Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB

Cytokine ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Tsu-Tuan Wu ◽  
Ta-Liang Chen ◽  
Wun-Sing Loon ◽  
Yu-Ting Tai ◽  
Yih-Giun Cherng ◽  
...  
Keyword(s):  
Protein A ◽  
A549 Cells ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Alveolar Epithelial ◽  
Sequential Activation ◽  
Toll Like Receptor 2

scholarly journals Structure of a TLR4-interacting SPA4 peptide

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27431-27438 ◽  
Author(s):  
Shanjana Awasthi ◽  
Asokan Anbanandam ◽  
Karla K. Rodgers
Keyword(s):  
Amino Acids ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Toll Like Receptor

We have recently identified a toll-like receptor (TLR4)-interacting SPA4 peptide encoding amino acids: GDFRYSDGTPVNYTNWYRGE, a shorter region of human surfactant protein-A (SP-A).

scholarly journals Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 ◽  
Vol 168 (12) ◽  
pp. 5989-5992 ◽  
Author(s):  
Loïc Guillot ◽  
Viviane Balloy ◽  
Francis X. McCormack ◽  
Douglas T. Golenbock ◽  
Michel Chignard ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Immunostimulatory Activity ◽  
Toll Like Receptor 4 ◽  
Lung Surfactant Protein

scholarly journals Recent progress on surfactant protein A: cellular function in lung and kidney disease development

2020 ◽  
Vol 319 (2) ◽  
pp. C316-C320
Author(s):  
Skylar D. King ◽  
Shi-You Chen
Keyword(s):  
Kidney Diseases ◽  
Protein A ◽  
Active Surface ◽  
Surfactant Protein ◽  
Alveolar Epithelial Cells ◽  
Surfactant Protein A ◽  
Alveolar Epithelial ◽  
Host Immune Responses ◽  
Alveolar Collapse ◽  
Lung And Kidney

Pulmonary surfactant is a heterogeneous active surface complex made up of lipids and proteins. The major glycoprotein in surfactant is surfactant protein A (SP-A), which is released into the alveolar lumen from cytoplasmic lamellar bodies in type II alveolar epithelial cells. SP-A is involved in phospholipid absorption. SP-A together with other surfactant proteins and phospholipids prevent alveolar collapse during respiration by decreasing the surface tension of the air-liquid interface. Additionally, SP-A interacts with pathogens to prevent their propagation and regulate host immune responses. Studies in human and animal models have shown that deficiencies or mutations in surfactant components result in various lung or kidney pathologies, suggesting a role for SP-A in the development of lung and kidney diseases. In this mini-review, we discuss the current understanding of SP-A functions, recent findings of its dysfunction in specific lung and kidney pathologies, and how SP-A has been used as a biomarker to detect the outcome of lung diseases.

scholarly journals Interaction between Surfactant Protein‐A and Toll‐like Receptor‐4 in Lung

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Shanjana Awasthi ◽  
Kevin Brown ◽  
Roman Wolf ◽  
Gary White
Keyword(s):  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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