Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery

The contribution of the surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery, including adsorption, sustained release, cellular uptake and endo/lysosomal escape.

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Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery

Journal of Materials Chemistry B ◽

10.1039/c5tb01405k ◽

2015 ◽

Vol 3 (43) ◽

pp. 8477-8485 ◽

Cited By ~ 28

Author(s):

Yuting Niu ◽

Meihua Yu ◽

Jun Zhang ◽

Yannan Yang ◽

Chun Xu ◽

...

Keyword(s):

Surface Roughness ◽

Silica Nanoparticles ◽

Protein Delivery ◽

Therapeutic Protein ◽

Antibody Delivery

Silica nanoparticles with controllable surface roughness have been successfully prepared for therapeutic anti-pAkt antibody delivery.

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Multi-stage, charge conversional, stimuli-responsive nanogels for therapeutic protein delivery

Biomaterials Science ◽

10.1039/c5bm00171d ◽

2015 ◽

Vol 3 (11) ◽

pp. 1487-1496 ◽

Cited By ~ 25

Author(s):

Xuejiao Zhang ◽

Kai Zhang ◽

Rainer Haag

Keyword(s):

Cellular Uptake ◽

Protein Delivery ◽

Therapeutic Protein ◽

Extracellular Ph ◽

Endosomal Escape ◽

Stimuli Responsive ◽

Two Stage ◽

Second Stage ◽

Multi Stage ◽

Intracellular Organelles

A two-stage charge conversional nanogel with ATP/pH-sensitivity was generated. The first-stage charge conversion at tumor extracellular pH can enhance the tumor cellular uptake and the second-stage charge conversion in the acidic intracellular organelles (endo/lysosome) can result in the endosomal escape.

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Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

Materials Science and Engineering C ◽

10.1016/j.msec.2020.111619 ◽

2021 ◽

Vol 119 ◽

pp. 111619

Author(s):

Paul Jänicke ◽

Claudia Lennicke ◽

Annette Meister ◽

Barbara Seliger ◽

Ludger A. Wessjohann ◽

...

Keyword(s):

Mesoporous Silica ◽

Anticancer Activity ◽

Silica Nanoparticles ◽

Cellular Uptake ◽

Mesoporous Silica Nanoparticles

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pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo

Journal of Biomaterials Applications ◽

10.1177/0885328216637211 ◽

2016 ◽

Vol 31 (1) ◽

pp. 23-35 ◽

Cited By ~ 26

Author(s):

Xuecheng Xiao ◽

Yangyang Liu ◽

Manman Guo ◽

Weidong Fei ◽

Hongyue Zheng ◽

...

Keyword(s):

Mesoporous Silica ◽

Sustained Release ◽

Silica Nanoparticles ◽

Arsenic Trioxide ◽

Solid Tumor ◽

Polyacrylic Acid ◽

Mesoporous Silica Nanoparticles ◽

Tumor Treatment

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Surface roughness influences the protein corona formation of glycosylated nanoparticles and alter their cellular uptake

Nanoscale ◽

10.1039/c9nr06835j ◽

2019 ◽

Vol 11 (48) ◽

pp. 23259-23267 ◽

Cited By ~ 8

Author(s):

Alberto Piloni ◽

Chin Ken Wong ◽

Fan Chen ◽

Megan Lord ◽

Andreas Walther ◽

...

Keyword(s):

Surface Roughness ◽

Cellular Uptake ◽

Protein Corona ◽

Biological Behavior ◽

Protein Absorption ◽

Corona Formation

Patterned nanoparticle surfaces can repel protein absorption and prevent the formation of a protein corona, which alters the biological behavior and therefore the fate of the nanoparticle.

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