Comparative study of certified reference materials and quality control materials for the quality assurance of blood-lead determination

Abstract Reference materials represent an invaluable tool for analytical quality control. Certified Reference Materials (CRMs) are used for the validation of methods, whereas various types of (uncertified) Reference Materials (RMs) are used for routine quality control (establishment of control charts) and interlaboratory testing (e.g., proficiency testing). This paper provides background information on the production and use of environmental RMs and describes recent CRMs produced by the BCR (European Commission) for quality assurance in environmental analysis.

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From Parochial to International

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/72.1.1 ◽

1989 ◽

Vol 72 (1) ◽

pp. 1-5

Author(s):

Alex Williams

Keyword(s):

Quality Assurance ◽

Reference Materials ◽

Analytical Methods ◽

Certified Reference Materials ◽

Analytical Measurement ◽

Require Data

Abstract The customers for analytical measurement services have international requirements; they require data of proven validity that will be accepted internationally. This means that well researched and tested analytical methods must gain better international acceptance. The methods should be capable of producing results to the accuracy required by the customer. They need to be supported by the use of appropriate certified reference materials, and the analyst, in reporting results, should give an estimate of the accuracy obtained. In addition, an independent accreditation is needed of the quality assurance procedures of the laboratory to assure customers that the analytical methods have been used correctly.

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Experience with Certified Reference Material Proficiency Testing for Quality Control of Wheat

Journal of Near Infrared Spectroscopy ◽

10.1255/jnirs.166 ◽

1998 ◽

Vol 6 (A) ◽

pp. A53-A61

Author(s):

Judit Budai ◽

Judit Fükó

Keyword(s):

Quality Control ◽

Reference Material ◽

Proficiency Testing ◽

Reference Materials ◽

Certified Reference Material ◽

Certified Reference Materials ◽

Long Term Stability ◽

Determining Factors ◽

Chemical Section

The Chemical Section of OMH1,2 embarked on the preparation of a series of wheat samples as Certified Reference Materials (CRMs) in 1992. The certification processes were carried out according to the recommendations of ISO. Since then we have developed a series of flour samples as well. The investigations of the long-term stability and the application of wheat and flour CRMs are continuous. Wheat is one of the most widely grown crops in Hungary and it is one of the major determining factors of the economy. Its uniform and objective qualification is of great importance. There are well-equipped laboratories available with sufficient experience but, as the proficiency testing regularly showed, certified samples need to be used to achieve exact and uniform measuring results.

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Transferability of blood lead determinations by furnace atomic absorption spectrophotometry and continuum background correction

Clinical Chemistry ◽

10.1093/clinchem/41.10.1451 ◽

1995 ◽

Vol 41 (10) ◽

pp. 1451-1454 ◽

Cited By ~ 7

Author(s):

H Qiao ◽

P J Parsons ◽

W Slavin

Keyword(s):

Detection Limit ◽

Atomic Absorption ◽

Reference Materials ◽

Human Blood ◽

Blood Lead ◽

Atomic Absorption Spectrophotometry ◽

Absorption Spectrophotometry ◽

Blood Specimens ◽

Blood Lead Determination ◽

The Continuum

Abstract We have examined and proved feasible the transfer of a method for blood lead determination, developed and optimized for a Zeeman-corrected instrument, to a continuum-corrected furnace atomic absorption spectrophotometer. Numerous reference materials analyzed with the continuum-corrected instrument gave results within 10 micrograms/L (0.05 mumol/L) at low values and varied by < 6% at values > 200 micrograms/L (0.97 mumol/L). Forty-four routine human blood specimens were analyzed by the same method with both continuum- and Zeeman-corrected instrumentation, and gave results that agreed within about the same limits as found with reference materials. The day-to-day precision was about 1/5 the accuracy results. The detection limit was approximately 5 micrograms/L (0.025 mumol/L).

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Quality Assurance of Analytical Measurements—A Vital Element in Safety Performance in the Nuclear Field

Proceedings ◽

10.3390/proceedings2020055002 ◽

2020 ◽

Vol 55 (1) ◽

pp. 2

Author(s):

Elena Neacsu

Keyword(s):

Quality Assurance ◽

Reference Materials ◽

Certified Reference Materials ◽

Analytical Data ◽

Physical Principle ◽

Energy Agency ◽

Nuclear Domain ◽

Analyte Detection ◽

Harmful Effects

The (International Atomic Energy Agency) IAEA’s fundamental safety objective is to protect people and the environment from harmful effects of ionizing radiation. The safety principles apply to all facilities and all activities to reduce existing radiation risks. Analytical quality assurance has gained in importance in many scientific areas, including the analysis of radioactive specimens that require a thorough investigation and regulations for safety and ecological reasons. The use of certified reference materials is an essential pillar for the assessment of the quality of analytical data. Still, such matrix-matched certified reference materials are unfortunately not available for most investigations relevant to the nuclear domain. Therefore, other strategies have to be established, i.e., to compare the analytical results obtained for a particular instrumental technique, with data from another methodology whose analyte detection is based on a different physical principle.

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