Protective effect of Öküzgözü (Vitis vinifera L. cv.) grape juice against carbon tetrachloride induced oxidative stress in rats

The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ability to affect cellular viability and oxidative stress parameters in embryonic cardiomyocyte cells (H9c2), and human breast adenocarcinoma cell line (MCF-7) exposed to doxorubicin. Interestingly, we found that the mix resulting from Citrus sinensis and Vitis vinifera association in ratio 1:1 was able to reduce cardiomyocytes damage induced by anthracyclines, without significantly interfering with the pro-apoptotic activity of the drug on breast cancer cells. These results point out the potential use of vegetable smoothies as adjuvants functional foods for chemotherapeutic anticancer protocols.

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The potential protective effect of Commelina nudiflora L. against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, mediated by suppression of oxidative stress and inflammation

Environmental Health and Preventive Medicine ◽

10.1186/s12199-017-0673-0 ◽

2017 ◽

Vol 22 (1) ◽

Cited By ~ 13

Author(s):

Muhammad Dawood Shah ◽

Urban J.A. D’Souza ◽

Mohammad Iqbal

Keyword(s):

Oxidative Stress ◽

Carbon Tetrachloride ◽

Protective Effect

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Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats

Biomarkers ◽

10.1080/1354750x.2019.1691266 ◽

2019 ◽

Vol 25 (1) ◽

pp. 48-61 ◽

Cited By ~ 2

Author(s):

Nabil Saadaoui ◽

Asma Weslati ◽

Taha Barkaoui ◽

Ikram Khemiri ◽

Wafa Gadacha ◽

...

Keyword(s):

Oxidative Stress ◽

Vitis Vinifera ◽

Leaf Extract ◽

Vitis Vinifera L ◽

Gastroprotective Effect

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Soil type affects grape juice free amino acids profile during ripening of cv. Malvasia Istriana (Vitis vinifera L.)

New Zealand Journal of Crop and Horticultural Science ◽

10.1080/01140671.2019.1657910 ◽

2019 ◽

Vol 48 (1) ◽

pp. 22-33 ◽

Cited By ~ 1

Author(s):

Igor Palčić ◽

Ana-Marija Jagatić Korenika ◽

Snježana Jakobović ◽

Igor Pasković ◽

Nikola Major ◽

...

Keyword(s):

Amino Acids ◽

Vitis Vinifera ◽

Soil Type ◽

Free Amino Acids ◽

Free Amino ◽

Grape Juice ◽

Vitis Vinifera L ◽

Amino Acids Profile

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Protective effect of apricot (Prunus armeniacaL.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats

British Journal Of Nutrition ◽

10.1017/s0007114509991322 ◽

2009 ◽

Vol 102 (12) ◽

pp. 1767-1775 ◽

Cited By ~ 35

Author(s):

Feral Ozturk ◽

Mehmet Gul ◽

Burhan Ates ◽

I. Cetin Ozturk ◽

Asli Cetin ◽

...

Keyword(s):

Oxidative Stress ◽

Carbon Tetrachloride ◽

Protective Effect ◽

Hepatic Steatosis ◽

Wistar Rats ◽

Liver Steatosis ◽

Radical Scavenging ◽

Hepatic Necrosis ◽

Control Group ◽

Cytoplasmic Matrix

The present study was planned to investigate the protective effect of 10 % and 20 % apricot-containing feed on carbon tetrachloride (CCl4)-induced hepatic steatosis and damage. Adult male Wistar rats (n42) were divided into six groups of seven each, as follows: control group; CCl4group; CCl4+10 % apricot group; CCl4+20 % apricot group; 10 % apricot group; 20 % apricot group. All apricot groups were fed with 10 % or 20 % apricot-containing feed for 5 months. CCl4injections were applied to the CCl4groups at the dose of 1 mg/kg for 3 d at the end of 5 months. In the CCl4group, vacuolated hepatocytes and hepatic necrosis were seen, especially in the centrilobular area. Hepatocytes showed an oedematous cytoplasmic matrix, large lipid globules and degenerated organelles. The area of liver injury was found significantly decreased with apricot feeding. Malondialdehyde and total glutathione levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4group and indicated increased oxidative stress. Apricot feeding decreased this oxidative stress and ameliorated histological damage. We concluded that apricot feeding had beneficial effects on CCl4-induced liver steatosis and damage probably due to its antioxidant nutrient (β-carotene and vitamin) contents and high radical-scavenging capacity. Dietary intake of apricot can reduce the risk of liver steatosis and damage caused by free radicals.

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