images. A healthy 18-year-old young man presented with bilateral visual disturbances. The patient was diagnosed with XLRS from the spoke-wheel pattern around the macula, negative electroretinograms, and retinoschisis with cystic-like foveal cavities in the OCT images. Significant reductions of the retinoschisis and cystic-like cavities were observed after treatment with topical ripasudil. This is the first case of XLRS that had a resolution of cystic-like foveal cavities after topical ripasudil, a ROCK inhibitor. Since many XLRS patients have a worsening of their visual acuities due to the progressive nature of retinoschisis and cystic-like foveal cavities, topical ripasudil offers a potential treatment option.

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Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.111.182600 ◽

2011 ◽

Vol 339 (3) ◽

pp. 746-756 ◽

Cited By ~ 13

Author(s):

Melissa Moey ◽

Venkatesh Rajapurohitam ◽

Asad Zeidan ◽

Morris Karmazyn

Keyword(s):

Protein Kinase ◽

Coiled Coil ◽

Mitogen Activated Protein Kinase ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor ◽

Pathway Activation ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Response to Letters Regarding Article, “Evidence for Statin Pleiotropy in Humans: Differential Effects of Statins and Ezetimibe on Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Endothelial Function, and Inflammation”

Circulation ◽

10.1161/circulationaha.109.863399 ◽

2009 ◽

Vol 120 (9) ◽

Cited By ~ 1

Author(s):

Ping-Yen Liu ◽

James K. Liao ◽

Yen-Wen Liu ◽

Li-Jen Lin ◽

Jyh-Hong Chen

Keyword(s):

Protein Kinase ◽

Endothelial Function ◽

Kinase Activity ◽

Coiled Coil ◽

Protein Kinase Activity ◽

Differential Effects

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MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics ◽

10.3727/096504017x14974343584989 ◽

2018 ◽

Vol 26 (3) ◽

pp. 411-420 ◽

Cited By ~ 14

Author(s):

Yanli Wang ◽

Jia Li ◽

Chunling Xu ◽

Xiaomeng Zhang

Keyword(s):

Ovarian Cancer ◽

Protein Kinase ◽

Coiled Coil ◽

Figo Stage ◽

Inhibitory Effect ◽

In Vivo Studies ◽

Luciferase Reporter ◽

Migration And Invasion ◽

Poor Overall Survival

Increasing evidence indicates that the dysregulation of microRNAs is associated with the development and progression of various cancers. MicroRNA-139-5p (miR-139-5p) has been reported to have a tumor suppressive role in many types of cancers. The role of miR-139-5p in ovarian cancer (OC) is poorly understood. The purpose of the present study was to explore the expression of miR-139-5p and its function in OC. The results showed that miR-139-5p expression was markedly downregulated in OC tissues and cell lines. In addition, underexpression of miR-139-5p was significantly associated with FIGO stage, lymph mode metastasis, and poor overall survival of OC patients. Functional analyses indicated that overexpression of miR-139-5p significantly inhibited proliferation, colony formation, migration, and invasion of OC cells. Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) was identified as a direct target of miR-139-5p using luciferase reporter assays, qualitative real-time reverse transcriptase PCR (qRT-PCR), and Western blot. In addition, ROCK2 expression was upregulated and was inversely correlated with miR-139-5p levels in OC tissues. Rescue experiments showed that overexpression of ROCK2 effectively reversed the inhibitory effect of OC cells induced by miR-139-5p. Most interestingly, in vivo studies indicated that miR-139-5p markedly suppressed the growth of tumors by repressing ROCK2 expression in nude mice. Taken together, these findings demonstrated that miR-139-5p plays an important tumor suppressor role in OC by directly binding to ROCK2, providing a novel target for the molecular treatment of OC.

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