scholarly journals Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qihua Yang ◽  
Tao Huang ◽  
Guoliang Ye ◽  
Bojun Wang ◽  
Xinjun Zhang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Noninvasive Biomarker

scholarly journals The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200735 ◽  
Author(s):  
Afsaneh Mojtabanezhad Shariatpanahi ◽  
Maryam Yassi ◽  
Mehdi Nouraie ◽  
Amirhossein Sahebkar ◽  
Fatemeh Varshoee Tabrizi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Stool Dna

MicroRNA-21 as a Potential Biomarker for Colorectal Cancer Diagnosis: A Meta-analysis

2016 ◽  
Vol 17 (8) ◽  
pp. 1-13
Author(s):  
Chao-Hui Zhen ◽  
Guo-Jun Yao ◽  
Yan Tan ◽  
Lu Yang ◽  
Xiao-Fang Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Potential Biomarker

The value of microRNAs as the novel biomarkers for colorectal cancer diagnosis: A meta-analysis

2020 ◽  
Vol 216 (10) ◽  
pp. 153130
Author(s):  
Zhihua Zuo ◽  
Yao Jiang ◽  
Shanshui Zeng ◽  
Yiqin Li ◽  
Jia Fan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
The Novel ◽  
Novel Biomarkers

scholarly journals CK20 mRNA expression in serum as a biomarker for colorectal cancer diagnosis: A meta-analysis

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 347-353
Author(s):  
Baoyan Ji ◽  
Xiongfei Cheng ◽  
Xiaojun Cai ◽  
Chuiyan Kong ◽  
Qingyan Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Sensitivity And Specificity ◽  
Cancer Diagnosis ◽  
Roc Curve ◽  
Meta Analysis ◽  
Random Effect ◽  
Diagnostic Sensitivity ◽  
Diagnostic Sensitivity And Specificity ◽  
Effect Method

AbstractThe aim of this study was to evaluate the diagnostic value of serumCK20 mRNA as a biomarker for colorectal cancer diagnosis by meta-analysis.Clinical studies related to serum CK20 mRNA expression for colorectal cancer diagnosis were searched in the databases of Pubmed, Cochrane Library, Embase, ISI Web of Knowledge, CNKI and Wanfang. The number of true positive (tp), false positive (fp), false negative (fn) and true negative (tn) of the original included publications were extracted by two reviewers independently. The diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likelyhood ratio (-LR), diagnostic odds ratio (DOR) and area under the symmetric ROC curve (AUC) were pooled by random or fixed effect method according to the statistical heterogeneity among the studies.After screening the databases, nineteen publications met the inclusion criteria and were finally included in this meta-analysis. The diagnostic sensitivity and specificity were pooled by random effect model(I2>50%). The pooled diagnostic sensitivity and specificity of CK20 mRNA in serum as biomarker for colorectal cancer were 0.49 (95% CI:0.46 to 0.51) and 0.94 (95%CI:0.92-0.96) respectively. The pooled +LR and −LR were 10.90 (95%CI:5.78 to 20.55) and 0.51 (95%CI:0.45 to 0.57) respectively by random-effect method. The pooled DOR was 22.31 with the 95% CI of 11.65 to 42.71. The pooled area under the ROC curve (AUC) was 0.72for CK20 mRNA in serum as a biomarker for colorectal cancer diagnosis. Conclusion Serum CK20 mRNA expression was significantly elevated in colorectal cancer patients which could be a promising serum biomarker for colorectal cancer diagnosis with high specificity.

Distinct trajectories of positive and negative affect after colorectal cancer diagnosis.

2017 ◽  
Vol 36 (6) ◽  
pp. 521-528 ◽  
Author(s):  
Yvette Ciere ◽  
Moniek Janse ◽  
Josué Almansa ◽  
Annemieke Visser ◽  
Robbert Sanderman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Negative Affect ◽  
Cancer Diagnosis ◽  
Positive And Negative Affect

Epigenetic Modifiers and Their Potential Application in Colorectal Cancer Diagnosis and Therapy

2020 ◽  
Vol 25 (2) ◽  
pp. 95-109
Author(s):  
Sapnita Shinde ◽  
Saurabh Saxena ◽  
Vineeta Dixit ◽  
Atul K. Tiwari ◽  
Naveen K. Vishvakarma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Potential Application ◽  
Diagnosis And Therapy ◽  
Epigenetic Modifiers ◽  
Cancer Diagnosis And Therapy

The role of serum periostin in the diagnosis of asthma: A meta-analysis

2020 ◽  
Vol 41 (4) ◽  
pp. 240-247
Author(s):  
Lei Yang ◽  
Qingtao Zhao ◽  
Shuyu Wang
Keyword(s):  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
False Negative ◽  
Summary Receiver Operating Characteristic ◽  
True Negative ◽  
Negative Results ◽  
Noninvasive Biomarker ◽  
Sensitivity Specificity ◽  
Serum Periostin

Background: Serum periostin has been proposed as a noninvasive biomarker for asthma diagnosis and management. However, its accuracy for the diagnosis of asthma in different populations is not completely clear. Methods: This meta-analysis aimed to evaluate the diagnostic accuracy of periostin level in the clinical determination of asthma. Several medical literature data bases were searched for relevant studies through December 1, 2019. The numbers of patients with true-positive, false-positive, false-negative, and true-negative results for the periostin level were extracted from each individual study. We assessed the risk of bias by using Quality Assessment of Diagnostic Accuracy Studies 2. We used the meta-analysis to produce summary estimates of accuracy. Results: In total, nine studies with 1757 subjects met the inclusion criteria. The pooled estimates of sensitivity, specificity, and diagnostic odds ratios for the detection of asthma were 0.58 (95% confidence interval [CI], 0.38‐0.76), 0.86 (95% CI, 0.74‐0.93), and 8.28 (95% CI, 3.67‐18.68), respectively. The area under the summary receiver operating characteristic curve was 0.82 (95% CI, 0.79‐0.85). And significant publication bias was found in this meta‐analysis (p = 0.39). Conclusion: Serum periostin may be used for the diagnosis of asthma, with moderate diagnostic accuracy.

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