A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/19F MR tri-modality in vivo imaging

2019 ◽  
Vol 55 (42) ◽  
pp. 5851-5854 ◽  
Author(s):  
Lianhua Liu ◽  
Yaping Yuan ◽  
Yuqi Yang ◽  
Michael T. McMahon ◽  
Shizhen Chen ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Small Molecule ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Near Infrared Fluorescence ◽  
Highly Efficient ◽  
Nir Fluorescence

A fluorinated aza-BODIPY derivative BDPF was developed as a small molecule contrast agent, which displayed highly efficient near infrared fluorescence/photoacoustic/19F MR tri-modality tumor imaging.

In vivo imaging with near-infrared fluorescence lifetime contrast

2009 ◽  
Author(s):  
Walter J. Akers ◽  
Mikhail Y. Berezin ◽  
Hyeran Lee ◽  
Samuel Achilefu
Keyword(s):  
Fluorescence Lifetime ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence

scholarly journals Imaging: Conjugated Polymer/Photochromophore Binary Nanococktails: Bistable Photoswitching of Near-Infrared Fluorescence for In Vivo Imaging (Adv. Mater. 39/2013)

2013 ◽  
Vol 25 (39) ◽  
pp. 5521-5521
Author(s):  
Keunsoo Jeong ◽  
Solji Park ◽  
Yong-Deok Lee ◽  
Chang-Keun Lim ◽  
Jungahn Kim ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Near Infrared Fluorescence

scholarly journals Rational design of a NIR-II fluorescent nano-system with maximized fluorescence performance and applications

2021 ◽  
Author(s):  
Haoli Yu ◽  
Yuesong Wang ◽  
Yan Chen ◽  
Min Ji
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Nir Fluorescence

Purpose: Near-infrared (NIR) fluorescence imaging (FI) become a research hotspot in the field of in vivo imaging. Here, we intend to synthesize a NIR-II fluorescence nano-system with an excellent fluorescence...

Near-infrared Emitting Gold-silver Nanoclusters with Large Stokes Shift for Two-Photon in Vivo Imaging

2021 ◽  
Author(s):  
Yaowei Peng ◽  
Xiaoyu Huang ◽  
Fu Wang
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Silver Nanoclusters ◽  
One Pot ◽  
Two Photon ◽  
Nir Fluorescence ◽  
Gold Silver ◽  
Stokes Shifts

Near-infrared emitting bi-metallic gold/silver nanoclusters with great stokes shifts were manufactured through one-pot synthesis. The gold/silver nanoclusters exhibit strong NIR fluorescence due to the silver effect, which can be applied...

scholarly journals Multimodal Mn-doped I–III–VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9264-9272 ◽  
Author(s):  
Gary Sitbon ◽  
Sophie Bouccara ◽  
Mariana Tasso ◽  
Aurélie Francois ◽  
Lina Bezdetnaya ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Resonance Imaging ◽  
Near Infrared Fluorescence ◽  
Nir Fluorescence ◽  
Mn Doped

Cadmium-free quantum dots doped with Mn2+ions show promising results forin vivobimodal MRI and NIR fluorescence imaging.

scholarly journals High-affinity Near-infrared Fluorescent Small-molecule Contrast Agents for In Vivo Imaging of Prostate-specific Membrane Antigen

2005 ◽  
Vol 4 (4) ◽  
pp. 7290.2005.05163 ◽  
Author(s):  
Valerie Humblet ◽  
Rena Lapidus ◽  
Larry R. Williams ◽  
Takashi Tsukamoto ◽  
Camilo Rojas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Expression System ◽  
High Yield ◽  
Definitive Treatment ◽  
Fluorescent Light ◽  
High Affinity

Surgical resection remains a definitive treatment for prostate cancer. Yet, prostate cancer surgery is performed without image guidance for tumor margin, extension beyond the capsule and lymph node positivity, and without verification of other occult metastases in the surgical field. Recently, several imaging systems have been described that exploit near-infrared (NIR) fluorescent light for sensitive, real-time detection of disease pathology intraoperatively. In this study, we describe a high-affinity (9 nM), single nucleophile-containing, small molecule specific for the active site of the enzyme PSMA. We demonstrate production of a tetra-sulfonated heptamethine indocyanine NIR fluorescent derivative of this molecule using a high-yield LC/MS purification strategy. Interestingly, NIR fluorophore conjugation improves affinity over 20-fold, and we provide mechanistic insight into this observation. We describe the preparative production of enzymatically active PSMA using a baculovirus expression system and an adenovirus that co-expresses PSMA and GFP. We demonstrate sensitive and specific in vitro imaging of endogenous and ectopically expressed PSMA in human cells and in vivo imaging of xenograft tumors. We also discuss chemical strategies for improving performance even further. Taken together, this study describes nearly complete preclinical development of an optically based small-molecule contrast agent for image-guided surgery.

In vivo imaging of tumour bearing near-infrared fluorescence-emitting carbon nanodots derived from tire soot

2013 ◽  
Vol 49 (87) ◽  
pp. 10290 ◽  
Author(s):  
Hae Young Ko ◽  
Young Wook Chang ◽  
Gokul Paramasivam ◽  
Myoung Seok Jeong ◽  
Sujeong Cho ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Carbon Nanodots ◽  
Near Infrared Fluorescence ◽  
Tumour Bearing

Wide-field near-infrared fluorescence endoscope for real-time in vivo imaging

2012 ◽  
Author(s):  
Zhongyao Liu ◽  
Sharon J. Miller ◽  
Bishnu P. Joshi ◽  
Thomas D. Wang
Keyword(s):  
Real Time ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Wide Field ◽  
Near Infrared Fluorescence
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