scholarly journals Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

2019 ◽  
Vol 20 (2) ◽  
pp. 315 ◽  
Author(s):  
Eun Kang ◽  
Yu Baek ◽  
Eunil Hahm ◽  
Sang Lee ◽  
Xuan-Hung Pham ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Carrier ◽  
Silica Nanoparticle ◽  
Surface Modifications ◽  
Ag Nps ◽  
Drug Delivery Vehicles ◽  
Transmission Electron ◽  
Delivery Vehicles ◽  
Simple Surface

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

scholarly journals Nanocellulose as a Vehicle for Drug Delivery and Efficiency of Anticancer Activity: A Short-Review

2021 ◽  
Vol 1 (1) ◽  
pp. 30-43
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Short Review ◽  
Organic Polymer ◽  
Preparation Methods ◽  
Drug Delivery Vehicles ◽  
Research Fields ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Delivery Vehicles

With the high demand of using nanotechnology, nanocellulose has become popular for different biomedical and anticancer applications. Cellulose, a nature gifted material and the most abundant organic polymer on earth, is systematically reviewed. Details of the mechanical and chemical structure of nanocellulose are explained, starting with preparation methods along with physiochemical properties and pH gradient to incorporate innovative polymeric drug delivery vehicles in anticancer applications. A myriad of research fields has introduced nanocellulose as an intriguing candidate for anticancer drug excipient and carrier in modern cancer therapy. Albeit, innovative nanocellulose-based drug carrier systems will be complicated for their commercial use in pharmacies. Of this, it is required to understand the preparation, properties, and potential drug conjugation of nanocellulose to improve its interactions with human tissues.

Filamentous supramolecular peptide–drug conjugates as highly efficient drug delivery vehicles

2014 ◽  
Vol 50 (37) ◽  
pp. 4827-4830 ◽  
Author(s):  
Miao Yang ◽  
Dawei Xu ◽  
Linhai Jiang ◽  
Lin Zhang ◽  
Derek Dustin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Efficacy ◽  
Cancer Drug ◽  
Peptide Drug ◽  
Drug Delivery Vehicles ◽  
Drug Conjugates ◽  
Anti Cancer ◽  
Delivery Vehicles ◽  
Peptide Drug Conjugates

We report here a facile approach to prepare filamentous supramolecular peptide–drug conjugates with precise drug/carrier stoichiometry, nearly 100% loading efficiency and exceptional anti-cancer drug efficacy for chemotherapy.

Tailored Viscosity Reduction in Aqueous Hydroxypropylcellulose Solutions

1995 ◽  
Vol 394 ◽  
Author(s):  
Victoria A. Prevysh ◽  
Richard J. Spontak ◽  
Saad A. Khan
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Pharmaceutical Industry ◽  
Viscosity Reduction ◽  
Self Organization ◽  
Solution Viscosity ◽  
Dynamic Rheology ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

AbstractPolysaccharides, including cellulosic derivatives such as hydroxypropylcellulose (HPC), are used extensively in the pharmaceutical industry due to their biocompatibility and self-organization properties. While drug delivery vehicles employing, for instance, aqueous polysaccharide gels are desirable, production of such gels can be hindered by tremendously high solution viscosity. In this work, we describe a novel means by which to reduce the viscosity and enhance the solubility of aqueous HPC. Here, the efficacy of several additives which promote HPC viscosity reduction through molecular salting-in is examined by dynamic rheology and light/electron microscopy.

Phosphorylcholine-Based pH-Responsive Diblock Copolymer Micelles as Drug Delivery Vehicles:  Light Scattering, Electron Microscopy, and Fluorescence Experiments

2006 ◽  
Vol 7 (3) ◽  
pp. 817-828 ◽  
Author(s):  
Cristiano Giacomelli ◽  
Lucile Le Men ◽  
Redouane Borsali ◽  
Joséphine Lai-Kee-Him ◽  
Alain Brisson ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Light Scattering ◽  
Diblock Copolymer ◽  
Ph Responsive ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Copolymer Micelles

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

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