Antihypertensive activity of a quinoline appended chalcone derivative and its site specific binding interaction with a relevant target carrier protein

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 65496-65513 ◽  
Author(s):  
Himank Kumar ◽  
Vinod Devaraji ◽  
Ritika Joshi ◽  
Manojkumar Jadhao ◽  
Piyush Ahirkar ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Specific Binding ◽  
Transport Protein ◽  
Clear Picture ◽  
Antihypertensive Activity ◽  
Carrier Protein ◽  
Binding Interaction ◽  
Site Specific ◽  
Chalcone Derivative ◽  
Delivery Mechanism

The usefulness of heterocyclic chalcone derivative as a therapeutic target in controlling hypertension and its site specific binding interaction with model transport protein to get a clear picture about its delivery mechanism.

scholarly journals Site-Specific Binding of Non-Site-Specific Ions

2019 ◽  
Vol 116 (12) ◽  
pp. 2237-2239 ◽  
Author(s):  
Shi-Jie Chen
Keyword(s):  
Specific Binding ◽  
Site Specific

scholarly journals Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 ◽  
Vol 6 (10) ◽  
pp. 1886-1898 ◽  
Author(s):  
J Bargonetti ◽  
I Reynisdottir ◽  
P N Friedman ◽  
C Prives
Keyword(s):  
Specific Binding ◽  
T Antigen ◽  
Mutant P53 ◽  
Wild Type ◽  
Sv40 T Antigen ◽  
Site Specific ◽  
Wild Type P53 ◽  
Cellular Dna

scholarly journals Probing enzymatic activity – a radical approach

2020 ◽  
Vol 11 (11) ◽  
pp. 2967-2972 ◽  
Author(s):  
Neil C. Taylor ◽  
Gary Hessman ◽  
Holger B. Kramer ◽  
Joanna F. McGouran
Keyword(s):  
Enzymatic Activity ◽  
Specific Binding ◽  
Deubiquitinating Enzymes ◽  
Binding Interaction ◽  
Latent Activity ◽  
Radical Approach

Latent activity-based probes have been developed for deubiquitinating enzymes using a thiol–ene strategy, labelling following a specific binding interaction.

scholarly journals Matrix formalism for site-specific binding of unstructured proteins to multicomponent lipid membranes

2008 ◽  
Vol 14 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Vladimir B. Teif ◽  
Daniel Harries ◽  
Dmitri Y. Lando ◽  
Avinoam Ben-Shaul
Keyword(s):  
Lipid Membranes ◽  
Specific Binding ◽  
Matrix Formalism ◽  
Site Specific ◽  
Unstructured Proteins

scholarly journals Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

2009 ◽  
Vol 30 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Vincent J Cunningham ◽  
Eugenii A Rabiner ◽  
Mark Slifstein ◽  
Marc Laruelle ◽  
Roger N Gunn
Keyword(s):  
Graphical Method ◽  
Quantitative Estimation ◽  
Specific Binding ◽  
Volume Of Distribution ◽  
Distribution Volume ◽  
Emission Tomography ◽  
Reference Region ◽  
Site Specific ◽  
Positron Emission ◽  
Regional Estimates

Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution ( VT) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bound radioligand ( VND) is also required to distinguish specific from total binding. However, a true reference region, devoid of specific binding, is often not available. We present a transformation of a graphical method, originally introduced by Lassen, using regional estimates of VT alone to determine occupancy, together with an extension that does not require baseline data.

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