Alleviating effects of reduced graphene oxide against lead‐induced cytotoxicity and oxidative stress in human alveolar epithelial (A549) cells

2020 ◽  
Vol 40 (9) ◽  
pp. 1228-1238 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M.A. Majeed Khan ◽  
Hisham A. Alhadlaq

ACS Nano ◽  
2011 ◽  
Vol 5 (9) ◽  
pp. 6971-6980 ◽  
Author(s):  
Shaobin Liu ◽  
Tingying Helen Zeng ◽  
Mario Hofmann ◽  
Ehdi Burcombe ◽  
Jun Wei ◽  
...  


2020 ◽  
Vol 143 ◽  
pp. 111515 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M.A. Majeed Khan ◽  
Hisham A. Alhadlaq


2018 ◽  
Vol 6 (11) ◽  
pp. 209-209 ◽  
Author(s):  
Jin Li ◽  
Qiulian Zhou ◽  
Yajun Liang ◽  
Wen Pan ◽  
Yihua Bei ◽  
...  




2021 ◽  
Vol 22 (22) ◽  
pp. 12593
Author(s):  
Rafał Krętowski ◽  
Agata Jabłońska-Trypuć ◽  
Marzanna Cechowska-Pasko

Breast cancer is the most common cancer diagnosed in women, however traditional therapies have several side effects. This has led to an urgent need to explore novel drug approaches to treatment strategies such as graphene-based nanomaterials such as reduced graphene oxide (rGO). It was noticed as a potential drug due to its target selectivity, easy functionalisation, chemisensitisation, and high drug-loading capacity. rGO is widely used in many fields, including biological and biomedical, due to its unique physicochemical properties. However, the possible mechanisms of rGO toxicity remain unclear. In this paper, we present findings on the cytotoxic and antiproliferative effects of rGO and its ability to induce oxidative stress and apoptosis of breast cancer cell lines. We indicate that rGO induced time- and dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cell lines, but not in T-47D, MCF-7, Hs 578T cell lines. In rGO-treated MDA-MB-231 and ZR-75-1 cell lines, we noticed increased induction of apoptosis and necrosis. In addition, rGO has been found to cause oxidative stress, reduce proliferation, and induce structural changes in breast cancer cells. Taken together, these studies provide new insight into the mechanism of oxidative stress and apoptosis in breast cancer cells.



2015 ◽  
Vol 25 (3) ◽  
pp. 212-222 ◽  
Author(s):  
Ting-Ting Zhang ◽  
Ge Zhao ◽  
Xiang Li ◽  
Fu-Wei Xie ◽  
Hui-Min Liu ◽  
...  




2018 ◽  
Vol 272 ◽  
pp. 274-281 ◽  
Author(s):  
Mani Govindasamy ◽  
Shaktivel Manavalan ◽  
Shen-Ming Chen ◽  
Rajaji Umamaheswari ◽  
Tse-Wei Chen


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