Filamentous supramolecular peptide–drug conjugates as highly efficient drug delivery vehicles

2014 ◽  
Vol 50 (37) ◽  
pp. 4827-4830 ◽  
Author(s):  
Miao Yang ◽  
Dawei Xu ◽  
Linhai Jiang ◽  
Lin Zhang ◽  
Derek Dustin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Efficacy ◽  
Cancer Drug ◽  
Peptide Drug ◽  
Drug Delivery Vehicles ◽  
Drug Conjugates ◽  
Anti Cancer ◽  
Delivery Vehicles ◽  
Peptide Drug Conjugates

We report here a facile approach to prepare filamentous supramolecular peptide–drug conjugates with precise drug/carrier stoichiometry, nearly 100% loading efficiency and exceptional anti-cancer drug efficacy for chemotherapy.

scholarly journals Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

2019 ◽  
Vol 20 (2) ◽  
pp. 315 ◽  
Author(s):  
Eun Kang ◽  
Yu Baek ◽  
Eunil Hahm ◽  
Sang Lee ◽  
Xuan-Hung Pham ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Carrier ◽  
Silica Nanoparticle ◽  
Surface Modifications ◽  
Ag Nps ◽  
Drug Delivery Vehicles ◽  
Transmission Electron ◽  
Delivery Vehicles ◽  
Simple Surface

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

Albumin–Polymer–Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles

2016 ◽  
Vol 5 (10) ◽  
pp. 1089-1094 ◽  
Author(s):  
Anton A. A. Smith ◽  
Kaja Zuwala ◽  
Oliver Pilgram ◽  
Karen Singers Johansen ◽  
Martin Tolstrup ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Drug Conjugates ◽  
Delivery Vehicles ◽  
Polymer Drug Conjugates ◽  
High Payload

scholarly journals Nanocellulose as a Vehicle for Drug Delivery and Efficiency of Anticancer Activity: A Short-Review

2021 ◽  
Vol 1 (1) ◽  
pp. 30-43
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Short Review ◽  
Organic Polymer ◽  
Preparation Methods ◽  
Drug Delivery Vehicles ◽  
Research Fields ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Delivery Vehicles

With the high demand of using nanotechnology, nanocellulose has become popular for different biomedical and anticancer applications. Cellulose, a nature gifted material and the most abundant organic polymer on earth, is systematically reviewed. Details of the mechanical and chemical structure of nanocellulose are explained, starting with preparation methods along with physiochemical properties and pH gradient to incorporate innovative polymeric drug delivery vehicles in anticancer applications. A myriad of research fields has introduced nanocellulose as an intriguing candidate for anticancer drug excipient and carrier in modern cancer therapy. Albeit, innovative nanocellulose-based drug carrier systems will be complicated for their commercial use in pharmacies. Of this, it is required to understand the preparation, properties, and potential drug conjugation of nanocellulose to improve its interactions with human tissues.

scholarly journals HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging

2020 ◽  
Author(s):  
Betül Altunay ◽  
Agnieszka Morgenroth ◽  
Mohsen Beheshti ◽  
Andreas Vogg ◽  
Nicholas C. L. Wong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Monoclonal Antibodies ◽  
Molecular Imaging ◽  
Antibody Fragments ◽  
Drug Delivery Vehicles ◽  
Tumor Penetration ◽  
Drug Conjugates ◽  
Delivery Vehicles

Abstract Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including a detailed look at recent clinical data from antibody drug conjugates and nanobodies as well as affibodies that are currently under development. Results Clinical and preclinical studies have shown that the use of monoclonal antibodies in molecular imaging is impaired by slow blood clearance, associated with slow and low tumor uptake and with limited tumor penetration potential. Antibody fragments, such as nanobodies, on the other hand, can be radiolabelled with short-lived radioisotopes and provide high-contrast images within a few hours after injection, allowing early diagnosis and reduced radiation exposure of patients. Even in therapy, the small radioactively labeled nanobodies prove to be superior to radioactively labeled monoclonal antibodies due to their higher specificity and their ability to penetrate the tumor. Conclusion While monoclonal antibodies are well established drug delivery vehicles, the current literature on molecular imaging supports the notion that antibody fragments, such as affibodies or nanobodies, might be superior in this approach.

scholarly journals Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice

Nanomedicine ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. 1535-1546 ◽  
Author(s):  
Ashwin A Bhirde ◽  
Sachin Patel ◽  
Alioscka A Sousa ◽  
Vyomesh Patel ◽  
Alfredo A Molinolo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carbon Nanotube ◽  
Cancer Drug ◽  
Single Walled Carbon Nanotube ◽  
Drug Delivery Vehicles ◽  
Single Walled Carbon ◽  
Delivery Vehicles ◽  
Cancer Drug Delivery

Main-chain polyacetal conjugates with HIF-1 inhibitors: temperature-responsive, pH-degradable drug delivery vehicles

2018 ◽  
Vol 6 (4) ◽  
pp. 666-674 ◽  
Author(s):  
Sanjoy Samanta ◽  
Chathuranga C. De Silva ◽  
Porakrit Leophairatana ◽  
Jeffrey T. Koberstein
Keyword(s):  
Drug Delivery ◽  
Tumor Tissue ◽  
Main Chain ◽  
Drug Delivery Vehicles ◽  
Temperature Responsive ◽  
Drug Conjugates ◽  
Release Drug ◽  
Delivery Vehicles

Main-chain polyacetal drug conjugates are temperature responsive and pH degradable and can be designed to selectively target, retain and release drug in hyperthermic tumor tissue.

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