scholarly journals A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide

2015 ◽  
Vol 3 (42) ◽  
pp. 8321-8327 ◽  
Author(s):  
Yulei Chang ◽  
Xiaodan Li ◽  
Xianggui Kong ◽  
Ye Li ◽  
Xiaomin Liu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Treatment Strategy ◽  
Photothermal Therapy ◽  
Charge Reversal ◽  
Image Guided ◽  
Highly Effective ◽  
Dual Imaging ◽  
Nir Dye ◽  
Guided Therapy

A new precision treatment strategy based on the dual photothermal agent of IR-806 NIR dye and iron oxide nanocomplex was constructed for efficient image-guided in vivo photothermal therapy (PTT).

scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer

ACS Nano ◽  
2012 ◽  
Vol 6 (6) ◽  
pp. 5605-5613 ◽  
Author(s):  
Liang Cheng ◽  
Kai Yang ◽  
Qian Chen ◽  
Zhuang Liu
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Effective ◽  
Stealth Nanoparticles

Ultrasound and photoacoustic image-guided photothermal therapy using silica-coated gold nanorods: In-vivo study

2010 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-Sheng Chen ◽  
Geoffrey P. Luke ◽  
Mohammad Mehrmohammadi ◽  
Jason R. Cook ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
In Vivo Study ◽  
Image Guided

In Vivo Image-Guided Therapy of Oral Carcinoma using Topical Photodynamic Molecular Beacons

2012 ◽  
Author(s):  
Tracy W. Liu ◽  
Eduardo H. Moriyama ◽  
Nicolas E. Wolter ◽  
Juan Chen ◽  
Brian C. Wilson ◽  
...  
Keyword(s):  
Molecular Beacons ◽  
Oral Carcinoma ◽  
Image Guided Therapy ◽  
Image Guided ◽  
Guided Therapy

scholarly journals Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 2718-2730 ◽  
Author(s):  
Hongbo Huang ◽  
Ke Li ◽  
Qingzhu Liu ◽  
Yunlei Zhao ◽  
Huiting Xu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
In Vivo Imaging ◽  
Potential Application ◽  
Photothermal Therapy ◽  
Ct Image ◽  
Image Guided ◽  
Clinical Cancer ◽  
Dual Response ◽  
Mno2 Nanoparticles

A stable multifunctional nanoplatform with superior biocompatibility and excellent targeting function was synthesized for MR/CT image guided PTT treatment, for potential application in clinical cancer treatment.

Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

2019 ◽  
Vol 6 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Xiaolei Cai ◽  
Aishwarya Bandla ◽  
Chan Kim Chuan ◽  
Gayathiri Magarajah ◽  
Lun-De Liao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumour Growth ◽  
Fluorescence Image ◽  
Organic Nanoparticles ◽  
Image Guided ◽  
In Vivo Fluorescence

Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

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