scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

scholarly journals Overview of DNA Self-Assembling: Progresses in Biomedical Applications

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 268 ◽  
Author(s):  
Andreia Jorge ◽  
Ramon Eritja
Keyword(s):  
Programming Languages ◽  
Biomedical Applications ◽  
Great Promise ◽  
Dna Nanostructures ◽  
Modular Assembly ◽  
Molecular Programming ◽  
Self Assembling ◽  
Theranostic Agents ◽  
Assembly Principles

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo.

Ultrasound and photoacoustic image-guided photothermal therapy using silica-coated gold nanorods: In-vivo study

2010 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-Sheng Chen ◽  
Geoffrey P. Luke ◽  
Mohammad Mehrmohammadi ◽  
Jason R. Cook ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
In Vivo Study ◽  
Image Guided

Upconversion Luminescence Imaging of Tumors with EGFR-Affibody Conjugated Nanophosphors

MRS Advances ◽  
2019 ◽  
Vol 4 (46-47) ◽  
pp. 2461-2470 ◽  
Author(s):  
Majid Badieirostami ◽  
Colin Carpenter ◽  
Guillem Pratx ◽  
Lei Xing ◽  
Conroy Sun
Keyword(s):  
Near Infrared ◽  
Imaging System ◽  
Imaging Modality ◽  
Photophysical Properties ◽  
Upconversion Luminescence ◽  
Detection Sensitivity ◽  
Photon Absorption ◽  
Great Promise

ABSTRACTNear infrared (NIR) optical imaging has demonstrated significant potential as an effective modality for cancer molecular imaging. Among various NIR probes currently under investigation, upconversion nanophosphors (UCNPs) possess great promise due to their anti-Stokes emission and sequential photon absorption which result in superior detection sensitivity and a simple imaging setup, respectively. Here we investigated the utility of this imaging modality to detect tumor cells expressing the epidermal growth factor receptor (EGFR) using affibody functionalized nanophosphors and a custom built imaging system. Initially, aqueous dispersible NaYF4: Tm+3, Yb+3 UCNPs were synthesized and their photophysical properties were characterized. Then, their luminescence response as a function of concentration and their depth resolving capability in a tissue-simulating phantom were examined. Finally, we demonstrated the use of bioconjugated UCNPs for imaging EGFR-expressing tumors both in vitro and in vivo. Our data suggests that NIR imaging with UCNPs may be useful for noninvasive imaging of tumors.

scholarly journals A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide

2015 ◽  
Vol 3 (42) ◽  
pp. 8321-8327 ◽  
Author(s):  
Yulei Chang ◽  
Xiaodan Li ◽  
Xianggui Kong ◽  
Ye Li ◽  
Xiaomin Liu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Treatment Strategy ◽  
Photothermal Therapy ◽  
Charge Reversal ◽  
Image Guided ◽  
Highly Effective ◽  
Dual Imaging ◽  
Nir Dye ◽  
Guided Therapy

A new precision treatment strategy based on the dual photothermal agent of IR-806 NIR dye and iron oxide nanocomplex was constructed for efficient image-guided in vivo photothermal therapy (PTT).

scholarly journals Synthesis of Yellow-Fluorescent Carbon Nano-dots by Microplasma for Imaging and Photocatalytic Inactivation of Cancer Cells

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xing Qin ◽  
Jinlin Liu ◽  
Qing Zhang ◽  
Wantao Chen ◽  
Xiaoxia Zhong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Imaging ◽  
Carbon Quantum Dots ◽  
Great Promise ◽  
Fluorescence Signal ◽  
Yellow Fluorescence ◽  
Bright Yellow ◽  
Relative Cell Viability ◽  
Fluorescent Carbon

AbstractIn recent years, multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise in nanomedicine. In this study, we report the environmentally friendly synthesis of fluorescent carbon nano-dots such as carbon quantum dots (CQDs) by microplasma using o-phenylenediamine. The produced CQDs exhibited a wide absorption peaks at 380–500 nm and emitted bright yellow fluorescence with a peak at 550 nm. The CQDs were rapidly taken up by HeLa cancer cells. When excited under blue light, a bright yellow fluorescence signal and intense reactive oxygen species (ROS) were efficiently produced, enabling simultaneous fluorescent cancer cell imaging and photodynamic inactivation, with a 40% decrease in relative cell viability. Furthermore, about 98% cells were active after the incubation with 400 μg mL−1 CQDs in the dark, which revealed the excellent biocompatibility of CQDs. Hence, the newly prepared CQDs are thus demonstrated to be materials which might be effective and safe to use for in vivo bioimaging and imaging-guided cancer therapy.

scholarly journals Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 2718-2730 ◽  
Author(s):  
Hongbo Huang ◽  
Ke Li ◽  
Qingzhu Liu ◽  
Yunlei Zhao ◽  
Huiting Xu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
In Vivo Imaging ◽  
Potential Application ◽  
Photothermal Therapy ◽  
Ct Image ◽  
Image Guided ◽  
Clinical Cancer ◽  
Dual Response ◽  
Mno2 Nanoparticles

A stable multifunctional nanoplatform with superior biocompatibility and excellent targeting function was synthesized for MR/CT image guided PTT treatment, for potential application in clinical cancer treatment.

Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

2019 ◽  
Vol 6 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Xiaolei Cai ◽  
Aishwarya Bandla ◽  
Chan Kim Chuan ◽  
Gayathiri Magarajah ◽  
Lun-De Liao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumour Growth ◽  
Fluorescence Image ◽  
Organic Nanoparticles ◽  
Image Guided ◽  
In Vivo Fluorescence

Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

GOLD NANOPARTICLES IN CANCER IMAGING AND THERAPEUTICS

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 289-307 ◽  
Author(s):  
HUANG-CHIAO HUANG ◽  
JAMES RAMOS ◽  
TARAKA SAI PAVAN GRANDHI ◽  
THRIMOORTHY POTTA ◽  
KAUSHAL REGE
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Clinical Investigation ◽  
Chemotherapeutic Agents ◽  
Great Promise ◽  
Fda Approval ◽  
Cancer Diseases ◽  
Nucleic Acid Drug

The use of nanomedicine in the war on cancer diseases has progressed significantly in the recent past. Liposomal- and albumin-based chemotherapeutic agents as well as tumor contrast agents (e.g. Gd-DTPA, ferumoxides) have received FDA approval for human clinical use, while many other agents are in different phases of pre-clinical investigation and clinical trials. Plasmonic gold nanoparticles hold great promise as potential theranostic devices for detection and ablation of cancer diseases. This review discusses recent progress in the imaging, photothermal therapy, and nucleic acid/drug delivery using gold nanoparticles (spheres, shells, rods, cages) in vitro and in vivo. Issues relating to toxicity, biocompatibility, biodistribution, cellular uptake, and targeting efficiency are also discussed.

scholarly journals Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications

2017 ◽  
Author(s):  
Hai Feng Zeng ◽  
Mu Yang Sun ◽  
Su Fan Wu ◽  
Hai Feng Chen
Keyword(s):  
Crystal Structure ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Great Promise ◽  
Drug Molecules ◽  
Model Drug ◽  
New Feature ◽  
A375 Cells

Europium (Eu)-doped fluorapatite (FA) nanorods has a similar biocompatibility with hydroxyapatite (HA) in terms, attracted much attention as cell imaging biomaterials due to their luminescent property. Here, we will discuss the new feature of europium doped fluorapatite (Eu-FA) nanorods as anticancer drug carrier. Eu-FA nanorods was prepared using a hydrothermal method. The morphology, crystal structure, fluorescence and composition are investigated. The specific crystal structure, enabling an effective loading of drug molecules. Doxorubicin (DOX), used as an anticancer model drug, was shown to be effectively loaded onto the surface of the nanorods. The DOX release was fairly pH-dependent, occurring more rapidly at pH 5.5 than pH 7.4 was observed. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA show great promise for tracking and treating tumor, may potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs.

scholarly journals Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (17) ◽  
pp. 7885-7895 ◽  
Author(s):  
Hui Wang ◽  
Guixin Cao ◽  
Zheng Gai ◽  
Kunlun Hong ◽  
Probal Banerjee ◽  
...  
Keyword(s):  
Drug Release ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Hybrid Nanoparticles ◽  
Fluorescent Carbon

Multifunctional hybrid nanoparticles have been developed for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy.

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