scholarly journals Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Lei Xu ◽  
Yuxi Wu ◽  
Zhimiao Xiong ◽  
Yan Zhou ◽  
Zhaoyang Ye ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Chondrocytes ◽  
Paracrine Secretion

scholarly journals Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles

2009 ◽  
Vol 27 (4) ◽  
pp. 435-441 ◽  
Author(s):  
Yuko Segawa ◽  
Takeshi Muneta ◽  
Hatsune Makino ◽  
Akimoto Nimura ◽  
Tomoyuki Mochizuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Anterior Cruciate Ligament ◽  
Articular Chondrocytes ◽  
Expression Profiles ◽  
Cruciate Ligament ◽  
Gene Expression Profiles ◽  
Anterior Cruciate ◽  
Similar Gene

scholarly journals Chondrogenesis of cocultures of mesenchymal stem cells and articular chondrocytes in poly(l-lysine)-loaded hydrogels

2020 ◽  
Vol 328 ◽  
pp. 710-721
Author(s):  
Yu Seon Kim ◽  
Athena J. Chien ◽  
Jason L. Guo ◽  
Brandon T. Smith ◽  
Emma Watson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Chondrocytes

scholarly journals Epigenetic modifying compounds alter activity of primary human articular chondrocytes and mesenchymal stem cells undergoing chondrogenesis

2014 ◽  
Vol 22 ◽  
pp. S141
Author(s):  
S. Snelling ◽  
A. Kramm ◽  
C. Yapp ◽  
A. Carr ◽  
U. Oppermann
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Chondrocytes ◽  
Human Articular Chondrocytes

scholarly journals Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model

Biomaterials ◽  
2014 ◽  
Vol 35 (26) ◽  
pp. 7460-7469 ◽  
Author(s):  
Rebecca L. Dahlin ◽  
Lucas A. Kinard ◽  
Johnny Lam ◽  
Clark J. Needham ◽  
Steven Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteochondral Defect ◽  
Articular Chondrocytes ◽  
Defect Model ◽  
Biodegradable Scaffolds

scholarly journals Co-cultivated mesenchymal stem cells support chondrocytic differentiation of articular chondrocytes

2013 ◽  
Vol 37 (4) ◽  
pp. 747-752 ◽  
Author(s):  
Qiang Zuo ◽  
Weiding Cui ◽  
Feng Liu ◽  
Qing Wang ◽  
Zhefeng Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Chondrocytes ◽  
Chondrocytic Differentiation

scholarly journals Engineered Mesenchymal Stem Cells with Enhanced Tropism and Paracrine Secretion of Cytokines and Growth Factors to Treat Traumatic Brain Injury

Stem Cells ◽  
2015 ◽  
Vol 33 (2) ◽  
pp. 456-467 ◽  
Author(s):  
Zhe Wang ◽  
Yu Wang ◽  
Zhiyong Wang ◽  
J. Silvio Gutkind ◽  
Zhongliang Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Brain Injury ◽  
Paracrine Secretion

Elucidating the Pivotal Role of Immune Players in the Management of COVID-19: Focus on Mesenchymal Stem Cells and Inflammation

2020 ◽  
Vol 15 ◽  
Author(s):  
Seidu A. Richard ◽  
Sylvanus Kampo ◽  
Marian Sackey ◽  
Maite Esquijarosa Hechavarria ◽  
Alexis D. B. Buunaaim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Disease Burden ◽  
Viral Disease ◽  
Inflammatory Factors ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Paracrine Secretion ◽  
Polymerase Chain

: The world is currently engulfed with a viral disease with no cure. So, far, millions of people are infected with the virus across the length and breadth of world with thousand losing their lives each passing day. The WHO is February 2020 classified the virus as a coronavirus and the name Coronavirus-19 (CoV-19) was offered to the virus. The disease caused by the virus was termed coronavirus disease-19 (COVID-19). The pathogenesis of COVID-19 is associated with elevation of several immune plays as well as inflammatory factors which contributes to cytokine storms. Currently, the detection of CoV-19 RNA is through reverse transcriptase polymerase chain reaction (RT-PCR). Mesenchymal stem cells (MSCs) are capable of suppressing several kinds of cytokines via the paracrine secretion system. Therefore, MSCs therapy could be game charges in the treatment of the current COVID-19 pandemic. Also, intravenous IG may be capable of suppressing the high expression of IL-6 by the CoV-19 resulting in lessen disease burden. Anti-inflammatory medications like, corticosteroids, tocilizumab, glycyrrhetinic acid, as well as etoposide may be very advantageous in decreasing the COVID-19 burden because, their mode of action targets the cytokine storms initiated by the CoV-19. It is important to indicate that, these medication does not target the virus itself. Therefore, potent CoV-19 anti-viral medications are needed to completely cure patients with COVID-19. Also, a vaccine is urgently needed to stop the spread of the virus. This review therefore elucidates the immune players in the management of COVID-19; focusing principally on MSCs and inflammatory mediators.

Sign in / Sign up

Export Citation Format

Share Document