Palladium–N-heterocyclic carbene (NHC)-catalyzed synthesis of 2-ynamides via oxidative aminocarbonylation of alkynes with amines

2015 ◽  
Vol 5 (10) ◽  
pp. 4750-4754 ◽  
Author(s):  
Chunyan Zhang ◽  
Jianhua Liu ◽  
Chungu Xia
Keyword(s):  
Reaction Conditions ◽  
Efficient Approach

Palladium–NHC compounds catalyzing the oxidative aminocarbonylation of alkynes and amines have been developed with oxygen as the benign oxidant under mild reaction conditions, which led to an efficient approach toward the formation a series of alphatic and aromatic 2-ynamides with high atom efficiency.

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

Synthesis of the Novel Thienopyrimidine-Based S-Glycoside Analogues via Nucleophilic Addition/Cyclization/Glycosylation Reactions

2013 ◽  
Vol 781-784 ◽  
pp. 999-1002
Author(s):  
Qiu Hong Dai ◽  
Kun Zou ◽  
Ming Guo Liu ◽  
Lin Luo ◽  
Nian Yu Huang
Keyword(s):  
Elemental Analysis ◽  
Nucleophilic Addition ◽  
The Novel ◽  
Reaction Conditions ◽  
Biological Screening ◽  
Structural Motifs ◽  
Efficient Approach

The title compounds thienopyrimidine-basedS-glycoside analogues were synthesized through the nucleophilic addition/cyclization/glycosylation reactions in good yields from easily accessible starting materials under mild reaction conditions. All of compounds were characterized by NMR, MS, IR and elemental analysis. The efficient approach allowed the facial synthesis of small libraries of thienopyrimidine-basedS-glycoside analogues with different structural motifs for biological screening.

scholarly journals Breaking Molecular Symmetry through Biocatalytic Reactions to Gain Access to Valuable Chiral Synthons

Symmetry ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1454
Author(s):  
Angela Patti ◽  
Claudia Sanfilippo
Keyword(s):  
Bioactive Compounds ◽  
Continuous Flow ◽  
Molecular Diversity ◽  
Molecular Symmetry ◽  
Flow Conditions ◽  
Reaction Conditions ◽  
Whole Cells ◽  
Efficient Approach ◽  
Substrate Tolerance ◽  
Gain Access

In this review the recent reports of biocatalytic reactions applied to the desymmetrization of meso-compounds or symmetric prochiral molecules are summarized. The survey of literature from 2015 up to date reveals that lipases are still the most used enzymes for this goal, due to their large substrate tolerance, stability in different reaction conditions and commercial availability. However, a growing interest is focused on the use of other purified enzymes or microbial whole cells to expand the portfolio of exploitable reactions and the molecular diversity of substrates to be transformed. Biocatalyzed desymmetrization is nowadays recognized as a reliable and efficient approach for the preparation of pharmaceuticals or natural bioactive compounds and many processes have been scaled up for multigram preparative purposes, also in continuous-flow conditions.

scholarly journals Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles

2016 ◽  
Vol 52 (37) ◽  
pp. 6324-6327 ◽  
Author(s):  
Ming Chen ◽  
Ning Sun ◽  
Haoyi Chen ◽  
Yuanhong Liu
Keyword(s):  
Gold Catalysis ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Nitrene Transfer

The gold-catalyzed regioselective [3+2] cycloaddition of ynamides with 1,4,2-dioxazoles offers an efficient approach to functionalized oxazoles under mild reaction conditions.

One-Pot Synthesis of Functionalised 4-Spiro-1,4-Dihydropyridines Via [1+2+1+2]-Cyclisation

2017 ◽  
Vol 41 (9) ◽  
pp. 513-516 ◽  
Author(s):  
Pan Zhou ◽  
Biao Hu ◽  
Lingling Lu ◽  
Rong Huang ◽  
Fuchao Yu
Keyword(s):  
Acetic Acid ◽  
Ammonium Acetate ◽  
Water Solution ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Approach ◽  
H Nmr ◽  
Three Component Reaction ◽  
C Nmr ◽  
Operational Simplicity

A simple and efficient approach for the synthesis of 4-spiro-1,4-DHP derivatives has been developed, involving one-pot three-component reaction of isatins, N,N-dimethylenaminones with ammonium acetate in EtOH–water solution promoted by acetic acid. Compared with the previous [1+2+3]-cyclisation method, this [1+2+1+2]-cyclisation procedure has advantages as it is more environmentally friendly, has easier operational simplicity, and requires milder reaction conditions. Moreover, these novel compounds have been obtained in moderate to good yields and their structures have been confirmed by 1H NMR, 13C NMR and IR and HRMS spectroscopy.

Palladium-Catalyzed Cross-Coupling Reactions of 4-Tosyl­oxyquinazolines with Indoles: An Efficient Approach to 4-(1H-Indol-1-yl)quinazolines

Synthesis ◽  
2020 ◽  
Vol 53 (02) ◽  
pp. 383-390 ◽  
Author(s):  
Yiyuan Peng ◽  
Xinglin Ye ◽  
Jian Huang ◽  
Zhihong Deng ◽  
Jianjun Yuan
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Indole Derivatives ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed

In this paper, exploration of our continuous interests on late-stage derivation of quinozaline core is described. A wide array of 4-(1H-indol-1-yl)quinazolines were obtained in good to excellent yields through palladium-catalyzed cross-coupling of 4-tosyloxyquinazolines with indole derivatives under mild reaction conditions.

Pseudo five-component process for the synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives using ZnAl2O4 nanoparticles in aqueous media

RSC Advances ◽  
2014 ◽  
Vol 4 (86) ◽  
pp. 46106-46113 ◽  
Author(s):  
Javad Safaei-Ghomi ◽  
Bahareh Khojastehbakht-Koopaei ◽  
Hossein Shahbazi-Alavi
Keyword(s):  
Aqueous Media ◽  
Reaction Conditions ◽  
One Pot ◽  
Component Process ◽  
Efficient Approach

In the present paper, we developed a straightforward and efficient approach to synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives by a simple one pot pseudo five component reactions using ZnAl2O4 nanoparticles as catalyst under benign reaction conditions.

Pd(NHC)-catalyzed alkylsulfonylation of boronic acids: a general and efficient approach for sulfone synthesis

2017 ◽  
Vol 53 (92) ◽  
pp. 12473-12476 ◽  
Author(s):  
Haibo Zhu ◽  
Yajing Shen ◽  
Qinyue Deng ◽  
Jinjin Chen ◽  
Tao Tu
Keyword(s):  
Boronic Acids ◽  
Alkyl Halides ◽  
Reaction Conditions ◽  
Efficient Approach

The first Pd(NHC)-catalyzed direct alkylsulfonylation of boronic acids with K2S2O5 and alkyl halides has been successfully developed to afford various functional sulfones under very mild reaction conditions at low catalyst loadings.

scholarly journals A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

2017 ◽  
Vol 13 ◽  
pp. 817-824 ◽  
Author(s):  
Taofeng Shao ◽  
Zhiming Gong ◽  
Tianyi Su ◽  
Wei Hao ◽  
Chao Che
Keyword(s):  
Synthetic Approach ◽  
Reaction Conditions ◽  
Diversity Oriented Synthesis ◽  
Efficient Approach ◽  
Rapid Construction ◽  
Transformation Strategy

Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields.

scholarly journals Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives

2018 ◽  
Vol 14 ◽  
pp. 2090-2097 ◽  
Author(s):  
Jiao-Na Han ◽  
Cong Du ◽  
Xinju Zhu ◽  
Zheng-Long Wang ◽  
Yue Zhu ◽  
...  
Keyword(s):  
Catalytic System ◽  
Functional Group ◽  
Secondary Alcohols ◽  
Reaction Conditions ◽  
Biologically Relevant ◽  
Efficient Approach ◽  
Directing Group ◽  
Aryl Ethers

A cobalt-catalyzed C(sp2)–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group.

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