Effect of physical state (solid vs. liquid) of lipid core on the rate of transport of oxygen and free radicals in solid lipid nanoparticles and emulsion

Soft Matter ◽  
2011 ◽  
Vol 7 (18) ◽  
pp. 8149 ◽  
Author(s):  
Rohan V. Tikekar ◽  
N. Nitin
Keyword(s):  
Free Radicals ◽  
Solid Lipid Nanoparticles ◽  
Physical State ◽  
Lipid Nanoparticles ◽  
Lipid Core ◽  
Solid Lipid

Formation of transparent solid lipid nanoparticles by microfluidization: Influence of lipid physical state on appearance

2015 ◽  
Vol 448 ◽  
pp. 114-122 ◽  
Author(s):  
Thrandur Helgason ◽  
Hanna Salminen ◽  
Kristberg Kristbergsson ◽  
David Julian McClements ◽  
Jochen Weiss
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physical State ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Preparation of solid lipid nanoparticles through various methods using different precursors

2019 ◽  
Vol 9 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Richa Singh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Drug Dose ◽  
Pharmacokinetic Property ◽  
Lipid Core ◽  
Solid Lipid ◽  
Novel Approach

Now a day there has been exponential increase in interest in developing nanoparticles for novel drug delivery system. Nanoparticles provide many advantages over conventional drug delivery system like improved pharmacokinetic property; enhance bioavailability, smaller drug dose required for the treatment. Recently solid lipid nanoparticles (SLN) materialized as novel approach to oral and parenteral drug delivery system. SLN possess a solid lipid core that can solubilise lipophilic drug. Lipid core was stabilised by using surfactant (emulsifier). SLN can be prepared by using various precursors like emulsion, micro emulsion, and SLM can be prepared by using lipid coated microcrystal. These precursors further proceed to obtain particles of desired size and shape by making use of various techniques and equipment’s. Each precursor show benefits along with some limitations. Keywords: solid lipid nanoparticles, SLN precursors, membrane contractor, spray dry and congealing, GAMA.

Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery

2009 ◽  
Vol 5 (2) ◽  
pp. 184-191 ◽  
Author(s):  
Rishi Paliwal ◽  
Shivani Rai ◽  
Bhuvaneshwar Vaidya ◽  
Kapil Khatri ◽  
Amit K. Goyal ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Core Material ◽  
Lipid Core ◽  
Solid Lipid ◽  
Lymphatic Delivery

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Sign in / Sign up

Export Citation Format

Share Document