Blood Pressure and Immunoglobulins

1. Serum concentrations of IgG and IgM were measured in 87 hypertensive and 87 normotensive subjects, matched for age and gender, and selected from the same general population. 2. No significant differences between these two groups were found, in contrast to some previous reports. 3. The reasons for this discrepancy are discussed.

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Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

Genetics Research ◽

10.1017/s001667231200050x ◽

2012 ◽

Vol 94 (6) ◽

pp. 331-337 ◽

Cited By ~ 30

Author(s):

MARYAM ZARKESH ◽

MARYAM SADAT DANESHPOUR ◽

BITA FAAM ◽

MOHAMMAD SADEGH FALLAH ◽

NIMA HOSSEINZADEH ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Hdl Cholesterol ◽

Age And Gender ◽

The Metabolic Syndrome ◽

Biological Parents ◽

Heritability Estimation ◽

Low Hdl ◽

And Gender ◽

Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

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Associations between mental illnesses and acute cardiovascular events and cancers in France in 2016

European Journal of Public Health ◽

10.1093/eurpub/ckz187.194 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

T Lesuffleur ◽

M Coldefy ◽

A Rachas ◽

C Gastaldi-Ménager ◽

P Tuppin

Keyword(s):

Heart Failure ◽

Mental Illness ◽

Pulmonary Embolism ◽

General Population ◽

Cardiovascular Events ◽

Healthcare Professionals ◽

Mental Illnesses ◽

Age And Gender ◽

Addictive Disorder ◽

And Gender

Abstract Background People with a mental illness have higher risks of somatic diseases and higher mortality, but this has been poorly documented in France. We studied the associations between mental illnesses and acute cardiovascular events (ACEs) and cancers in the French national health data system (SNDS). Methods We included all health insurance general scheme beneficiaries ≥18 years-of-age in 2016. Mental illnesses (psychotic disorder, neurotic or mood disorder, mental retardation and addictive disorder), ACEs (acute coronary syndrome (ACS), stroke, acute heart failure and pulmonary embolism) and cancers (breast, colorectal, lung and prostate) were identified using algorithms based on long-term disease registry, hospitalization diagnoses and specific drug deliveries. The associations were measured using morbidity ratios standardized by age and gender when appropriate (SMRs). Results ACEs were more frequent in the subjects with a mental illness than in the general population: ACS (SMR: 1.6), stroke (2.3), acute heart failure (1.9), pulmonary embolism (2.4). Similar results were found for each mental illness, except for ACS, which were less frequent in those with a mental retardation (SMR: 0.5) and were not associated with psychotic disorder (SMR: 1.0). Mental illness was also associated with more frequent breast (SMR: 1.3), colorectal (1.3), lung (2.0) and prostate (1.2) cancers, in particular for those with a neurotic or mood disorder (SMRs: 1.3, 1.5, 2.3, 1.2, respectively) and, for lung cancer, those with an addictive disorder (SMR: 2.6). Conclusions Globally, ACEs and cancers were more frequent in patients with a mental illness relative to the general population after standardization by age and gender, which could be related to adverse effects of certain psychotropic drugs or behaviours or risk factors related to the mental illness. Healthcare professionals should be aware of this to more adequately account for the specificities of the patients with a mental illness. Key messages ACEs and cancers were more frequent in patients with a mental illness relative to the general population after standardization by age and gender. Healthcare professionals should be aware of this to more adequately account for the specificities of the patients with a mental illness.

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4.3 IMPACT OF AGE AND GENDER ON THE HAEMODYNAMIC DETERMINANTS OF BLOOD PRESSURE ACROSS THE ADULT AGE-SPAN

Artery Research ◽

10.1016/j.artres.2014.09.071 ◽

2014 ◽

Vol 8 (4) ◽

pp. 127

Author(s):

A. Cocks ◽

J. Smith ◽

J. Woodcock-Smith ◽

K. Miles ◽

K. Maki-Petaja ◽

...

Keyword(s):

Blood Pressure ◽

Age And Gender ◽

Adult Age ◽

And Gender

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Effects of age and gender on ambulatory blood pressure and heart rate

Journal of Human Hypertension ◽

10.1038/sj.jhh.1000592 ◽

1998 ◽

Vol 12 (4) ◽

pp. 253-257 ◽

Cited By ~ 15

Author(s):

F Jaquet ◽

IB Goldstein ◽

D Shapir

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Ambulatory Blood Pressure ◽

Age And Gender ◽

And Gender

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Epidemiology, morbidity and mortality in Behçet’s disease: a cohort study using The Health Improvement Network (THIN)

Rheumatology ◽

10.1093/rheumatology/keaa010 ◽

2020 ◽

Vol 59 (10) ◽

pp. 2785-2795 ◽

Cited By ~ 1

Author(s):

Tom Thomas ◽

Joht Singh Chandan ◽

Anuradhaa Subramanian ◽

Krishna Gokhale ◽

George Gkoutos ◽

...

Keyword(s):

Pulmonary Embolism ◽

Cohort Study ◽

Heart Disease ◽

General Population ◽

Venous Thrombosis ◽

Ischaemic Heart Disease ◽

Thromboembolic Disease ◽

Age And Gender ◽

Increased Risk ◽

And Gender

Abstract Objectives The epidemiology of Behçet’s disease (BD) has not been well characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic disease and mortality in patients with BD compared with the general population is scarce. Methods We used a large UK primary care database to investigate the epidemiology of BD. A retrospective matched cohort study was used to assess the following outcomes: risk of cardiovascular, thromboembolic disease and mortality. Controls were selected at a 1:4 ratio (age and gender matched). Cox proportional hazard models were used to derive adjusted hazard ratios (aHR). Results The prevalence of BD was 14.61 (95% CI 13.35–15.88) per 100 000 population in 2017. A total of 1281 patients with BD were compared with 5124 age- and gender-matched controls. There was significantly increased risk of ischaemic heart disease [aHR 3.09 (1.28–7.44)], venous thrombosis [aHR 4.80 (2.42–9.54)] and mortality [aHR 1.40 (1.07–1.84)] in patients with BD compared with corresponding controls. Patients with BD were at higher risk of pulmonary embolism compared with corresponding controls at baseline [adjusted odds ratio 4.64 (2.66–8.09), P < 0.0001]. The majority of patients with pulmonary embolism and a diagnosis of BD had pulmonary embolism preceding the diagnosis of BD, not after (87.5%; n = 28/32). Conclusion BD has a higher prevalence than previously thought. Physicians should be aware of the increased risk of developing ischaemic heart disease, stroke/transient ischaemic attack and deep venous thrombosis in patients with BD at an earlier age compared with the general population. Risk of embolism in patients with BD might vary across the disease course.

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F96. AGE AND GENDER DETERMINED DIFFERENCES IN THE ONSET OF CHRONIC PHYSICAL MULTIMORBIDITIES AMONG PATIENTS WITH SCHIZOPHRENIA OR DEPRESSION AND THE GENERAL POPULATION

Schizophrenia Bulletin ◽

10.1093/schbul/sby017.627 ◽

2018 ◽

Vol 44 (suppl_1) ◽

pp. S257-S257

Author(s):

Ivona Šimunović Filipčić ◽

Ena Ivezić ◽

Željko Milovac ◽

Ines Kašpar ◽

Sandra Kocijan Lovko ◽

...

Keyword(s):

General Population ◽

Age And Gender ◽

And Gender

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Use of driving-impairing medicines by a Spanish population: a population-based registry study

BMJ Open ◽

10.1136/bmjopen-2017-017618 ◽

2017 ◽

Vol 7 (11) ◽

pp. e017618 ◽

Cited By ~ 10

Author(s):

Eduardo Gutierrez-Abejón ◽

Francisco Herrera-Gómez ◽

Paloma Criado-Espegel ◽

F Javier Alvarez

Keyword(s):

General Population ◽

Census Data ◽

Population Based ◽

Spanish Population ◽

Registry Study ◽

Age And Gender ◽

Patterns Of Use ◽

And Gender ◽

Population Based Registry ◽

Chronic Use

ObjectiveTo assess the use of driving-impairing medicines (DIM) in the general population with special reference to length of use and concomitant use.DesignPopulation-based registry study.SettingThe year 2015 granted medicines consumption data recorded in the Castile and León (Spain) medicine dispensation registry was consulted.ParticipantsMedicines and DIM consumers from a Spanish population (Castile and León: 2.4 million inhabitants).ExposureMedicines and DIM consumption. Patterns of use by age and gender based on the length of use (acute: 1–7 days, subacute: 8–29 days and chronic use: ≥30 days) were of interest. Estimations regarding the distribution of licensed drivers by age and gender were employed to determine the patterns of use of DIM.ResultsDIM were consumed by 34.4% (95% CI 34.3% to 34.5%) of the general population in 2015, more commonly with regularity (chronic use: 22.5% vs acute use: 5.3%) and more frequently by the elderly. On average, 2.3 DIM per person were dispensed, particularly to chronic users (2.8 DIM per person). Age and gender distribution differences were observed between the Castile and León medicine dispensation registry data and the drivers’ license census data. Of all DIM dispensed, 83.8% were in the Anatomical Therapeutic Chemical code group nervous system medicines (N), which were prescribed to 29.2% of the population.ConclusionsThe use of DIM was frequent in the general population. Chronic use was common, but acute and subacute use should also be considered. This finding highlights the need to make patients, health professionals, health providers, medicine regulatory agencies and policy-makers at large aware of the role DIM play in traffic safety.

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