Structure of a TLR4-interacting SPA4 peptide

We have recently identified a toll-like receptor (TLR4)-interacting SPA4 peptide encoding amino acids: GDFRYSDGTPVNYTNWYRGE, a shorter region of human surfactant protein-A (SP-A).

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Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

The Journal of Immunology ◽

10.4049/jimmunol.168.12.5989 ◽

2002 ◽

Vol 168 (12) ◽

pp. 5989-5992 ◽

Cited By ~ 219

Author(s):

Loïc Guillot ◽

Viviane Balloy ◽

Francis X. McCormack ◽

Douglas T. Golenbock ◽

Michel Chignard ◽

...

Keyword(s):

Lung Surfactant ◽

Protein A ◽

Surfactant Protein ◽

Cutting Edge ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Immunostimulatory Activity ◽

Toll Like Receptor 4 ◽

Lung Surfactant Protein

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Direct Binding of Toll-Like Receptor 2 to Zymosan, and Zymosan-Induced NF-κB Activation and TNF-α Secretion Are Down-Regulated by Lung Collectin Surfactant Protein A

The Journal of Immunology ◽

10.4049/jimmunol.171.1.417 ◽

2003 ◽

Vol 171 (1) ◽

pp. 417-425 ◽

Cited By ~ 219

Author(s):

Morihito Sato ◽

Hitomi Sano ◽

Daisuke Iwaki ◽

Kazumi Kudo ◽

Masanori Konishi ◽

...

Keyword(s):

Protein A ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Tnf Α ◽

Direct Binding ◽

Toll Like Receptor 2

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Interaction between Surfactant Protein‐A and Toll‐like Receptor‐4 in Lung

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.672.12 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Shanjana Awasthi ◽

Kevin Brown ◽

Roman Wolf ◽

Gary White

Keyword(s):

Protein A ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Toll Like Receptor 4

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Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-α Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2

Journal of Biological Chemistry ◽

10.1074/jbc.m106671200 ◽

2001 ◽

Vol 277 (9) ◽

pp. 6830-6837 ◽

Cited By ~ 127

Author(s):

Seiji Murakami ◽

Daisuke Iwaki ◽

Hiroaki Mitsuzawa ◽

Hitomi Sano ◽

Hiroki Takahashi ◽

...

Keyword(s):

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Protein A ◽

Direct Interaction ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Toll Like Receptor 2 ◽

Factor Α ◽

Necrosis Factor

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Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells

Cellular Immunology ◽

10.1016/j.cellimm.2011.02.009 ◽

2011 ◽

Vol 268 (2) ◽

pp. 87-96 ◽

Cited By ~ 14

Author(s):

Shanjana Awasthi ◽

Rakhesh Madhusoodhanan ◽

Roman Wolf

Keyword(s):

Dendritic Cell ◽

Protein A ◽

Surfactant Protein ◽

Precursor Cells ◽

Surfactant Protein A ◽

Immune Functions ◽

Toll Like Receptor ◽

Cell Precursor ◽

Toll Like Receptor 4 ◽

Dendritic Cell Precursor

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Toll-like Receptor 2 (TLR2), Transforming Growth Factor-β, Hyaluronan (HA), and Receptor for HA-mediated Motility (RHAMM) Are Required for Surfactant Protein A-stimulated Macrophage Chemotaxis

Journal of Biological Chemistry ◽

10.1074/jbc.m112.360982 ◽

2012 ◽

Vol 287 (44) ◽

pp. 37406-37419 ◽

Cited By ~ 30

Author(s):

Joseph P. Foley ◽

David Lam ◽

Hongmei Jiang ◽

Jie Liao ◽

Naeun Cheong ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Protein A ◽

Transforming Growth Factor Β ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Macrophage Chemotaxis ◽

Toll Like Receptor 2

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Changes in blood monocyte Toll-like receptor and serum surfactant protein A reveal a pathophysiological mechanism for community-acquired pneumonia in patients with type 2 diabetes

Internal Medicine Journal ◽

10.1111/imj.12978 ◽

2016 ◽

Vol 46 (2) ◽

pp. 213-219 ◽

Cited By ~ 1

Author(s):

Y. Que ◽

X. Shen

Keyword(s):

Type 2 Diabetes ◽

Protein A ◽

Surfactant Protein ◽

Community Acquired Pneumonia ◽

Surfactant Protein A ◽

Blood Monocyte ◽

Pathophysiological Mechanism ◽

Toll Like Receptor

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A Toll-Like Receptor-4-Interacting Surfactant Protein-A-Derived Peptide Suppresses Tumor Necrosis Factor-α Release from Mouse JAWS II Dendritic Cells

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.173765 ◽

2010 ◽

Vol 336 (3) ◽

pp. 672-681 ◽

Cited By ~ 15

Author(s):

Shanjana Awasthi ◽

Kevin Brown ◽

Catherine King ◽

Vibhudutta Awasthi ◽

Rajkumar Bondugula

Keyword(s):

Dendritic Cells ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Protein A ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

Factor Α ◽

Necrosis Factor

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Surfactant protein A amino acids Glu195 and Arg197 are essential for receptor binding, phospholipid aggregation, regulation of secretion, and the facilitated uptake of phospholipid by type II cells.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)43952-x ◽

1994 ◽

Vol 269 (47) ◽

pp. 29801-29807 ◽

Cited By ~ 1

Author(s):

F X McCormack ◽

Y Kuroki ◽

J J Stewart ◽

R J Mason ◽

D R Voelker

Keyword(s):

Amino Acids ◽

Receptor Binding ◽

Protein A ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Type Ii Cells ◽

Type Ii ◽

Regulation Of Secretion

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Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB

Cytokine ◽

10.1016/j.cyto.2011.03.005 ◽

2011 ◽

Vol 55 (1) ◽

pp. 40-47 ◽

Cited By ~ 23

Author(s):

Tsu-Tuan Wu ◽

Ta-Liang Chen ◽

Wun-Sing Loon ◽

Yu-Ting Tai ◽

Yih-Giun Cherng ◽

...

Keyword(s):

Protein A ◽

A549 Cells ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Toll Like Receptor ◽

Alveolar Epithelial ◽

Sequential Activation ◽

Toll Like Receptor 2

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