Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis
The dehydratase domain BorDH3 is assayed with a synthetic surrogate of the predicted tetraketide substrate and shown to be E-selective. Detailed NMR spectroscopic analysis of pre-borrelidin assigns the timing of the E-5 Z-isomerization to the very final steps of borrelidin biosynthesis.
1972 ◽
Vol 180
(1059)
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pp. 147-165
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1990 ◽
Vol 55
(12)
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pp. 2874-2879
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Keyword(s):
Keyword(s):
2015 ◽
Vol 11
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pp. 1163-1174
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Keyword(s):
Keyword(s):