Triple helix conformation-specific blinking of Cy3 in DNA

Beta-glucans comprise a group of polysaccharides of natural origin found in bacteria, algae, and plants, e.g., cereal seeds, as well as microfungi and macrofungi (mushrooms), which are characterized by diverse structures and functions. They are known for their metabolic and immunomodulatory properties, including anticancer, antibacterial, and antiviral. Recent reports suggest a potential of beta-glucans in the prevention and treatment of COVID-19. In contrast to β-glucans from other sources, β-glucans from mushrooms are characterized by β-1,3-glucans with short β-1,6-side chains. This structure is recognized by receptors located on the surface of immune cells; thus, mushroom β-glucans have specific immunomodulatory properties and gained BRM (biological response modifier) status. Moreover, mushroom beta-glucans also owe their properties to the formation of triple helix conformation, which is one of the key factors influencing the bioactivity of mushroom beta-glucans. This review summarizes the latest findings on biological and health-promoting potential of mushroom beta-glucans for the treatment of civilization and viral diseases, with particular emphasis on COVID-19.

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Triple helix conformation of β-d-glucan from Ganoderma lucidum and effect of molecular weight on its immunostimulatory activity

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2018.03.054 ◽

2018 ◽

Vol 114 ◽

pp. 1064-1070 ◽

Cited By ~ 14

Author(s):

Yanfang Liu ◽

Qingjiu Tang ◽

Jingsong Zhang ◽

Yongmei Xia ◽

Yan Yang ◽

...

Keyword(s):

Molecular Weight ◽

Ganoderma Lucidum ◽

Triple Helix ◽

Immunostimulatory Activity ◽

Helix Conformation

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Observation of a Partially Opened Triple-helix Conformation in 1→3-β-Glucan by Fluorescence Resonance Energy Transfer Spectroscopy

Journal of Biological Chemistry ◽

10.1074/jbc.275.16.11874 ◽

2000 ◽

Vol 275 (16) ◽

pp. 11874-11879 ◽

Cited By ~ 65

Author(s):

Shih-Houng Young ◽

Wen-Ji Dong ◽

Robert R. Jacobs

Keyword(s):

Energy Transfer ◽

Fluorescence Resonance Energy Transfer ◽

Triple Helix ◽

Resonance Energy Transfer ◽

Resonance Energy ◽

Helix Conformation ◽

Fluorescence Resonance

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Characterization of the effects of the disease causing mutations on the triple helix conformation using recombinant collagen fragments from E coli.

The FASEB Journal ◽

10.1096/fasebj.20.4.a517 ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Ke Xu ◽

Iwona Nowak ◽

Yujia Xu

Keyword(s):

Triple Helix ◽

E Coli ◽

Helix Conformation

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“Triple Helix” in Russia’s Innovation System

Voprosy Ekonomiki ◽

10.32609/0042-8736-2007-12-123-135 ◽

2007 ◽

pp. 123-135 ◽

Cited By ~ 5

Author(s):

I. Dezhina ◽

V. Kiseleva

Keyword(s):

Triple Helix ◽

Government Regulation ◽

Innovation System ◽

Innovation Systems ◽

Modern Theory

The article analyzes modern theory that explains the specificity of relationships among government, science and business in innovation systems - the "triple helix" concept. Factors that determine the appearance of new theory are systematized. The peculiarities of formation of "triple helix" in Russia are described, including the development of science, business and the system of government regulation in innovation sphere. The conclusion is made that currently in Russia only double linkages are formed.

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