scholarly journals Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Seong Beom Cho ◽  
InSong Koh ◽  
Hye-Young Nam ◽  
Jae-Pil Jeon ◽  
Hong Kyu Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Glucose Tolerance ◽  
Copy Number ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Oral Glucose Tolerance Testing ◽  
Mitochondrial Dna Copy Number ◽  
Tolerance Testing

scholarly journals Carbohydrate Intake Prior to Oral Glucose Tolerance Testing

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Klara R Klein ◽  
Christopher P Walker ◽  
Amber L McFerren ◽  
Halie Huffman ◽  
Flavio Frohlich ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Research Participant ◽  
Carbohydrate Intake ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Oral Glucose Tolerance Testing ◽  
Glucose Levels

Abstract With the emergence of glycated hemoglobin as a diagnostic test for diabetes, oral glucose tolerance tests (OGTTs) have become rare in endocrinology practice. As they have moved out of favor, the importance of patient instructions on preparation prior to OGTT has faded from memory. Decades-old literature, well-known to endocrinologists a generation ago, emphasized the importance of carbohydrate intake prior to OGTT. In this expert endocrine consult, we discuss an OGTT performed in a research setting without adequate carbohydrate intake at the evening meal prior to the OGTT. The resultant elevated plasma glucose levels at 1-hour and 2-hours mimicked the loss of first-phase insulin release seen in early type 1 and type 2 diabetes. With clinical concern that the research participant had evolving type 1 or type 2 diabetes, the volunteer was subjected to additional testing and experienced anxiety. Repeat OGTT was normal after adequate carbohydrate intake (>150 grams/day and >50 grams the evening prior to overnight fast for the study). The physiology of this phenomenon is explored and is likely mediated through beta cell adaptation and alteration in peripheral glucose uptake in response to nutrient exposure. The learnings of decades ago have clearly faded, and this literature should be revisited to ensure that OGTT results are not compromised when ordered for clinical or research purposes.

Trajectories of oral glucose tolerance testing in cystic fibrosis

2020 ◽  
Author(s):  
Monal Patel ◽  
Courtney McCracken ◽  
Tanicia Daley ◽  
Arlene Stecenko ◽  
Rachel Linnemann
Keyword(s):  
Cystic Fibrosis ◽  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Oral Glucose Tolerance Testing ◽  
Tolerance Testing
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