Chapter 4. The Discovery of OSI-906, a Small-molecule Inhibitor of the Insulin-like Growth Factor-1 and Insulin Receptors

Accounts in Drug Discovery ◽

10.1039/9781849731980-00071 ◽

2010 ◽

pp. 71-102

Author(s):

Mark J. Mulvihill ◽

Elizabeth Buck

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Insulin Receptors ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Molecule Inhibitor

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-09-0499 ◽

2009 ◽

Vol 8 (12) ◽

pp. 3341-3349 ◽

Author(s):

Joan M. Carboni ◽

Mark Wittman ◽

Zheng Yang ◽

Francis Lee ◽

Ann Greer ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Molecule Inhibitor

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Abstract 2740: Antitumor activity of BMS-754807, a small molecule inhibitor of insulin-like growth factor-1 receptor / insulin receptor, in combination with gemcitabine in pancreatic cancer

10.1158/1538-7445.am2012-2740 ◽

2012 ◽

Author(s):

Niranjan Awasthi ◽

Changhua Zhang ◽

Margaret A. Schwarz ◽

Roderich E. Schwarz

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Antitumor Activity ◽

Insulin Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Molecule Inhibitor

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BMS-754807, a Small-Molecule Inhibitor of Insulin-like Growth Factor-1 Receptor/Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-12-0447 ◽

2012 ◽

Vol 11 (12) ◽

pp. 2644-2653 ◽

Author(s):

Niranjan Awasthi ◽

Changhua Zhang ◽

Winston Ruan ◽

Margaret A. Schwarz ◽

Roderich E. Schwarz

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Insulin Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Molecule Inhibitor

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Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model

Cancer Research ◽

10.1158/0008-5472.can-10-0391 ◽

2010 ◽

Vol 70 (18) ◽

pp. 7221-7231 ◽

Author(s):

Fei Huang ◽

Warren Hurlburt ◽

Ann Greer ◽

Karen A. Reeves ◽

Stephen Hillerman ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Acquired Resistance ◽

Antibody Therapy ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Receptor Antibody ◽

Factor I ◽

Molecule Inhibitor ◽

Resistance To Insulin

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Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-2530 ◽

2009 ◽

Vol 15 (9) ◽

pp. 3058-3067 ◽

Author(s):

Peter Sabbatini ◽

Jason L. Rowand ◽

Arthur Groy ◽

Susan Korenchuk ◽

Qi Liu ◽

...

Keyword(s):

Growth Factor ◽

Antitumor Activity ◽

Tyrosine Kinase ◽

Small Molecule ◽

Receptor Tyrosine Kinase ◽

Small Molecule Inhibitor ◽

Insulin Like Growth Factor ◽

Factor I ◽

Molecule Inhibitor ◽

Growth Factor I

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AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma

Cancer Research ◽

10.1158/0008-5472.can-06-0284 ◽

2006 ◽

Vol 66 (17) ◽

pp. 8722-8730 ◽

Author(s):

Sith Sathornsumetee ◽

Anita B. Hjelmeland ◽

Stephen T. Keir ◽

Roger E. McLendon ◽

David Batt ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Malignant Glioma ◽

Small Molecule ◽

Growth Factor Receptor ◽

Small Molecule Inhibitor ◽

Vascular Endothelial ◽

Molecule Inhibitor ◽

Endothelial Growth Factor

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Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons

Journal of Neuroscience Research ◽

10.1002/jnr.22552 ◽

2010 ◽

Vol 89 (3) ◽

pp. 381-393 ◽

Author(s):

Nozomu Yoshioka ◽

Junko Kimura-Kuroda ◽

Taro Saito ◽

Koki Kawamura ◽

Shin-ichi Hisanaga ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Small Molecule Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor ◽

Injured Brain ◽

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PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

10.1186/1471-2407-9-411 ◽

2009 ◽

Vol 9 (1) ◽

Author(s):

Hal E Crosswell ◽

Anindya Dasgupta ◽

Carlos S Alvarado ◽

Tanya Watt ◽

James G Christensen ◽

...

Keyword(s):

Growth Factor ◽

Hepatocyte Growth Factor ◽

Small Molecule ◽

Neuroblastoma Cells ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Hepatocyte Growth

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Antiangiogenic and Antitumor Activity of 6-(2-Aminoethyl)Amino-5-Chlorouracil, a Novel Small-Molecule Inhibitor of Thymidine Phosphorylase, in Combination with the Vascular Endothelial Growth Factor-Trap

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-3203 ◽

2009 ◽

Vol 15 (16) ◽

pp. 5136-5144 ◽

Author(s):

Haiyan Lu ◽

Robert S. Klein ◽

Edward L. Schwartz

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Antitumor Activity ◽

Small Molecule ◽

Thymidine Phosphorylase ◽

Small Molecule Inhibitor ◽

Vascular Endothelial ◽

Molecule Inhibitor ◽

Endothelial Growth Factor

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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Drug Design Development and Therapy ◽

10.2147/dddt.s86621 ◽

2015 ◽

pp. 4479 ◽

Author(s):

Michael Lahn ◽

Stephan Herbertz ◽

J. Scott Sawyer ◽

Anja J Stauber ◽

Ivelina Gueorguieva ◽

...

Keyword(s):

Growth Factor ◽

Signaling Pathway ◽

Small Molecule ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Small Molecule Inhibitor ◽

Clinical Development ◽

Molecule Inhibitor ◽

Growth Factor Beta

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