Investigation of the effect of cucurbit[7]uril complexation on the photophysical and acid–base properties of the antimalarial drug quinine

2016 ◽  
Vol 18 (44) ◽  
pp. 30520-30529 ◽  
Author(s):  
Suman Mallick ◽  
Kaushik Pal ◽  
Falguni Chandra ◽  
Apurba L. Koner
Keyword(s):  
Antimalarial Drug ◽  
Chemical Properties ◽  
Acid Base ◽  
Physico Chemical ◽  
Base Properties

Tuning the physico-chemical properties of an anti-malarial drug upon cucurbit[7]uril encapsulation.

scholarly journals Peculiarities of acid-base properties of peat formed in various agroclimatic zones of the Altai mountainous region

2021 ◽  
Vol 928 (1) ◽  
pp. 012003
Author(s):  
G V Larina ◽  
E V Kaigorodov ◽  
E B Daibova ◽  
O A Yalbacheva ◽  
L G Vidyaykina
Keyword(s):  
Chemical Properties ◽  
Base Saturation ◽  
Degree Of Saturation ◽  
Regression Equations ◽  
Mountainous Region ◽  
Acid Base ◽  
Raised Bog ◽  
Exchangeable Acidity ◽  
Physico Chemical ◽  
Agroclimatic Zones

Abstract The results of the study of acid-base indicators of peat in the Altai mountainous region are presented. The natural factors that in the aggregate determine the peculiarities of the physico-chemical properties of mountain peat of different agro-climatic zones of the Altai Mountains have been revealed. The variation in the acid values, total absorbed bases, adsorption capacity and the degree of saturation of raised-bog, transitional, fen peat, the number of exchangeable ions Ca2+ and Mg2+ has been estimated. The interrelation among these indicators has been presented. For the first time, regression equations of the relationship between exchangeable acidity pHKC1 and the degree of peat base saturation V, between total absorbed bases S and the degree of peat base saturation V have been obtained using nonlinear regression analysis. The adequacy and stability of the developed models have been verified. The calculated mean errors of approximation of regression models characterise the high accuracy of the forecast and are indicative of a good selection of models for the initial data.

Structural and physico-chemical properties of insoluble rice bran fiber: effect of acid–base induced modifications

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79915-79923 ◽  
Author(s):  
Jing Qi ◽  
Wallace Yokoyama ◽  
Kingsley George Masamba ◽  
Hamid Majeed ◽  
Fang Zhong ◽  
...  
Keyword(s):  
Rice Bran ◽  
Chemical Properties ◽  
Acid Base ◽  
Physico Chemical

Various acid–base regimes induced structural and physicochemical modifications of IRBF.

scholarly journals Physico-chemical properties of N-(2-Hydroxybenzoyl)-N'-(p-Tosil) Hydrazine

2021 ◽  
Vol 11 (1) ◽  
pp. 71-81
Author(s):  
Yulia B. Elchishcheva ◽  
◽  
Ksenia S. Gorbunova ◽  
Petr T. Pavlov ◽  
◽  
...  
Keyword(s):  
Dissociation Constants ◽  
Hydrolytic Stability ◽  
Chemical Properties ◽  
Alkaline Media ◽  
Acid Dissociation ◽  
Degree Of Hydrolysis ◽  
Acid Base ◽  
Acid Dissociation Constants ◽  
Physico Chemical ◽  
Over Time

The results of a study of the physicochemical properties of N- (2-hydroxybenzoyl) -N '- (p-tosyl) hydrazine (GBSH) are presented. The solubility of the reagent in ethanol, 0.1 mol / L KOH solution, toluene, chloroform, hexane was studied by spectrophotometry, refractometry, and gravimetry. Based on the results obtained, it was shown that GBSG can be used in the processes of flotation and extraction. Acid-base equilibria in reagent solutions were studied spectrophotometrically. The obtained values of the acid dissociation constants (pKa1 = 7.93 ± 0.34; pKa2 = 10.48 ± 0.15) prove that GBSH is a weak diacid. The hydrolytic stability of the reagent was studied by the spectrophotometric method. The results of the study showed that HBHS solutions are sufficiently stable over time in alkaline media: the degree of hydrolysis within two hours is 2.35%. The surface activity of the reagent was determined by the stalagmometric method. It has been established that GBSG is a surfactant.

scholarly journals Physico-chemical Profiling of ACE-inhibitor Lisinopril: Acid-base Properties

ADMET & DMPK ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Krisztina Takacs-Novak ◽  
Katalin Deak ◽  
Szabolcs Beni ◽  
Gergely Volgyi
Keyword(s):  
Ace Inhibitor ◽  
Acid Base ◽  
Chemical Profiling ◽  
Physico Chemical ◽  
Base Properties

pH-Responsive Interaction of Fluorogenic Antimalarial Drug Quinine with Macrocyclic Host Cucurbit[7]uril: Modulations in Photophysical and Acid-Base Properties

2017 ◽  
Vol 2 (18) ◽  
pp. 5128-5142 ◽  
Author(s):  
Deepak R. Boraste ◽  
Goutam Chakraborty ◽  
Alok K. Ray ◽  
Ganapati S. Shankarling ◽  
Haridas Pal
Keyword(s):  
Antimalarial Drug ◽  
Ph Responsive ◽  
Acid Base ◽  
Base Properties

Decoration of specific sites on freeze-fractured membranes

1978 ◽  
Vol 36 (2) ◽  
pp. 140-141
Author(s):  
H. Gross ◽  
H. Moor
Keyword(s):  
Pure Water ◽  
Freeze Fracture ◽  
Chemical Properties ◽  
Surface Forces ◽  
Sulfate Pentahydrate ◽  
Copper Sulfate Pentahydrate ◽  
Physico Chemical ◽  
Water Of Hydration ◽  
Small Container ◽  
Binding Forces

Fracturing under ultrahigh vacuum (UHV, p ≤ 10-9 Torr) produces membrane fracture faces devoid of contamination. Such clean surfaces are a prerequisite foe studies of interactions between condensing molecules is possible and surface forces are unequally distributed, the condensate will accumulate at places with high binding forces; crystallites will arise which may be useful a probes for surface sites with specific physico-chemical properties. Specific “decoration” with crystallites can be achieved nby exposing membrane fracture faces to water vopour. A device was developed which enables the production of pure water vapour and the controlled variation of its partial pressure in an UHV freeze-fracture apparatus (Fig.1a). Under vaccum (≤ 10-3 Torr), small container filled with copper-sulfate-pentahydrate is heated with a heating coil, with the temperature controlled by means of a thermocouple. The water of hydration thereby released enters a storage vessel.

Physico-Chemical Properties of Recombinant Desulphatohirudin

1990 ◽  
Vol 63 (03) ◽  
pp. 499-504 ◽  
Author(s):  
A Electricwala ◽  
L Irons ◽  
R Wait ◽  
R J G Carr ◽  
R J Ling ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gel Filtration ◽  
Chemical Properties ◽  
Alpha Helix ◽  
Apparent Molecular Weight ◽  
Correlation Spectroscopy ◽  
Nmr Studies ◽  
Recombinant Hirudin ◽  
Physico Chemical ◽  
Recombinant Molecule

SummaryPhysico-chemical properties of recombinant desulphatohirudin expressed in yeast (CIBA GEIGY code No. CGP 39393) were reinvestigated. As previously reported for natural hirudin, the recombinant molecule exhibited abnormal behaviour by gel filtration with an apparent molecular weight greater than that based on the primary structure. However, molecular weight estimation by SDS gel electrophoresis, FAB-mass spectrometry and Photon Correlation Spectroscopy were in agreement with the theoretical molecular weight, with little suggestion of dimer or aggregate formation. Circular dichroism studies of the recombinant molecule show similar spectra at different pH values but are markedly different from that reported by Konno et al. (13) for a natural hirudin-variant. Our CD studies indicate the presence of about 60% beta sheet and the absence of alpha helix in the secondary structure of recombinant hirudin, in agreement with the conformation determined by NMR studies (17)

Physico-chemical properties of the rare-earth metals, scandium, and yttrium

1963 ◽  
Vol 79 (2) ◽  
pp. 263-293 ◽  
Author(s):  
E.M. Savitskii ◽  
V.F. Terekhova ◽  
O.P. Naumkin
Keyword(s):  
Rare Earth ◽  
Rare Earth Metals ◽  
Chemical Properties ◽  
Physico Chemical ◽  
The Rare Earth
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