Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery

2015 ◽  
Vol 3 (43) ◽  
pp. 8477-8485 ◽  
Author(s):  
Yuting Niu ◽  
Meihua Yu ◽  
Jun Zhang ◽  
Yannan Yang ◽  
Chun Xu ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Silica Nanoparticles ◽  
Protein Delivery ◽  
Therapeutic Protein ◽  
Antibody Delivery

Silica nanoparticles with controllable surface roughness have been successfully prepared for therapeutic anti-pAkt antibody delivery.

Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery

2016 ◽  
Vol 4 (2) ◽  
pp. 212-219 ◽  
Author(s):  
Yuting Niu ◽  
Meihua Yu ◽  
Anand Meka ◽  
Yang Liu ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Sustained Release ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Protein Delivery ◽  
Therapeutic Protein ◽  
Hydrophobic Modification

The contribution of the surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery, including adsorption, sustained release, cellular uptake and endo/lysosomal escape.

Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Small ◽  
2015 ◽  
Vol 11 (44) ◽  
pp. 5949-5955 ◽  
Author(s):  
Chun Xu ◽  
Meihua Yu ◽  
Owen Noonan ◽  
Jun Zhang ◽  
Hao Song ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Large Cavity

Core-Shell-structured Dendritic Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Antibody Delivery

2017 ◽  
Vol 12 (13) ◽  
pp. 1465-1469 ◽  
Author(s):  
Prasanna Lakshmi Abbaraju ◽  
Yannan Yang ◽  
Meihua Yu ◽  
Jianye Fu ◽  
Chun Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Core Shell ◽  
Antibody Delivery

On the surface roughness and hydrophobicity of dual-size double-layer silica nanoparticles

2013 ◽  
Vol 48 (18) ◽  
pp. 6115-6120 ◽  
Author(s):  
Thushara J. Athauda ◽  
Wesley Williams ◽  
Kenneth P. Roberts ◽  
Ruya R. Ozer
Keyword(s):  
Surface Roughness ◽  
Silica Nanoparticles ◽  
Double Layer

Improved properties of corn fiber-reinforced polylactide composites by incorporating silica nanoparticles at interfaces

2019 ◽  
Vol 28 (3) ◽  
pp. 170-179 ◽  
Author(s):  
Honglin Luo ◽  
Zhiwei Yang ◽  
Fanglian Yao ◽  
Wei Li ◽  
Yizao Wan
Keyword(s):  
Mechanical Properties ◽  
Surface Roughness ◽  
Crack Propagation ◽  
Silica Nanoparticles ◽  
Industrial Applications ◽  
Corn Fiber ◽  
Great Promise ◽  
Fiber Reinforced ◽  
Novel Strategy

In this work, we report a novel strategy for improving the interfacial nature in corn fiber/polylactide (CRF/PLA) composites by directly applying a sizing containing silica nanoparticles on the surface of CRFs. This results in enhanced mechanical properties of the CRF/PLA composites. These improvements can be mainly attributed to the presence of silica nanoparticles on CRF-PLA interfaces, which act to resist the crack propagation. The increased surface roughness of CRFs from incorporated silica nanoparticles may also contribute to the enhanced mechanical properties. This simple methodology can be easily scaled up and thus shows great promise in industrial applications.

Protein nanoparticles for therapeutic protein delivery

2015 ◽  
Vol 3 (6) ◽  
pp. 787-799 ◽  
Author(s):  
L. P. Herrera Estrada ◽  
J. A. Champion
Keyword(s):  
Self Assembly ◽  
Protein Delivery ◽  
Therapeutic Proteins ◽  
Therapeutic Protein ◽  
Protein Nanoparticles

This review describes nanoparticles made from protein by self-assembly or desolvation as carriers for the delivery of therapeutic proteins.

scholarly journals Chemotherapeutic, Toxin, and Therapeutic Protein Delivery via Nucleolin Aptamer-functionalized Nanoplatforms for Targeted Cancer Therapy

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Pouya Safarzadeh Kozani ◽  
Pooria Safarzadeh Kozani ◽  
Fatemeh Rahbarizadeh
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Protein Delivery ◽  
Therapeutic Potential ◽  
Therapeutic Protein ◽  
Targeted Cancer Therapy ◽  
Chemotherapeutic Drugs ◽  
Different Types ◽  
As1411 Aptamer ◽  
Targeting Peptide

: Nucleolin is a protein abundantly present in the nucleolus, but its expression on the surface of cells is potentially associated with various types of malignancies. So far, several nucleolin-targeting strategies, including the nucleolin-targeting peptide, anti-nucleolin pseudopeptides, anti-nucleolin antibodies, and the anti-nucleolin aptamer, AS1411, have been developed and investigated in different types of studies. The AS1411 aptamer has been known as the outstanding approach for targeting nucleolin with superior specificity and therapeutic potential in comparison with other targeting strategies. In this review, we highlight different nucleolin-targeting strategies for the targeted delivery of chemotherapeutic drugs, proteins with therapeutic potential, and toxins.

Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery

2018 ◽  
Vol 30 (29) ◽  
pp. 1801198 ◽  
Author(s):  
Dan Shao ◽  
Mingqiang Li ◽  
Zheng Wang ◽  
Xiao Zheng ◽  
Yeh-Hsing Lao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Responsive
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