scholarly journals Mitochondrial DNA copy number associates with insulin sensitivity and aerobic capacity, and differs between sedentary, overweight middle-aged males with and without type 2 diabetes

2019 ◽  
Vol 44 (4) ◽  
pp. 929-936 ◽  
Author(s):  
Dumitru Constantin-Teodosiu ◽  
Despina Constantin ◽  
Maurice M. Pelsers ◽  
Lex B. Verdijk ◽  
Luc van Loon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Insulin Sensitivity ◽  
Aerobic Capacity ◽  
Copy Number ◽  
Middle Aged ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ashfaque A. Memon ◽  
Jan Sundquist ◽  
Anna Hedelius ◽  
Karolina Palmér ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Smoking Status ◽  
Population Based ◽  
Dna Copy Number ◽  
Follow Up Study ◽  
Mitochondrial Dna Copy Number

AbstractMitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50–59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.

scholarly journals Mitochondrial DNA Copy Number in Peripheral Blood Is Reduced in Type 2 Diabetes Patients with Polyneuropathy and Associated with a MIR499A Gene Polymorphism

2020 ◽  
Vol 39 (8) ◽  
pp. 1467-1472 ◽  
Author(s):  
Andrea Latini ◽  
Paola Borgiani ◽  
Giada De Benedittis ◽  
Cinzia D'Amato ◽  
Carla Greco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Gene Polymorphism ◽  
Peripheral Blood ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number ◽  
Diabetes Patients

scholarly journals Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

2021 ◽  
Author(s):  
F. Fazzini ◽  
C. Lamina ◽  
A. Raftopoulou ◽  
A. Koller ◽  
C. Fuchsberger ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Plasma lactate and leukocyte mitochondrial DNA copy number as biomarkers of insulin sensitivity in non-diabetic women

2019 ◽  
Vol 75 (3) ◽  
pp. 285-297
Author(s):  
José L. Santos ◽  
Luis R. Cataldo ◽  
Cristián Cortés-Rivera ◽  
Carolina Bravo ◽  
Luis Díaz-Casanova ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Insulin Sensitivity ◽  
Copy Number ◽  
Plasma Lactate ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Seong Beom Cho ◽  
InSong Koh ◽  
Hye-Young Nam ◽  
Jae-Pil Jeon ◽  
Hong Kyu Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Glucose Tolerance ◽  
Copy Number ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Oral Glucose Tolerance Testing ◽  
Mitochondrial Dna Copy Number ◽  
Tolerance Testing

scholarly journals Mitochondrial DNA copy number, metabolic syndrome, and insulin sensitivity: Insights from the Sugar, Hypertension, and Physical Exercise Studies

2021 ◽  
Author(s):  
Stephanie Yang ◽  
Caleb S Mirabal ◽  
Charles E Newcomb ◽  
Kerry J Stewart ◽  
Dan Arking
Keyword(s):  
Metabolic Syndrome ◽  
Mitochondrial Dna ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Physical Exercise ◽  
Copy Number ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Mitochondrial DNA copy number (mtDNA-CN) measured in blood has been associated with many aging-related diseases, with higher mtDNA-CN typically associated with lower disease risk. Exercise training is an excellent preventative tool against aging-related disorders and has been shown to increase mitochondrial function in muscle. Using the Sugar, Hypertension, and Physical Exercise cohorts (N = 105), we evaluated the effect of 6-months of exercise intervention on mtDNA-CN measured in blood. Although there was no significant relationship between exercise intervention and mtDNA-CN change (P = 0.29), there was a nominally significant association between mtDNA-CN and metabolic syndrome (P = 0.04), which has been seen in previous literature. We also identified a nominally significant association between higher mtDNA-CN and higher insulin sensitivity (P = 0.02).

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