CHAPTER 23. Challenges for the Early Detection of Degenerative Cartilage Changes Using Magnetic Resonance Imaging In vivo in Humans

Author(s):  
Matthew C. Gallo ◽  
Hsiang-Ling Teng ◽  
Sharmila Majumdar
Circulation ◽  
1985 ◽  
Vol 71 (3) ◽  
pp. 587-594 ◽  
Author(s):  
P W Pflugfelder ◽  
G Wisenberg ◽  
F S Prato ◽  
S E Carroll ◽  
K L Turner

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S692-S692
Author(s):  
Mathias Hoehn ◽  
Uwe Himmelreich ◽  
Ralph Weber ◽  
Pedro Ramos-Cabrer ◽  
Susanne Wegener ◽  
...  

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>


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