pH-controlled release of substrates from mesoporous SiO2 nanoparticles gated by metal ion-dependent DNAzymes

2014 ◽  
Vol 2 (28) ◽  
pp. 4449-4455 ◽  
Author(s):  
Zhanxia Zhang ◽  
Fuan Wang ◽  
Dora Balogh ◽  
Itamar Willner
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Metal Ion ◽  
Mesoporous Silica Nanoparticles ◽  
Sio2 Nanoparticles ◽  
Mesoporous Sio2 ◽  
Ph Controlled ◽  
Programmed Release

pH-programmed release of fluorescent substrates from mesoporous silica nanoparticles is stimulated by Mg2+- or UO22+-dependent DNAzymes unlocking the pores.

scholarly journals Are Biogenic and Pyrogenic Mesoporous SiO2 Nanoparticles Safe for Normal Cells?

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1427
Author(s):  
Katarzyna Solarska-Ściuk ◽  
Kinga Adach ◽  
Sylwia Cyboran-Mikołajczyk ◽  
Dorota Bonarska-Kujawa ◽  
Agnieszka Rusak ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biological Effects ◽  
Mesoporous Silica Nanoparticles ◽  
Volume Ratio ◽  
Sio2 Nanoparticles ◽  
Amorphous Structure ◽  
Intracellular Ros ◽  
Materials Used ◽  
The Impact

Silicon dioxide, in the form of nanoparticles, possesses unique physicochemical properties (size, shape, and a large surface to volume ratio). Therefore, it is one of the most promising materials used in biomedicine. In this paper, we compare the biological effects of both mesoporous silica nanoparticles extracted from Urtica dioica L. and pyrogenic material. Both SEM and TEM investigations confirmed the size range of tested nanoparticles was between 6 and 20 nanometers and their amorphous structure. The cytotoxic activity of the compounds and intracellular ROS were determined in relation to cells HMEC-1 and erythrocytes. The cytotoxic effects of SiO2 NPs were determined after exposure to different concentrations and three periods of incubation. The same effects for endothelial cells were tested under the same range of concentrations but after 2 and 24 h of exposure to erythrocytes. The cell viability was measured using spectrophotometric and fluorimetric assays, and the impact of the nanoparticles on the level of intracellular ROS. The obtained results indicated that bioSiO2 NPs, present higher toxicity than pyrogenic NPs and have a higher influence on ROS production. Mesoporous silica nanoparticles show good hemocompatibility but after a 24 h incubation of erythrocytes with silica, the increase in hemolysis process, the decrease in osmotic resistance of red blood cells, and shape of erythrocytes changed were observed.

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release

2015 ◽  
Vol 26 (10) ◽  
pp. 1203-1208 ◽  
Author(s):  
Yu-Jie Chang ◽  
Xi-Zhen Liu ◽  
Qing Zhao ◽  
Xiao-Hai Yang ◽  
Ke-Min Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

2018 ◽  
Vol 340 ◽  
pp. 2-8 ◽  
Author(s):  
Juan L. Paris ◽  
Christophoros Mannaris ◽  
M. Victoria Cabañas ◽  
Robert Carlisle ◽  
Miguel Manzano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Drug

scholarly journals Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes

2016 ◽  
Vol 22 (39) ◽  
pp. 13935-13945 ◽  
Author(s):  
Sameh El Sayed ◽  
Michele Milani ◽  
Chiara Milanese ◽  
Maurizio Licchelli ◽  
Ramón Martínez-Máñez ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles
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