Tetrabutylammonium iodide-catalyzed oxidative coupling of enamides with sulfonylhydrazides: synthesis of β-keto-sulfones

2015 ◽  
Vol 13 (25) ◽  
pp. 7084-7090 ◽  
Author(s):  
Yucai Tang ◽  
Ye Zhang ◽  
Kaifeng Wang ◽  
Xiaoqing Li ◽  
Xiangsheng Xu ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Synthetic Route ◽  
Tetrabutylammonium Iodide ◽  
Sulfone Derivatives

A novel synthetic route toward pharmaceutically interesting β-keto-sulfone derivativesviaTBAI/TBHP-mediated oxidative coupling of readily prepared enamides with sulfonylhydrazides is described.

ChemInform Abstract: Tetrabutylammonium Iodide-Catalyzed Oxidative Coupling of Enamides with Sulfonylhydrazides: Synthesis of β-Keto-Sulfones.

ChemInform ◽  
2015 ◽  
Vol 46 (44) ◽  
pp. no-no
Author(s):  
Yucai Tang ◽  
Ye Zhang ◽  
Kaifeng Wang ◽  
Xiaoqing Li ◽  
Xiangsheng Xu ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Tetrabutylammonium Iodide

Vinyl Oxidative Coupling as a Synthetic Route to Catalytically Active Monovalent Chromium

2011 ◽  
Vol 133 (16) ◽  
pp. 6388-6395 ◽  
Author(s):  
Khalid Albahily ◽  
Yacoob Shaikh ◽  
Elena Sebastiao ◽  
Sandro Gambarotta ◽  
Ilia Korobkov ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Synthetic Route ◽  
Catalytically Active

Studies with plant cell cultures of Catharanthusroseus. Oxidative coupling of dibenzylbutanolides catalyzed by plant cell culture extracts

1992 ◽  
Vol 70 (7) ◽  
pp. 2115-2133 ◽  
Author(s):  
James P. Kutney ◽  
G. M. Hewitt ◽  
Terence C. Jarvis ◽  
Jan Palaty ◽  
Steven J. Rettig
Keyword(s):  
Cell Culture ◽  
Plant Cell ◽  
Cell Cultures ◽  
Oxidative Coupling ◽  
Plant Cell Culture ◽  
Plant Cell Cultures ◽  
Cancer Drug ◽  
Synthetic Route ◽  
Anti Cancer ◽  
Commercially Important

Utilizing appropriate dibenzylbutanolides, for example 7, obtained via an efficient synthetic route from readily available aldehydes, and cell-free extracts obtained from Catharanthusroseus cell cultures, it was possible to achieve enzyme-catalyzed oxidative coupling of 7 to picropodophyllotoxin analogues. Studies are presently underway to convert such compounds to intermediates employed in the synthesis of the commercially important anti-cancer drug, etoposide.

Synthesis of Carboxybenzyl-Protected 2′-Deoxynucleoside 5′-Phosphoromorpholidates

2013 ◽  
Vol 830 ◽  
pp. 139-142
Author(s):  
Shan Shan Gong ◽  
Guo Dong Liu ◽  
Qi Sun
Keyword(s):  
Oxidative Coupling ◽  
Coupling Reactions ◽  
Synthetic Route ◽  
Acid Catalyzed ◽  
Oxidative Coupling Reactions

Four deoxynucleoside 5′-phosphoromorpholidates were prepared from carboxybenzyl-protected 2′-deoxyribonucleosides. The synthetic route involved three consecutive steps including phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling reactions.

NHPI- and TBAI-Co-Catalyzed Synthesis of Allylic Esters from Toluene Derivatives and Alkenes

Synlett ◽  
2018 ◽  
Vol 29 (06) ◽  
pp. 840-844 ◽  
Author(s):  
Hongmei Deng ◽  
Xueshun Jia ◽  
Jian Li ◽  
Chengliang Li ◽  
Tao Jin ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Metal Free ◽  
Oxidative Coupling Reaction ◽  
New Strategy ◽  
Tetrabutylammonium Iodide ◽  
Allylic Esters

An N-hydroxyphthalimide (NHPI) and tetrabutylammonium iodide (TBAI) co-catalyzed oxidative coupling reaction of toluene derivatives and alkenes has been disclosed. This method can serve as a new strategy to access allylic ester using toluene derivatives as oxyacylating reagent. This metal-free protocol also features the readily available starting materials, broad substrate scope, and mild reaction conditions.

A General Convergent Strategy for the Synthesis of Tetrasubstituted Furan Fatty Acids (FuFAs)

2019 ◽  
Author(s):  
Yamin Wang ◽  
Gareth Pritchard ◽  
Marc Kimber
Keyword(s):  
Fatty Acids ◽  
Spectral Data ◽  
Synthetic Route ◽  
Furan Fatty Acids

Synthetic route for the synthesis of tetrasubstituted furan fatty acids; including experimental details, characterisation, and spectral data of all intermediates.

Palladium-Catalyzed Asymmetric Annulation Between Aryl Iodides and Racemic Epoxides Using a Chiral Norbornene Cocatalyst

2018 ◽  
Author(s):  
Guangbin Dong ◽  
Renhe Li
Keyword(s):  
Isopropyl Ester ◽  
Synthetic Route ◽  
Initial Development ◽  
Aryl Iodides ◽  
Palladium Catalyzed

Herein, we describe our initial development of an asymmetric Pd-catalyzed annulation between aryl iodides and racemic epoxides for synthesis of 2,3-dihydrobenzofurans using a chiral norbornene cocatalyst. A series of enantiopure ester-, amide- and imide-substituted norbornenes have been prepared with a reliable synthetic route. Promising enantioselectivity (42-45% ee) has been observed using the isopropyl ester-substituted norbornene (N1*) and the amide-substituted norbornene (N7*).

Sign in / Sign up

Export Citation Format

Share Document