Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells

2018 ◽  
Vol 233 (8) ◽  
pp. 6018-6027 ◽  
Author(s):  
Rita Canella ◽  
Mascia Benedusi ◽  
Marta Martini ◽  
Franco Cervellati ◽  
Carlotta Cavicchio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Chloride Current ◽  
Lung Cells ◽  
Human Lung Cells

Effect of ozone oxidative stress on chloride current in human lung cells: Chemical mediators and protective role of catalase

2017 ◽  
Vol 108 ◽  
pp. S45
Author(s):  
Rita Canella ◽  
Mascia Benedusi ◽  
Carlotta Cavicchio ◽  
Franco Cervellati ◽  
Marta Martini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Protective Role ◽  
Chloride Current ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Chemical Mediators

Oxidative Stress Induces Arachidonate Release from Human Lung Cells through the Epithelial Growth Factor Receptor Pathway

2002 ◽  
Vol 27 (6) ◽  
pp. 722-731 ◽  
Author(s):  
Rafal Pawliczak ◽  
Xiu-Li Huang ◽  
Uday B. Nanavaty ◽  
Marion Lawrence ◽  
Patricia Madara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Human Lung ◽  
Growth Factor Receptor ◽  
Epithelial Growth Factor Receptor ◽  
Lung Cells ◽  
Epithelial Growth Factor ◽  
Human Lung Cells ◽  
Arachidonate Release ◽  
Epithelial Growth

scholarly journals Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62968 ◽  
Author(s):  
Irina Petrache ◽  
Krzysztof Kamocki ◽  
Christophe Poirier ◽  
Yael Pewzner-Jung ◽  
Elad L. Laviad ◽  
...  
Keyword(s):  
Mouse Models ◽  
Human Lung ◽  
Lung Cells ◽  
Ceramide Synthase ◽  
Human Lung Cells ◽  
Ceramide Synthases

scholarly journals Nanosized Zinc Oxide Induces Toxicity in Human Lung Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Devashri Sahu ◽  
G. M. Kannan ◽  
R. Vijayaraghavan ◽  
T. Anand ◽  
Farhath Khanum
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Cell Viability ◽  
Human Lung ◽  
Lung Cells ◽  
Dependent Manner ◽  
Zno Nps ◽  
Oxidative Stress Parameters ◽  
Human Lung Cells ◽  
Stress Parameters

Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. This study investigates the toxic effects of ZnO-NPs in human lung cells. In order to assess toxicity, human lung epithelial cells (L-132) were exposed to dispersion of 50 nm ZnO-NPs at concentrations of 5, 25, 50, and 100 μg/mL for 24 h. The toxicity was evaluated by observing changes in cell morphology, cell viability, oxidative stress parameters, DNA damage analysis, and gene expression. Exposure to 50 nm ZnO-NPs at concentrations between 5 and 100 μg/mL decreased cell viability in a concentration-dependent manner. Morphological examination revealed cell shrinkage, nuclear condensation, and formation of apoptotic bodies. The oxidative stress parameters revealed significant depletion of GSH level and increase in ROS levels suggesting generation of oxidative stress. ZnO-NPs exposure caused DNA fragmentation demonstrating apoptotic type of cell death. ZnO-NPs increased the expression of metallothionein gene, which is considered as a biomarker in metal-induced toxicity. To summarize, ZnO-NPs cause toxicity in human lung cells possibly through oxidative stress-induced apoptosis.

scholarly journals Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

2009 ◽  
Vol 6 (1) ◽  
pp. 17 ◽  
Author(s):  
Kunal Bhattacharya ◽  
Maria Davoren ◽  
Jens Boertz ◽  
Roel PF Schins ◽  
Eik Hoffmann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Human Lung ◽  
Titanium Dioxide Nanoparticles ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Lung Cells ◽  
Dna Breakage ◽  
Human Lung Cells

scholarly journals Author Correction: Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Physico Chemical ◽  
Differential Toxicity ◽  
Reduced Graphene

scholarly journals Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB

2015 ◽  
Vol 39 (2) ◽  
pp. 845-856 ◽  
Author(s):  
Rosa I. Rodríguez-Cotto ◽  
Mario G. Ortiz-Martínez ◽  
Braulio D. Jiménez-Vélez
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Inflammatory Responses ◽  
Dust Storms ◽  
Lung Cells ◽  
African Dust ◽  
Human Lung Cells ◽  
Organic Extracts

Silica nanoparticle induces oxidative stress and provokes inflammation in human lung cells

2014 ◽  
Vol 10 (13) ◽  
pp. 983-1000 ◽  
Author(s):  
Devashri Sahu ◽  
R. Vijayaraghavan ◽  
G.M. Kannan
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Silica Nanoparticle ◽  
Lung Cells ◽  
Human Lung Cells
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