Electrochemical modulation of plasma fibronectin surface conformation enables filament formation and control of endothelial cell–surface interactions

RSC Advances ◽  
2014 ◽  
Vol 4 (88) ◽  
pp. 47769-47780 ◽  
Author(s):  
Mahdi Dargahi ◽  
Valentin Nelea ◽  
Aisha Mousa ◽  
Sasha Omanovic ◽  
Mari T. Kaartinen
Keyword(s):  
Endothelial Cell ◽  
Conformational Changes ◽  
Gold Surface ◽  
Surface Interactions ◽  
Charged Surface ◽  
Filament Formation ◽  
Endothelial Cell Surface ◽  
Cell Surface Interactions ◽  
And Control ◽  
Surface Conformation

Electrochemical modulation of a gold surface charge induces conformational changes in fibronectin when immobilized on the surface. A negatively-charged surface yields an open and filamentous fibronectin which significantly improves endothelial cell adhesion.

scholarly journals Surface modification of hydrophobic polymers for improvement of endothelial cell-surface interactions

1992 ◽  
Vol 11 (1-4) ◽  
pp. 157-162 ◽  
Author(s):  
A. Dekker ◽  
K. Reitsma ◽  
T. Beugeling ◽  
A. Bantjes ◽  
J. Feijen ◽  
...  
Keyword(s):  
Surface Modification ◽  
Endothelial Cell ◽  
Cell Surface ◽  
Surface Interactions ◽  
Endothelial Cell Surface ◽  
Hydrophobic Polymers ◽  
Cell Surface Interactions

High Levels of Circulating Thrombomodulin in Human Foetuses and Children

1999 ◽  
Vol 81 (06) ◽  
pp. 906-909 ◽  
Author(s):  
Marie-Hélène Aurousseau ◽  
Danielle Gozin ◽  
Fernand Daffos ◽  
Armando D’Angelo ◽  
François Forestier ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Protein C ◽  
Endothelial Cell Surface ◽  
A Value ◽  
Median Level ◽  
Group A ◽  
Anticoagulant Function ◽  
Cell Surface Proteoglycan ◽  
Human Foetuses

SummaryThrombomodulin (TM) is an endothelial cell surface proteoglycan with anticoagulant functions, also implicated in cell proliferation, cell-cell adhesion and differentiation. In this study we determined circulating plasma TM (pTM) levels in human foetuses at different stages of pregnancy, at birth and in childhood. TM levels increased with gestational age, the median level reaching a peak of approximately 165 ng/ml between the 23rd and 26th week, thereafter decreasing gradually, reaching a value of 108 ng/ml at birth. pTM continues to decrease progressively during childhood, reaching in the 5-15 years group a median of 56 ng/ml which approaches the adult value. The pTM peak was statistically significant and represents a specific foetal phenomenon as it was independent of the corresponding maternal values. As a whole, the pTM pattern during foetal maturation appears totally different from that of protein C, prothrombin and other coagulation activators and inhibitors and thus, TM may play in the foetus another role in addition to its well-known anticoagulant function.

scholarly journals Endogenous hyaluronate-cell surface interactions in 3T3 and simian virus-transformed 3T3 cells.

1984 ◽  
Vol 259 (15) ◽  
pp. 9440-9446
Author(s):  
R L Goldberg ◽  
J D Seidman ◽  
G Chi-Rosso ◽  
B P Toole
Keyword(s):  
Cell Surface ◽  
Surface Interactions ◽  
Simian Virus ◽  
3T3 Cells ◽  
Cell Surface Interactions

Stimuli-responsive interfaces and systems for the control of protein–surface and cell–surface interactions

Biomaterials ◽  
2009 ◽  
Vol 30 (9) ◽  
pp. 1827-1850 ◽  
Author(s):  
Martin A. Cole ◽  
Nicolas H. Voelcker ◽  
Helmut Thissen ◽  
Hans J. Griesser
Keyword(s):  
Cell Surface ◽  
Surface Interactions ◽  
Stimuli Responsive ◽  
Protein Surface ◽  
Cell Surface Interactions
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