Tribological studies of stearic acid-modified CaCu2.9Zn0.1Ti4O12nanoparticles as effective zero SAPS antiwear lubricant additives in paraffin oil

2014 ◽  
Vol 2 (2) ◽  
pp. 375-386 ◽  
Author(s):  
Vinay Jaiswal ◽  
Rashmi B. Rastogi ◽  
Rajesh Kumar ◽  
Laxman Singh ◽  
K. D. Mandal
Keyword(s):  
Stearic Acid ◽  
Lubricant Additives ◽  
Paraffin Oil

scholarly journals Formulation Development and Evaluation of Liposphere of Poor Water Soluble Drug for Hyperlipidemia

2021 ◽  
Vol 11 (2) ◽  
pp. 23-30
Author(s):  
Anil Kumar ◽  
Umesh K. Jain ◽  
Ajay Patel
Keyword(s):  
Drug Release ◽  
Stearic Acid ◽  
Aqueous Solubility ◽  
Class Ii ◽  
Water Soluble ◽  
Fibric Acid Derivative ◽  
Formulation Development ◽  
Bcs Class Ii ◽  
Paraffin Oil

Lipospheres offer a new approach to improve an aqueous solubility of BCS class-II drugs. Simvastatin is a third generation fibric acid derivative belonging to this class, employed clinically as a hypolipidemic agent to lessen the risk caused by atherosclerosis. An attempt was made to improve aqueous solubility of Simvastatin by aid of stearic acid and Paraffin oil. The factorial batches of the Simvastatin lipospheres were formulated by melt dispersion technique using 32 factorial design with variables X1- concentration of stearic acid and X2- concentration of paraffin oil and responses Y1 - % Drug Entrapment (% DE) and Y2 - % Drug Release (% DR). From the surface response graphs the optimized batch was formulated and evaluated for saturation solubility, in-vitro drug release studies. Significant improvement in the aqueous solubility of the drug in the Simvastatin lipospheres supports the applicability of lipospheres as a tool for improving aqueous solubility of the BCS class-II drugs. Keywords: Linospheres; Simvastatin; Drug release; Hyperlipidemic; Drug entrapment.

Synthesis of O-(2-Deoxy-2-stearoylamino-β-D-glucopyranosyl)-(1→4)-N-acetylnormuramoyl-L-α-aminobutanoyl-D-isoglutamine, a Lipophilic Disaccharide Analogue of MDP

1992 ◽  
Vol 57 (3) ◽  
pp. 579-589 ◽  
Author(s):  
Miroslav Ledvina ◽  
David Šaman ◽  
Jan Ježek
Keyword(s):  
Stearic Acid ◽  
Benzyl Ester ◽  
Barium Hydroxide ◽  
High Yield

Partial N-deacetylation of compound II with barium hydroxide afforded benzyl 2-acetamido-3-O-allyl-4-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-6-O,-benzyl-2-deoxy-α-D-glucopyranoside (III) in high yield. Compound III was N-acylated with stearic acid in the presence of DCC and the obtained product was converted into benzyl 2-acetamido-6-O-benzyl-3-O-carboxymethyl-2-deoxy-4-O-(3,4,6-tri-O-benzyl-2-deoxy-2-stearoylamino-β-D-glucopyranosyl)-α-D-glucopyranoside (VII). Coupling of compound VII with L-α-aminobutanoyl-D-isoglutamine benzyl ester followed by hydrogenolysis of the product VIII afforded compound IX.

scholarly journals Water lubrication of graphene oxide-based materials

Friction ◽  
2021 ◽  
Author(s):  
Shaoqing Xue ◽  
Hanglin Li ◽  
Yumei Guo ◽  
Baohua Zhang ◽  
Jiusheng Li ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Graphene Oxide ◽  
Lubrication Theory ◽  
Lubricant Additives ◽  
Water Lubrication ◽  
Broad Application ◽  
Water Dispersibility ◽  
Metal Processing ◽  
The Relationship ◽  
Ph Concentration

AbstractWater is as an economic, eco-friendly, and efficient lubricant that has gained widespread attention for manufacturing. Using graphene oxide (GO)-based materials can improve the lubricant efficacy of water lubrication due to their outstanding mechanical properties, water dispersibility, and broad application scenarios. In this review, we offer a brief introduction about the background of water lubrication and GO. Subsequently, the synthesis, structure, and lubrication theory of GO are analyzed. Particular attention is focused on the relationship between pH, concentration, and lubrication efficacy when discussing the tribology behaviors of pristine GO. By compounding or reacting GO with various modifiers, amounts of GO-composites are synthesized and applied as lubricant additives or into frictional pairs for different usage scenarios. These various strategies of GO-composite generate interesting effects on the tribology behaviors. Several application cases of GO-based materials are described in water lubrication, including metal processing and bio-lubrication. The advantages and drawbacks of GO-composites are then discussed. The development of GO-based materials for water lubrication is described including some challenges.

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