Age- and gender-dependent association of the –344C/T polymorphism of CYP11B2 with blood pressure in European populations

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

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4.3 IMPACT OF AGE AND GENDER ON THE HAEMODYNAMIC DETERMINANTS OF BLOOD PRESSURE ACROSS THE ADULT AGE-SPAN

Artery Research ◽

10.1016/j.artres.2014.09.071 ◽

2014 ◽

Vol 8 (4) ◽

pp. 127

Author(s):

A. Cocks ◽

J. Smith ◽

J. Woodcock-Smith ◽

K. Miles ◽

K. Maki-Petaja ◽

...

Keyword(s):

Blood Pressure ◽

Age And Gender ◽

Adult Age ◽

And Gender

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Effects of age and gender on ambulatory blood pressure and heart rate

Journal of Human Hypertension ◽

10.1038/sj.jhh.1000592 ◽

1998 ◽

Vol 12 (4) ◽

pp. 253-257 ◽

Cited By ~ 15

Author(s):

F Jaquet ◽

IB Goldstein ◽

D Shapir

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Ambulatory Blood Pressure ◽

Age And Gender ◽

And Gender

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Blood Pressure and Immunoglobulins

Clinical Science ◽

10.1042/cs0650665 ◽

1983 ◽

Vol 65 (6) ◽

pp. 665-667 ◽

Cited By ~ 2

Author(s):

A. M. De Bruijn ◽

F. C. A. Geers ◽

R. S. A. J. Hylkema ◽

R. Vermeeren ◽

A. Hofman

Keyword(s):

Blood Pressure ◽

General Population ◽

Serum Concentrations ◽

Age And Gender ◽

Normotensive Subjects ◽

And Gender

1. Serum concentrations of IgG and IgM were measured in 87 hypertensive and 87 normotensive subjects, matched for age and gender, and selected from the same general population. 2. No significant differences between these two groups were found, in contrast to some previous reports. 3. The reasons for this discrepancy are discussed.

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Maximal Treadmill Exercise Blood Pressure by Age and Gender

Journal of Cardiopulmonary Rehabilitation ◽

10.1097/00008483-199003000-00013 ◽

1990 ◽

Vol 10 (3) ◽

pp. 108

Author(s):

T G Allison ◽

R W Squires ◽

G T Gau

Keyword(s):

Blood Pressure ◽

Treadmill Exercise ◽

Age And Gender ◽

Exercise Blood Pressure ◽

And Gender

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The Relationship between Under-Nutrition and Hypertension among Ellisras Children and Adolescents Aged 9 to 17 Years

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17238926 ◽

2020 ◽

Vol 17 (23) ◽

pp. 8926

Author(s):

Tumisho Praise Mphahlele ◽

Kotsedi Daniel Monyeki ◽

Winnie Maletladi Dibakwane ◽

Sekgothe Mokgoatšana

Keyword(s):

Blood Pressure ◽

Reference Population ◽

Linear Regression Models ◽

Upper Arm ◽

Muscle Area ◽

Age And Gender ◽

Under Nutrition ◽

And Gender ◽

Mid Upper Arm Circumference ◽

The Relationship

Background: Globally, under-nutrition and hypertension in children has been associated with the risk of developing cardiovascular disease (CVD) in adulthood. The main objective of this study was to investigate the relationship between under-nutrition and hypertension, furthermore, to determine the risk of developing hypertension due to under-nutrition. Methods: The study comprised of 1701 participants (874 boys and 827 girls) between the ages of 9 and 17 years old. All anthropometric and blood pressure measurements were taken according to standard procedures. Mid-upper arm circumference (MUAC), body mass index (BMI), upper arm fat area (UFA), total upper arm area (TUAA) and upper arm muscle area (UMA) of Ellisras children were compared with the National Health and Nutrition Examination Survey III reference population. The linear regression models were used to determine the relationship between under-nutrition with hypertension for unadjusted and then adjusted for age and gender. The logistic regression model was used to determine the risk of under-nutrition on developing hypertension for unadjusted and adjusted for age and gender. Results: There was a positive significant (p < 0.0001) association between all under-nutrition variables (MUAC, BMI, UFA, TUAA and UMA) and systolic blood pressure (SBP; beta ranges between 0.84 and 2.78), and diastolic blood pressure (DBP; beta ranges between 0.3 and 1.08 before adjusting and after adjusting for age and gender (SBP, beta ranges between 0.59 and 2.00 and DBP (beta ranges between 0.24 and 0.80. Conclusion: The prevalence of under-nutrition was high while the prevalence of hypertension was low in this study. The mean under-nutrition variables (BMI, UFA, UMA and MUAC) of Ellisras children were far lower compared to the NHANES III reference population. Hypertension was significantly associated with under-nutrition in this study.

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