CHAPTER 2. Inclusion Complexes of Neutral Molecules in Aqueous Solution

2016 ◽  
pp. 52-105
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complexes

scholarly journals Effect of pH on the Conformation of Inclusion Complexes between β-Lactam Antibiotics and β-Cyclodextrins in Aqueous Solution

2010 ◽  
Vol 67 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Miho YUKAWA ◽  
Hanae MORIWAKI ◽  
Taichi MURAKAMI ◽  
Hirohito IKEDA ◽  
Yukiko IWASE ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complexes ◽  
Effect Of Ph

Evaluation of the phase solubility of inclusion complexes of diisopropylphenol (INN) with hydroxypropyl-β-cyclodextrin

2021 ◽  
pp. 27-32
Author(s):  
Olga Mikhailovna Balakhonova ◽  
Viktoriya Sergeevna Tyukova ◽  
Stanislav Anatolievich Kedik
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Tween 80 ◽  
Phase Solubility ◽  
Cyclodextrin Inclusion ◽  
Solubility Method ◽  
Cyclodextrin Inclusion Complex ◽  
The Stability ◽  
Solubility Profiles

The paper presents the results of a study of the stability of aqueous solutions of inclusion complexes of hydroxypropyl-β-cyclodextrin with diisopropylphenol in various systems by the Higuchi-Connors phase solubility method. The phase solubility profiles for each system corresponding to the AN type are determined graphically, and the stability constants of the resulting inclusion complexes are calculated. An aqueous solution containing 0.2 % Tween 80 and 0.2 % mannitol was selected as the optimal condition for obtaining the hydroxypropyl-β-cyclodextrin inclusion complex with diisopropylphenol.

scholarly journals NMR spectroscopic study of inclusion complexes of cetirizine dihydrochloride and β-cyclodextrin in solution

2007 ◽  
Vol 21 (3) ◽  
pp. 177-182 ◽  
Author(s):  
Syed Mashhood Ali ◽  
Santosh Kumar Upadhyay ◽  
Arti Maheshwari
Keyword(s):  
Aqueous Solution ◽  
Chemical Shift ◽  
Spectroscopic Study ◽  
Inclusion Complexes ◽  
Binding Constant ◽  
Spectroscopic Studies ◽  
Chemical Shift Change ◽  
Nmr Chemical Shift ◽  
H Nmr ◽  
Shift Change

Cetirizine dihydrochloride (CTZ), an antihistamine, forms two 1:1 inclusion complexes with β-cyclodextrin (β-CD) in aqueous solution as confirmed by detailed1H NMR, COSY and ROESY spectroscopic studies. The stoichiometry and overall binding constant of the complexes were determined by the treatment of1H NMR chemical shift change (Δδ) data. Most of the CTZ protons exhibited splitting in the presence of β-CD.

scholarly journals Cyclodextrin Complexation as a Way of Increasing the Aqueous Solublity and Staility of Carvedilol

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1746
Author(s):  
Sébastien Rigaud ◽  
David Mathiron ◽  
Tarek Moufawad ◽  
David Landy ◽  
Florence Djedaini-Pilard ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Aqueous Medium ◽  
Inclusion Complexes ◽  
Chemical Stability ◽  
Aqueous Media ◽  
Oral Formulation ◽  
Acid Ph ◽  
Cyclodextrin Complexation ◽  
Photochemical Stability

We studied the effect of several CDs on carvedilol’s solubility and chemical stability in various aqueous media. Our present results show that it is possible to achieve a carvedilol concentration of 5 mg/mL (12.3 mM) in the presence of 5 eq of γCD or RAMEB in an aqueous medium with an acceptable acid pH (between 3.5 and 4.7). Carvedilol formed 1:1 inclusion complexes but those with RAMEB appear to be stronger (K = 317 M−1 at 298 K) than that with γCD (K = 225 M−1 at 298 K). The complexation of carvedilol by RAMEB significantly increased the drug’s photochemical stability in aqueous solution. These results might constitute a first step towards the development of a novel oral formulation of carvedilol.

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