Metabolomic study of Chinese medicine Huang Qin decoction as an effective treatment for irinotecan-induced gastrointestinal toxicity

RSC Advances ◽  
2015 ◽  
Vol 5 (33) ◽  
pp. 26420-26429 ◽  
Author(s):  
Jing Wang ◽  
Hongyan Fan ◽  
Yong Wang ◽  
Xu Wang ◽  
Pei Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Effective Treatment ◽  
Gastrointestinal Toxicity ◽  
Metabolomic Study

Metabolomic study revealed Chinese medicine HQD reducing irinotecan-induced gastrointestinal toxicity by regulating glutamine, tryptophan and lipid metabolisms.

Metabolomic study on the faecal extracts of atherosclerosis mice and its application in a Traditional Chinese Medicine

2015 ◽  
Vol 1007 ◽  
pp. 140-148 ◽  
Author(s):  
Feng Tian ◽  
Lei Gu ◽  
Aiyong Si ◽  
Quanbao Yao ◽  
Xianwei Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Metabolomic Study

scholarly journals Acupuncture in Practice: Investigating Acupuncturists’ Approach to Treating Infantile Colic

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Kajsa Landgren
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Effective Treatment ◽  
Conventional Treatment ◽  
Single Point ◽  
Personal Communication ◽  
Infantile Colic ◽  
Weak Evidence ◽  
Practitioner Survey

Infantile colic is common, but no safe and effective conventional treatment exists. The use of acupuncture has increased despite weak evidence. This practitioner survey explores and discusses how infantile colic is regarded and treated in Traditional Chinese Medicine (TCM). The study is based on personal communication with 24 acupuncturists from nine countries. These acupuncturists specialize in pediatric acupuncture and represent different styles of acupuncture. Their experiences are discussed and related to relevant books and articles. Informants claimed good results when treating infants with colic. The TCM patterns commonly described by informants matched the textbooks to a great extent. The most common syndromes were “stagnation of food” and “Spleen Qi Xu.” Regarding treatment, some informants followed the teachers’ and the textbook authors’ advice on differentiated treatment according to syndrome. The points used most often were LI4, ST36, and Sifeng. Other informants treated all infants alike in one single point, LI4. The results demonstrate the diversity of TCM. The use of acupuncture for infantile colic presents an interesting option, but further research is needed in order to optimize the effects and protect infants from unnecessary or less effective treatment.

A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosis

2017 ◽  
Vol 9 (4) ◽  
pp. 586-592 ◽  
Author(s):  
Huan Wu ◽  
Dan Wang ◽  
Jin Meng ◽  
Juanjuan Wang ◽  
Fang Feng
Keyword(s):  
Chinese Medicine ◽  
Hepatic Steatosis ◽  
Therapeutic Mechanism ◽  
Metabolomic Study ◽  
Potential Biomarkers

A plasma untargeted metabolomic study of potential biomarkers which contribute to the therapeutic mechanism of ZZDHD on AHS rats.

scholarly journals In Silico Target Analysis of Treatment for COVID-19 Using Huang-Lian-Shang-Qing-Wan, a Traditional Chinese Medicine Formula

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110308
Author(s):  
Ching-Wen Huang ◽  
Hai-Anh Ha ◽  
Shih-Chang Tsai ◽  
Chi-Cheng Lu ◽  
Chao-Ying Lee ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Effective Treatment ◽  
Bioactive Compounds ◽  
In Silico ◽  
Negative Impact ◽  
The Body ◽  
Network Pharmacology ◽  
Cell Physiology ◽  
Human Lung Cells

Due to the significantly negative impact of the coronavirus (CoV) disease (COVID-19) pandemic on the health of the community and the economy, it remains urgent and necessary to develop a safe and effective treatment method for COVID-19. Huang-Lian-Shang-Qing-Wan (HLSQW) is a herbal formula of traditional Chinese medicine (TCM) that has been applied extensively for treating “wind-heat-associated” symptoms in the upper parts of the body. The objective of the present in silico study was to investigate the potential effects of HLSQW in the context of severe acute respiratory syndrome (SARS)-CoV-2 infection. We analyzed the possible interactions between bioactive compounds within HLSQW on targets that may confer antiviral activity using network pharmacology and pharmacophore-based screening. HLSQW was found to potentially target a number of pathways and the expression of various genes to regulate cell physiology and, consequently, the anti-viral effects against SARS-CoV-2. Bioactive compounds contained within HLSQW may exert combined effects to reduce the production of proinflammatory factors, which may trigger the “cytokine storm” in patients with severe COVID-19. Results from molecular modeling suggested that the bioactive HLSQW components puerarin, baicalin, and daidzin exhibit high binding affinity to the active site of 3-chymotrypsin-like cysteine protease (3CLpro) to form stable ligand-protein complexes, thereby suppressing SARS-CoV-2 replication. In addition, our results also demonstrated protective effects of the HLSQW extract against cell injury induced by the proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, against reactive oxygen species production and nuclear factor-κB activity in normal human lung cells in vitro. To conclude, HLSQW is a potential TCM remedy that warrants further study with the aim of developing an effective treatment for COVID-19 in the future.

Successful Use of Chinese Medicine and Corticosteroid for Pemphigus Erythematosus (Senear-Usher Syndrome)

1979 ◽  
Vol 07 (04) ◽  
pp. 351-355 ◽  
Author(s):  
Shigeru Arichi ◽  
Hiroko Abe ◽  
Tadato Tani
Keyword(s):  
Chinese Medicine ◽  
Effective Treatment ◽  
Usher Syndrome ◽  
Pemphigus Vulgaris ◽  
Treatment Method ◽  
Highly Effective ◽  
Pemphigus Erythematosus

Chinese medicine was used in the treatment of a patient with pemphigus vulgaris in combination with corticosteroid (bethamethasone). Results indicate that the use of Chinese medicine in combination with corticosteroid is a highly effective treatment method for pemphigus erythematosus.

Traditional Chinese Medicine as Potential Therapy for COVID-19

2020 ◽  
Vol 48 (06) ◽  
pp. 1263-1277
Author(s):  
Shuang Li ◽  
Chang Liu ◽  
Fangyue Guo ◽  
Sarah J. Taleb ◽  
Mengying Tong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Effective Treatment ◽  
National Health ◽  
Review Paper ◽  
Treatment Guidelines ◽  
Chinese People ◽  
Infected People ◽  
Global Pandemic ◽  
Novel Coronavirus

In December 2019, a novel coronavirus SARS-CoV-2, causing the disease COVID-19, spread from Wuhan throughout China and has infected people over 200 countries. Thus far, more than 3,400,000 cases and 240,000 deaths have occurred worldwide, and the coronavirus pandemic continues to grip the globe. While numbers of cases in China have been steadying, the number of infections outside China is increasing at a worrying pace. We face an urgent need to control the spread of the COVID-19 epidemic, which is currently expanding to a global pandemic. Efforts have focused on testing antiviral drugs and vaccines, but there is currently no treatment specifically approved. Traditional Chinese medicine (TCM) is grounded in empirical observations and the Chinese people use TCM to overcome these sorts of plagues many times in thousands of years of history. Currently, the Chinese National Health Commission recommended a TCM prescription of Qing-Fei-Pai-Du-Tang (QFPDT) in the latest version of the “Diagnosis and Treatment guidelines of COVID-19” which has been reported to provide reliable effects for COVID-19. While doubts about TCM still exist today, this review paper will describe the rationalities that QFPDT is likely to bring a safe and effective treatment of COVID-19.

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