scholarly journals A simple method for the synthesis of hyaluronic acid coated magnetic nanoparticles for highly efficient cell labelling and in vivo imaging

RSC Advances ◽  
2011 ◽  
Vol 1 (8) ◽  
pp. 1449 ◽  
Author(s):  
Mohammad H. El-Dakdouki ◽  
Kheireddine El-Boubbou ◽  
David C. Zhu ◽  
Xuefei Huang
2015 ◽  
Vol 833 ◽  
pp. 75-78
Author(s):  
Gang An ◽  
Dong Ying Ju ◽  
Takashi Kumazawa

As a delivery carrier, the nanoparticles are broadly applied in various fields for excellent infiltration characteristics. In recent years, there has been new rearch was investigated in the medical area, but the research of influence on a living body is seldom studied. In this study, the influence on the living body as new transdermal carrier system using magnetic nanoparticles was investigated. The application of magnetic nanoparticles coated medication on the mice model investigated that the effect of treatment on the atopic dermatitis. The skin tissues were stained, and the section of skin tissues was observed by the optical Microscope. In vivo efficacy studies in mice model revealed highly efficient improvement of AD-like skin lesions. Furthermore the magnetic nanoparticles are useful as novel delivery drug carrier via human dermal papilla cell experiment. The results indicated that the magnetic nanoparticles are useful as new the transdermal carrier , and it proved that it is a highly efficient system useful as novel medicine delivery system.


2019 ◽  
Vol 55 (42) ◽  
pp. 5851-5854 ◽  
Author(s):  
Lianhua Liu ◽  
Yaping Yuan ◽  
Yuqi Yang ◽  
Michael T. McMahon ◽  
Shizhen Chen ◽  
...  

A fluorinated aza-BODIPY derivative BDPF was developed as a small molecule contrast agent, which displayed highly efficient near infrared fluorescence/photoacoustic/19F MR tri-modality tumor imaging.


2012 ◽  
Vol 7 (10) ◽  
pp. 677-682 ◽  
Author(s):  
Debadyuti Ghosh ◽  
Youjin Lee ◽  
Stephanie Thomas ◽  
Aditya G. Kohli ◽  
Dong Soo Yun ◽  
...  

2016 ◽  
Vol 8 (39) ◽  
pp. 25650-25653 ◽  
Author(s):  
Xin Zhang ◽  
Meinan Yao ◽  
Muhua Chen ◽  
Liqiang Li ◽  
Chengyan Dong ◽  
...  

2005 ◽  
Vol 127 (30) ◽  
pp. 10676-10685 ◽  
Author(s):  
Marie-Sophie Martina ◽  
Jean-Paul Fortin ◽  
Christine Ménager ◽  
Olivier Clément ◽  
Gillian Barratt ◽  
...  

2009 ◽  
Vol 16 (1) ◽  
pp. 86 ◽  
Author(s):  
Huey-Chung Huang ◽  
Po-Yuan Chang ◽  
Karen Chang ◽  
Chao-Yu Chen ◽  
Chung-Wu Lin ◽  
...  

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3070
Author(s):  
Hyeon Jin Ju ◽  
Mina Park ◽  
Ji Hoon Park ◽  
Gi Ru Shin ◽  
Hak Soo Choi ◽  
...  

In this study, we developed injectable intratympanic hyaluronic acid (HA) depots for the treatment of hearing loss. We prepared an injectable click-crosslinking formulation by modifying HA with tetrazine (HA-TET) and trans-cyclooctene (HA-TCO), which crosslinked to form an HA depot (Cx-HA). Preparation of the click-crosslinking HA formulation was facile, and Cx-HA depot formation was reproducible. Additionally, the Cx-HA hydrogel was significantly stiffer than HA hydrogel. To monitor the degradation pattern of hydrogels, we mixed a zwitterionic near-infrared (NIR) fluorophore (e.g., ZW800-1C) in the click-crosslinking HA formulation. Then, HA-TET and HA-TCO solutions containing ZW800-1C were loaded separately into the compartments of a dual-barrel syringe for intratympanic injection. The Cx-HA depots formed quickly, and an extended residence time in the tympanic cavity was confirmed by performing NIR fluorescence imaging. We have successfully prepared an injectable click-crosslinking HA formulation that has promise as an intratympanic drug depot.


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