Synthesis and in vitro evaluation of charge reversal photoresponsive quinoline tethered mesoporous silica for targeted drug delivery

2014 ◽  
Vol 2 (45) ◽  
pp. 7971-7977 ◽  
Author(s):  
S. Karthik ◽  
Avijit Jana ◽  
Biswajit Saha ◽  
B. Krishna Kalyani ◽  
Sudip Kumar Ghosh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Charge Reversal ◽  
In Vitro Evaluation ◽  
Targeted Drug

We developed excellent charge reversal photoresponsive nanoparticles for targeted delivery of the anticancer drug chlorambucil.

scholarly journals SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation

2016 ◽  
Vol 10 (7) ◽  
pp. 1133-1145 ◽  
Author(s):  
Johannes M. Ludwig ◽  
Yongkang Gai ◽  
Lingyi Sun ◽  
Guangya Xiang ◽  
Dexing Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
In Vitro Evaluation ◽  
Drug Eluting ◽  
Delivery Platform ◽  
Targeted Drug

Corrigendum to: Establishment and In Vitro Evaluation of Porous Ion-Responsive Targeted Drug Delivery System. Protein & Peptide Letters, volume 27(11), (2020).

2021 ◽  
Vol 28 (3) ◽  
pp. 359-359
Author(s):  
Hongfei Liu ◽  
Jie Zhu ◽  
Pengyue Bao ◽  
Yueping Ding ◽  
Jiapeng Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Electronic Version ◽  
In Vitro Evaluation ◽  
Corrected Version ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The authors are regretful for submitting and approving the publication of incorrect Figure 4 in this article. Below is the corrected version along with the revised caption. The electronic version of the article has already been corrected.

Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system

2010 ◽  
Vol 16 (4) ◽  
pp. 331-342 ◽  
Author(s):  
Ghassan Z. Abdullah ◽  
Muthanna F. Abdulkarim ◽  
Mallikarjun Chitneni ◽  
Ahmed F. Mutee ◽  
Omar Z. Ameer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
In Vitro Evaluation ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

scholarly journals Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models

2021 ◽  
Vol 9 ◽  
Author(s):  
Sayoni Maitra Roy ◽  
Vrinda Garg ◽  
Sourav Barman ◽  
Chitrita Ghosh ◽  
Amit Ranjan Maity ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Drug Delivery ◽  
Mathematical Models ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Model System ◽  
Drug Candidates ◽  
Targeted Drug

Numerous strategies have been developed to treat cancer conventionally. Most importantly, chemotherapy shows its huge promise as a better treatment modality over others. Nonetheless, the very complex behavior of the tumor microenvironment frequently impedes successful drug delivery to the tumor sites that further demands very urgent and effective distribution mechanisms of anticancer drugs specifically to the tumor sites. Hence, targeted drug delivery to tumor sites has become a major challenge to the scientific community for cancer therapy by assuring drug effects to selective tumor tissue and overcoming undesired toxic side effects to the normal tissues. The application of nanotechnology to the drug delivery system pays heed to the design of nanomedicine for specific cell distribution. Aiming to limit the use of traditional strategies, the adequacy of drug-loaded nanocarriers (i.e., nanomedicine) proves worthwhile. After systemic blood circulation, a typical nanomedicine follows three levels of disposition to tumor cells in order to exhibit efficient pharmacological effects induced by the drug candidates residing within it. As a result, nanomedicine propounds the assurance towards the improved bioavailability of anticancer drug candidates, increased dose responses, and enhanced targeted efficiency towards delivery and distribution of effective therapeutic concentration, limiting toxic concentration. These aspects emanate the proficiency of drug delivery mechanisms. Understanding the potential tumor targeting barriers and limiting conditions for nanomedicine extravasation, tumor penetration, and final accumulation of the anticancer drug to tumor mass, experiments with in vivo animal models for nanomedicine screening are a key step before it reaches clinical translation. Although the study with animals is undoubtedly valuable, it has many associated ethical issues. Moreover, individual experiments are very expensive and take a longer time to conclude. To overcome these issues, nowadays, multicellular tumor spheroids are considered a promising in vitro model system that proposes better replication of in vivo tumor properties for the future development of new therapeutics. In this review, we will discuss how tumor spheroids could be used as an in vitro model system to screen nanomedicine used in targeted drug delivery, aiming for better therapeutic benefits. In addition, the recent proliferation of mathematical modeling approaches gives profound insight into the underlying physical principles and produces quantitative predictions. The hierarchical tumor structure is already well decorous to be treated mathematically. To study targeted drug delivery, mathematical modeling of tumor architecture, its growth, and the concentration gradient of oxygen are the points of prime focus. Not only are the quantitative models circumscribed to the spheroid, but also the role of modeling for the nanoparticle is equally inevitable. Abundant mathematical models have been set in motion for more elaborative and meticulous designing of nanomedicine, addressing the question regarding the objective of nanoparticle delivery to increase the concentration and the augmentative exposure of the therapeutic drug molecule to the core. Thus, to diffuse the dichotomy among the chemistry involved, biological data, and the underlying physics, the mathematical models play an indispensable role in assisting the experimentalist with further evaluation by providing the admissible quantitative approach that can be validated. This review will provide an overview of the targeted drug delivery mechanism for spheroid, using nanomedicine as an advantageous tool.

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