scholarly journals Erratum: Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Physico Chemical ◽  
Differential Toxicity ◽  
Reduced Graphene

scholarly journals Author Correction: Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Physico Chemical ◽  
Differential Toxicity ◽  
Reduced Graphene

scholarly journals Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Epithelial Cells ◽  
Biomedical Applications ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Lateral Size ◽  
Human Lung Cells ◽  
Physico Chemical

Abstract Graphene derivatives (GD) are currently being evaluated for technological and biomedical applications owing to their unique physico-chemical properties over other carbon allotrope such as carbon nanotubes (CNTs). But, the possible association of their properties with underlying in vitro effects have not fully examined. Here, we assessed the comparative interaction of three GD - graphene oxide (GO), thermally reduced GO (TRGO) and chemically reduced GO (CRGO), which significantly differ in their lateral size and functional groups density, with phenotypically different human lung cells; bronchial epithelial cells (BEAS-2B) and alveolar epithelial cells (A549). The cellular studies demonstrate that GD significantly ineternalize and induce oxidative stress mediated cytotoxicity in both cells. The toxicity intensity was in line with the reduced lateral size and increased functional groups revealed more toxicity potential of TRGO and GO respectively. Further, A549 cells showed more susceptibility than BEAS-2B which reflected cell type dependent differential cellular response. Molecular studies revealed that GD induced differential cell death mechanism which was efficiently prevented by their respective inhibitors. This is prior study to the best of our knowledge involving TRGO for its safety evaluation which provided invaluable information and new opportunities for GD based biomedical applications.

scholarly journals Tuning Properties of Partially Reduced Graphene Oxide Fibers upon Calcium Doping

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 957 ◽  
Author(s):  
Krzysztof Tadyszak ◽  
Jacek K. Wychowaniec ◽  
Karol Załęski ◽  
Emerson Coy ◽  
Łukasz Majchrzycki ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Chemical Properties ◽  
Fiber Axis ◽  
Paramagnetic Resonance ◽  
Physico Chemical ◽  
Reduced Graphene ◽  
Calcium Doping ◽  
Bulk Structures ◽  
Pulsed Electron Paramagnetic Resonance ◽  
Electron Paramagnetic

The arrangement of two-dimensional graphene oxide sheets has been shown to influence physico-chemical properties of the final bulk structures. In particular, various graphene oxide microfibers remain of high interest in electronic applications due to their wire-like thin shapes and the ease of hydrothermal fabrication. In this research, we induced the internal ordering of graphene oxide flakes during typical hydrothermal fabrication via doping with Calcium ions (~6 wt.%) from the capillaries. The Ca2+ ions allowed for better graphene oxide flake connections formation during the hydrogelation and further modified the magnetic and electric properties of structures compared to previously studied aerogels. Moreover, we observed the unique pseudo-porous fiber structure and flakes connections perpendicular to the long fiber axis. Pulsed electron paramagnetic resonance (EPR) and conductivity measurements confirmed the denser flake ordering compared to previously studied aerogels. These studies ultimately suggest that doping graphene oxide with Ca2+ (or other) ions during hydrothermal methods could be used to better control the internal architecture and thus tune the properties of the formed structures.

Oxidative Stress Induces Arachidonate Release from Human Lung Cells through the Epithelial Growth Factor Receptor Pathway

2002 ◽  
Vol 27 (6) ◽  
pp. 722-731 ◽  
Author(s):  
Rafal Pawliczak ◽  
Xiu-Li Huang ◽  
Uday B. Nanavaty ◽  
Marion Lawrence ◽  
Patricia Madara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Human Lung ◽  
Growth Factor Receptor ◽  
Epithelial Growth Factor Receptor ◽  
Lung Cells ◽  
Epithelial Growth Factor ◽  
Human Lung Cells ◽  
Arachidonate Release ◽  
Epithelial Growth

Alleviating effects of reduced graphene oxide against lead‐induced cytotoxicity and oxidative stress in human alveolar epithelial (A549) cells

2020 ◽  
Vol 40 (9) ◽  
pp. 1228-1238 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M.A. Majeed Khan ◽  
Hisham A. Alhadlaq
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
A549 Cells ◽  
Alveolar Epithelial ◽  
Reduced Graphene ◽  
And Oxidative Stress

Graphene oxide is degraded by neutrophils and the degradation products are non-genotoxic

Nanoscale ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 1180-1188 ◽  
Author(s):  
Sourav P. Mukherjee ◽  
Anda R. Gliga ◽  
Beatrice Lazzaretto ◽  
Birgit Brandner ◽  
Matthew Fielden ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Human Lung ◽  
Degradation Products ◽  
Lung Cells ◽  
Human Lung Cells

Graphene oxide (GO) undergoes neutrophil myeloperoxidase (MPO) dependent degradation and the degradation products are non-genotoxic for human lung cells.

scholarly journals Nanosized Zinc Oxide Induces Toxicity in Human Lung Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Devashri Sahu ◽  
G. M. Kannan ◽  
R. Vijayaraghavan ◽  
T. Anand ◽  
Farhath Khanum
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Cell Viability ◽  
Human Lung ◽  
Lung Cells ◽  
Dependent Manner ◽  
Zno Nps ◽  
Oxidative Stress Parameters ◽  
Human Lung Cells ◽  
Stress Parameters

Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. This study investigates the toxic effects of ZnO-NPs in human lung cells. In order to assess toxicity, human lung epithelial cells (L-132) were exposed to dispersion of 50 nm ZnO-NPs at concentrations of 5, 25, 50, and 100 μg/mL for 24 h. The toxicity was evaluated by observing changes in cell morphology, cell viability, oxidative stress parameters, DNA damage analysis, and gene expression. Exposure to 50 nm ZnO-NPs at concentrations between 5 and 100 μg/mL decreased cell viability in a concentration-dependent manner. Morphological examination revealed cell shrinkage, nuclear condensation, and formation of apoptotic bodies. The oxidative stress parameters revealed significant depletion of GSH level and increase in ROS levels suggesting generation of oxidative stress. ZnO-NPs exposure caused DNA fragmentation demonstrating apoptotic type of cell death. ZnO-NPs increased the expression of metallothionein gene, which is considered as a biomarker in metal-induced toxicity. To summarize, ZnO-NPs cause toxicity in human lung cells possibly through oxidative stress-induced apoptosis.

Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells

2018 ◽  
Vol 233 (8) ◽  
pp. 6018-6027 ◽  
Author(s):  
Rita Canella ◽  
Mascia Benedusi ◽  
Marta Martini ◽  
Franco Cervellati ◽  
Carlotta Cavicchio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Chloride Current ◽  
Lung Cells ◽  
Human Lung Cells

scholarly journals Next‐Generation Sequencing Reveals Differential Responses to Acute versus Long‐Term Exposures to Graphene Oxide in Human Lung Cells

Small ◽  
2020 ◽  
Vol 16 (21) ◽  
pp. 1907686 ◽  
Author(s):  
Sourav P. Mukherjee ◽  
Govind Gupta ◽  
Katharina Klöditz ◽  
Jun Wang ◽  
Artur Filipe Rodrigues ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Next Generation Sequencing ◽  
Human Lung ◽  
Lung Cells ◽  
Next Generation ◽  
Human Lung Cells ◽  
Differential Responses ◽  
Generation Sequencing
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