Stimulus responsive cross-linked AIE-active polymeric nanoprobes: fabrication and biological imaging application

2015 ◽  
Vol 6 (47) ◽  
pp. 8214-8221 ◽  
Author(s):  
Qing Wan ◽  
Ke Wang ◽  
Chengbin He ◽  
Meiying Liu ◽  
Guangjian Zeng ◽  
...  
Keyword(s):  
Biological Imaging ◽  
Stimuli Responsive ◽  
Imaging Application ◽  
Stimulus Responsive

Stimuli responsive AIE-active polymeric luminescent nanoprobes have been fabricated through formation of dynamic bonds using AIE dye as the linker.

Preparation of two-photon fluorescent probe and biological imaging application in cells

2016 ◽  
Vol 14 (6) ◽  
pp. 061603-61607 ◽  
Author(s):  
Shuheng Chi Shuheng Chi ◽  
Liang Li Liang Li ◽  
and Yiqun Wu and Yiqun Wu
Keyword(s):  
Fluorescent Probe ◽  
Biological Imaging ◽  
Two Photon ◽  
Imaging Application ◽  
In Cells

Stimulus-responsive hydrogels reinforced by cellulose nanowhisker for controlled drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87422-87432 ◽  
Author(s):  
Y. Chen ◽  
W. Y. Liu ◽  
G. S. Zeng
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Carboxymethyl Chitosan ◽  
Stimuli Responsive ◽  
Release System ◽  
Cellulose Nanowhisker ◽  
Hybrid Hydrogels ◽  
System P ◽  
Stimulus Responsive ◽  
Responsive Hydrogels

Hybrid hydrogels (W–C gels), composed of PDMAEMA, cellulose nanowhisker (CNW) and carboxymethyl chitosan (CMCS), were prepared for developing a stimuli-responsive drug-release system.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

Gold nanoparticles modified by new conjugated S=C=N terminal and its biological imaging application

2017 ◽  
Vol 141 ◽  
pp. 13-20 ◽  
Author(s):  
Anran Wang ◽  
Wan Sun ◽  
Cong Wang ◽  
Min Xu ◽  
Xin Lu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biological Imaging ◽  
Imaging Application

Facile fabrication of amphiphilic AIE active glucan via formation of dynamic bonds: self assembly, stimuli responsiveness and biological imaging

2016 ◽  
Vol 4 (22) ◽  
pp. 4033-4039 ◽  
Author(s):  
Qing Wan ◽  
Meiying Liu ◽  
Dazhuang Xu ◽  
Hongye Huang ◽  
Liucheng Mao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Self Assembly ◽  
Biological Imaging ◽  
Stimuli Responsive ◽  
One Pot ◽  
Facile Fabrication

A one-pot strategy has been developed for the preparation of stimuli responsive AIE active glucan through formation of a dynamic Schiff base and a phenyl borate.

scholarly journals MMP-13 Enzyme and pH Responsive Theranostic Nanoplatform for Osteoarthritis

2020 ◽  
Author(s):  
qiumei lan ◽  
Haimen Chen ◽  
Yunfen Pang ◽  
Feng Xiong ◽  
Chong Shen ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
High Specificity ◽  
Stimuli Responsive ◽  
Precise Control ◽  
Stimulus Responsive ◽  
Precision Therapy ◽  
Acid Environment ◽  
Therapeutic Platform

Abstract Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA). However, stimulus-responsive therapeutic platform with high specificity for OA basing on the two markers has not been developed yet. We herein demonstrate a new stimuli-responsive theranostic strategy against OA based on a novel multifunctional nano-micelle which is rationally designed and yet readily synthesized. Such nanoplatform is incorporated with a motif specifically targeting on cartilage, a motif responsive to matrix metalloproteinases-13 to specifically report OA condition and biodynamics of nano-micelles, an anti-inflammatory drug (e.g., psoralidin (PSO)) from traditional Chinese medicine, and a biocompatible polymeric skeleton for sustainable drug release in response to the acidic OA condition. The high effectiveness of this targeted precision therapy is demonstrated comprehensively by both in vitro an in vivo evidences.

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