Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats

Biomarkers ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 48-61 ◽  
Author(s):  
Nabil Saadaoui ◽  
Asma Weslati ◽  
Taha Barkaoui ◽  
Ikram Khemiri ◽  
Wafa Gadacha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Leaf Extract ◽  
Vitis Vinifera L ◽  
Gastroprotective Effect

scholarly journals Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 378 ◽  
Author(s):  
Giacomo Pepe ◽  
Emanuela Salviati ◽  
Shara Francesca Rapa ◽  
Carmine Ostacolo ◽  
Stella Cascioferro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Citrus Sinensis ◽  
Breast Adenocarcinoma ◽  
Vitis Vinifera L ◽  
Stress Evaluation ◽  
Apoptotic Activity ◽  
And Oxidative Stress ◽  
Potential Use ◽  
Mcf 7

The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ability to affect cellular viability and oxidative stress parameters in embryonic cardiomyocyte cells (H9c2), and human breast adenocarcinoma cell line (MCF-7) exposed to doxorubicin. Interestingly, we found that the mix resulting from Citrus sinensis and Vitis vinifera association in ratio 1:1 was able to reduce cardiomyocytes damage induced by anthracyclines, without significantly interfering with the pro-apoptotic activity of the drug on breast cancer cells. These results point out the potential use of vegetable smoothies as adjuvants functional foods for chemotherapeutic anticancer protocols.

Protective effect of Öküzgözü (Vitis vinifera L. cv.) grape juice against carbon tetrachloride induced oxidative stress in rats

2012 ◽  
Vol 3 (6) ◽  
pp. 668 ◽  
Author(s):  
Mihdiye Pirinççioğlu ◽  
Göksel Kızıl ◽  
Murat Kızıl ◽  
Gültekin Özdemir ◽  
Zeki Kanay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Vitis Vinifera ◽  
Grape Juice ◽  
Vitis Vinifera L

scholarly journals Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases

Antioxidants ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 134 ◽  
Author(s):  
Enrico Sangiovanni ◽  
Chiara Di Lorenzo ◽  
Stefano Piazza ◽  
Yuri Manzoni ◽  
Cecilia Brunelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Water Extract ◽  
Ultraviolet B ◽  
Vitis Vinifera L ◽  
Mediators Of Inflammation ◽  
Tnf Α ◽  
And Oxidative Stress

Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve skin conditions. Dried red leaves from grapevine (Vitis vinifera L., cv Teinturiers) showed anti-inflammatory and anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated. In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H2O2) mediators. VVWE inhibited interleukin-8 (IL-8) secretion induced by proinflammatory stimuli, acting on the IL-8 promoter activity, but the effect was lower when prooxidant mediators were used. The effect was partly explained by the reduction of nuclear factor-κB (NF-κB)-driven transcription and nuclear translocation. Furthermore, vascular endothelial growth factor (VEGF) secretion, a regulator of angiogenesis, was inhibited by VVWE, but not matrix metalloproteinase-9 (MMP-9), a protease involved in matrix remodeling. VVWE, assayed on Franz diffusion cell system, showed a marked reduction of High Performance Liquid Chromatography (HPLC)-identified compounds. Pure molecules individually failed to reduce TNF-α-induced IL-8 release, suggesting synergistic effects or the presence of other bioactive compounds still unknown.

Oxidative stress prevention and anti-apoptosis activity of grape ( Vitis vinifera L.) stems in human keratinocytes

2016 ◽  
Vol 87 ◽  
pp. 92-102 ◽  
Author(s):  
Raúl Domínguez-Perles ◽  
Ana Guedes ◽  
Marcelo Queiroz ◽  
Amélia M. Silva ◽  
Ana I.R.N.A. Barros
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Human Keratinocytes ◽  
Vitis Vinifera L ◽  
Stress Prevention

Effects of dietary Corinthian currants (Vitis vinifera L., var. Apyrena) on atherosclerosis and plasma phenolic compounds during prolonged hypercholesterolemia in New Zealand White rabbits

2015 ◽  
Vol 6 (3) ◽  
pp. 963-971 ◽  
Author(s):  
Amalia E. Yanni ◽  
Vissarion Efthymiou ◽  
Pavlos Lelovas ◽  
George Agrogiannis ◽  
Nikolaos Kostomitsopoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
New Zealand ◽  
Phenolic Compounds ◽  
Animal Models ◽  
Vitis Vinifera ◽  
Vitis Vinifera L ◽  
New Zealand White Rabbits

Effects of dietary Corinthian currants on atherosclerosis, oxidative stress and plasma phenolic compounds in hypercholesterolemic animal models.

scholarly journals Oxidative stress homeostasis in grapevine (Vitis vinifera L.)

2015 ◽  
Vol 3 ◽  
Author(s):  
Luísa C. Carvalho ◽  
Patrícia Vidigal ◽  
Sara Amâncio
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Vitis Vinifera L

scholarly journals New Insights into the Exploitation of Vitis vinifera L. cv. Aglianico Leaf Extracts for Nutraceutical Purposes

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 708 ◽  
Author(s):  
Fabiana Labanca ◽  
Immacolata Faraone ◽  
Maria Rosaria Nolè ◽  
Ruth Hornedo-Ortega ◽  
Daniela Russo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Inhibitory Activity ◽  
Vitis Vinifera L ◽  
Ultrasound Assisted Extraction ◽  
Leaf Extracts ◽  
Assisted Extraction ◽  
Long Time ◽  
Bioactive Potential ◽  
First Time

The leaves of Vitis vinifera L. have been used for a long time in traditional medicine for the treatment of many ailments. Grape polyphenols, indeed, have been demonstrated to be able to defend against oxidative stress, responsible for various disorders such as cancer, diabetes and neurodegenerative diseases. The effects of different extraction techniques, Soxhlet (SOX), Accelerated Solvent (ASE 40, ASE 50) and Ultrasound Assisted Extraction (UAE) were studied in this work to evaluate their impact on the chemical profile and bioactive potential of Vitis vinifera L. (cv. Aglianico) leaf extracts. The phytochemical profile was investigated by HPLC-DAD and 9 phenolic compounds were identified and quantified in the extract. Moreover, the antioxidant, anticholinesterase and antityrosinase activities were evaluated. In detail, the total polyphenol content and antioxidant activity (2,2-diphenyl-1-picrylhydrazyl, Oxygen Radical Absorbance Capacities and β-Carotene Bleaching assays) were evaluated and compared to assess the Relative Antioxidant Capacity Index (RACI). To test the inhibitory activity of extracts towards cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition assays were performed. SOX and ASE 50 have shown the highest value of RACI, 0.76 and 0.65, respectively. Regarding enzymatic inhibitory activity, ASE 50 (IC50 = 107.16 ± 8.12 μg/mL) and SOX (IC50 = 171.34 ± 12.12 μg/mL) extracts exhibited the highest AChE and BChE inhibitory activity, respectively, while UAE (IC50 = 293.2 ± 25.6 μg/mL, followed by SOX (IC50 = 302.5 ± 38.3 μg/mL) showed the highest tyrosinase inhibition value. Our results demonstrated for the first time that Aglianico leaves are important sources of phenols that could be used to prevent oxidative stress and be potentially helpful in diseases treatable with tyrosinase and cholinesterase inhibitors, like myasthenia gravis or Alzheimer’s.

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