scholarly journals Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents

2014 ◽  
Vol 14 (6) ◽  
pp. 493-502 ◽  
Author(s):  
H F Burnett ◽  
R Tanoshima ◽  
W Chandranipapongse ◽  
P Madadi ◽  
S Ito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thiopurine Methyltransferase ◽  
Clinical Guidance ◽  
Guidance Documents

scholarly journals Systematic review of clinical guidance documents for autism spectrum disorder diagnostic assessment in select regions

Autism ◽  
2017 ◽  
Vol 22 (5) ◽  
pp. 517-527 ◽  
Author(s):  
Melanie Penner ◽  
Evdokia Anagnostou ◽  
Lana Y Andoni ◽  
Wendy J Ungar
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Standard Deviation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Diagnostic Assessment ◽  
Assessment Practices ◽  
High Quality ◽  
Clinical Guidance ◽  
Guidance Documents

Clinical guidance documents play an important role in ensuring access to high-quality autism spectrum disorder diagnostic assessment practices. The objective was to perform a systematic review of professional association and government clinical guidance documents for autism spectrum disorder diagnostic assessment, analyzing their quality and content. The government search was limited to English-speaking, single-payer, publicly funded health systems. A quality appraisal was conducted by two appraisers using the Appraisal of Guidelines Research and Evaluation, second edition tool. A content analysis was conducted for recommended clinical personnel and psychometric tools. The 11 documents demonstrated higher quality in Scope and Purpose (mean: 90.1, standard deviation: 7.4) and Clarity of Presentation (mean: 82.8, standard deviation: 9.4) and lower quality in Applicability (mean: 43.3, standard deviation: 23.8) and Rigor of Development (mean: 52, standard deviation: 21.9). All documents either recommended multidisciplinary team assessment or stated it was ideal. The documents varied substantially in their recommended tools and personnel for diagnostic assessment. There was little supporting evidence for team and personnel recommendations. Multiple guidance documents exist for autism spectrum disorder diagnostic assessments, with varying quality and recommendations. The substantial variation likely stems from insufficient evidence supporting assessment practices. Research is required to close the evidence gaps and inform high-quality clinical guidelines.

Thromboprophylaxis in Patients with COVID-19: Systematic Review of National and International Clinical Guidance Reports

2021 ◽  
Vol 19 ◽  
Author(s):  
Konstantinos G Kyriakoulis ◽  
Anastasios Kollias ◽  
Ioannis G Kyriakoulis ◽  
Ioanna A Kyprianou ◽  
Chrysso Papachrysostomou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Intensity ◽  
Treatment Decision ◽  
Bleeding Risk ◽  
Post Discharge ◽  
Risk Patients ◽  
Guidance Documents ◽  
Current Guidance ◽  
High Bleeding Risk ◽  
Pharmacological Thromboprophylaxis

Background: Venous thromboembolism (VTE) is common among patients with severe coronavirus disease 2019 (COVID-19). Anticoagulation in hospitalized COVID-19 patients has been associated with survival benefit; however, the optimal thromboprophylaxis strategy has not yet been defined. Objective: To identify published guidance reports by national and international societies regarding thromboprophylaxis strategies in COVID-19 patients in different settings (outpatients, hospitalized, post-discharge). Methods: A systematic review of the literature (Pubmed/EMBASE) was conducted independently by two investigators. Results: Among 1942 initially identified articles, 33 guidance documents were included: 20 published by national and 13 by international societies. These documents provide recommendations mainly for hospitalized (97% of reports) and post-discharge (75%) COVID-19 patients, and less so for outpatients (34%). Thrombotic and bleeding risk stratification prior to any treatment decision is the cornerstone of all suggested thromboprophylaxis strategies; 81% of the documents recommend thromboprophylaxis for all hospitalized patients with a prophylactic dosage of low molecular weight heparin irrespective of VTE risk. Intermediate or therapeutic dose intensity is recommended in high VTE risk patients by 56% and 28% of documents, respectively. Mechanical thromboprophylaxis is suggested in case of high bleeding risk or contraindication to pharmacological thromboprophylaxis (59% of documents). Extended pharmacological thromboprophylaxis is recommended for patients with high VTE risk after hospital discharge (63% of documents). For non-hospitalized outpatients, 28% of documents recommend pharmacological thromboprophylaxis for high VTE risk. Conclusion: The current guidance identifies thromboprophylaxis in COVID-19 patients, especially during hospitalization, as of major importance for the prevention of VTE. Recommendations are derived from limited evidence from observational studies.

scholarly journals Surgery for constipation: systematic review and clinical guidance

2017 ◽  
Vol 19 ◽  
pp. 3-4 ◽  
Author(s):  
Neil J Smart ◽  
Steven Wexner
Keyword(s):  
Systematic Review ◽  
Clinical Guidance

scholarly journals COVID-19 management in social care in England: a systematic review of changing policies and newspaper reported staff perspectives.

2021 ◽  
Author(s):  
Lavinia Bertini ◽  
Leanne Bogen-Johnston ◽  
Jo Middleton ◽  
Wendy Wood ◽  
Shanu Sadhwani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Infection Control ◽  
Social Care ◽  
Control Measures ◽  
Care Staff ◽  
Emerging Infections ◽  
Public Attention ◽  
Infection Control Measures ◽  
Guidance Documents ◽  
Guidance Needs

Adult social care has been a major focus of public attention and infection control guidance during the COVID-19 pandemic, with a high mortality both for carers and those receiving care. To protect themselves and others from infection, staff in residential and domiciliary care settings had to quickly adapt to infection control measures that heavily impacted on their working and every-day life, whilst navigating new responsibilities, uncertainties and anxieties. We sought to explore the production and reception of guidance and look at ways these can be adapted to improve the working life of care staff in domiciliary and residential care whilst reducing the risk of SARS-CoV-2 transmission amid this pandemic and of future emerging infections. We conducted two complementary and integrated systematic reviews of published documents in the pre-vaccination era: (1) National guidance for social care (conducted between 29 July to 28 October 2020), and (2) Newspaper coverage of infection control issues in social care (conducted between 27th July to 10th September 2020). Three higher order common themes emerged in the integrated systematic review of guidance documents and newspaper articles: a) Testing, b) Personal Protective Equipment, c) Employment. The reviews revealed a sharp disjunction between the content of infection control guidance and its usability and applicability in social care settings. We suggest that infection control guidance needs to be better adapted to social care settings and informed by the sector. The practicalities of care work and care settings need to be at the core of the process for guidance to be relevant and effective. Modes and timings of communications also need to be optimised.

scholarly journals Suppurative thyroiditis: systematic review and clinical guidance

2021 ◽  
Author(s):  
Nicole Lafontaine ◽  
Diana Learoyd ◽  
Stephen Farrel ◽  
Rosemary Wong
Keyword(s):  
Systematic Review ◽  
Suppurative Thyroiditis ◽  
Clinical Guidance

scholarly journals COVID-19 transmission during swimming-related activities: a rapid systematic review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sally Yaacoub ◽  
Joanne Khabsa ◽  
Rayane El-Khoury ◽  
Amena El-Harakeh ◽  
Tamara Lotfi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research Evidence ◽  
Health Management ◽  
Management Strategies ◽  
Opportunity To Learn ◽  
Personal Hygiene ◽  
Protective Equipment ◽  
Raising Awareness ◽  
Guidance Documents ◽  
Indoor Spaces

Abstract Background There are uncertainties about mitigating strategies for swimming-related activities in the context of the COVID-19 pandemic. There is an opportunity to learn from the experience of previous re-openings to better plan the future one. Our objectives are to systematically review the evidence on (1) the association between engaging in swimming-related activities and COVID-19 transmission; and (2) the effects of strategies for preventing COVID-19 transmission during swimming-related activities. Methods We conducted a rapid systematic review. We searched in the L·OVE (Living OVerview of Evidence) platform for COVID-19. The searches covered the period from the inception date of each database until April 19, 2021. We included non-randomized studies for the review on association of COVID-19 transmission and swimming-related activities. We included guidance documents reporting on the strategies for prevention of COVID-19 transmission during swimming-related activities. We also included studies on the efficacy and safety of the strategies. Teams of two reviewers independently assessed article eligibility. For the guidance documents, a single reviewer assessed the eligibility and a second reviewer verified the judgement. Teams of two reviewers extracted data independently. We summarized the findings of included studies narratively. We synthesized information from guidance documents according to the identified topics and subtopics, and presented them in tabular and narrative formats. Results We identified three studies providing very low certainty evidence for the association between engaging in swimming-related activities and COVID-19 transmission. The analysis of 50 eligible guidance documents identified 11 topics: ensuring social distancing, ensuring personal hygiene, using personal protective equipment, eating and drinking, maintaining the pool, managing frequently touched surfaces, ventilation of indoor spaces, screening and management of sickness, delivering first aid, raising awareness, and vaccination. One study assessing the efficacy of strategies to prevent COVID-19 transmission did not find an association between compliance with precautionary restrictions and COVID-19 transmission. Conclusions There are major gaps in the research evidence of relevance to swimming-related activities in the context of the COVID-19 pandemic. However, the synthesis of the identified strategies from guidance documents can inform public health management strategies for swimming-related activities, particularly in future re-opening plans.

Sign in / Sign up

Export Citation Format

Share Document