Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems

Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules.

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Colloidal stability of nano-sized particles in the peritoneal fluid: Towards optimizing drug delivery systems for intraperitoneal therapy

Acta Biomaterialia ◽

10.1016/j.actbio.2014.03.012 ◽

2014 ◽

Vol 10 (7) ◽

pp. 2965-2975 ◽

Cited By ~ 40

Author(s):

George R. Dakwar ◽

Elisa Zagato ◽

Joris Delanghe ◽

Sabrina Hobel ◽

Achim Aigner ◽

...

Keyword(s):

Drug Delivery ◽

Peritoneal Fluid ◽

Drug Delivery Systems ◽

Colloidal Stability ◽

Delivery Systems ◽

Intraperitoneal Therapy

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Thermoresponsive Chitosan-Grafted-Poly(N-Vinylcaprolactam) Microgels Via Ionotropic Gelation for Oncological Applications

Pharmaceutics ◽

10.3390/pharmaceutics13101654 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1654

Author(s):

Lorenzo Marsili ◽

Michele Dal Bo ◽

Federico Berti ◽

Giuseppe Toffoli

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Colloidal Stability ◽

Delivery Systems ◽

Clinical Applications ◽

Inorganic Nanoparticles ◽

Gel Structure ◽

Ionotropic Gelation ◽

Deformable Particles ◽

Average Size

Microgels can be considered soft, porous and deformable particles with an internal gel structure swollen by a solvent and an average size between 100 and 1000 nm. Due to their biocompatibility, colloidal stability, their unique dynamicity and the permeability of their architecture, they are emerging as important candidates for drug delivery systems, sensing and biocatalysis. In clinical applications, the research on responsive microgels is aimed at the development of “smart” delivery systems that undergo a critical change in conformation and size in reaction to a change in environmental conditions (temperature, magnetic fields, pH, concentration gradient). Recent achievements in biodegradable polymer fabrication have resulted in new appealing strategies, including the combination of synthetic and natural-origin polymers with inorganic nanoparticles, as well as the possibility of controlling drug release remotely. In this review, we provide a literature review on the use of dual and multi-responsive chitosan-grafted-poly-(N-vinylcaprolactam) (CP) microgels in drug delivery and oncological applications.

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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