Background:
The development of multicomponent reactions (MCRs) in the presence of
task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as
catalysts, is a new approach that meet with the requirements of sustainable chemistry.
In recent years, the use of ionic liquids as a green media for organic synthesis has become a chief
study area. This is due to their unique properties such as non-volatility, non-flammability, chemical
and thermal stability, immiscibility with both organic compounds and water and recyclability. Ionic
liquids are used as environmentally friendly solvents instead of hazardous organic solvents.
Objective:
We report the condensation reaction between α-oximinoketone and dialkyl acetylene
dicarboxylate in the presence of triphenylphosphine to afford substituted pyrroles under ionic liquid
conditions in good yields.
Result:
Densely functionalized pyrroles was easily prepared from reaction of α-oximinoketones,
dialkyl acetylene dicarboxylate in the presence of triphenylphosphine in a quantitative yield under
ionic liquid conditions at room temperature.
Conclusion:
In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the
selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous
organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time,
having easily available-recyclable ionic liquids, and good to high yields are advantages of present
method.
Colloidal nickel/gallium nanoalloys obtained from organometallic precursors in conventional organic solvents and in ionic liquids: noble-metal-free alkyne semihydrogenation catalysts