How does the chain length of PEG functionalized at the outer surface of mesoporous silica nanoparticles alter the uptake of molecules?

2016 ◽  
Vol 40 (9) ◽  
pp. 8060-8067 ◽  
Author(s):  
Leandro C. Fonseca ◽  
Amauri J. de Paula ◽  
Diego Stéfani T. Martinez ◽  
Oswaldo L. Alves
Keyword(s):  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Chain Length ◽  
Outer Surface ◽  
Mesoporous Silica Nanoparticles

Polyethylene glycol when attached to the outer surface of MSNs alters the incorporation of curcumin and also its release properties.

Selective functionalization of the outer surface of MCM-48-type mesoporous silica nanoparticles at room temperature

2020 ◽  
Vol 22 (9) ◽  
Author(s):  
Shewaye Yismaw ◽  
Stefan G. Ebbinghaus ◽  
Marianne Wenzel ◽  
David Poppitz ◽  
Roger Gläser ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Outer Surface ◽  
Room Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Selective Functionalization

A combined “RAFT” and “Graft From” polymerization strategy for surface modification of mesoporous silica nanoparticles: towards enhanced tumor accumulation and cancer therapy efficacy

2014 ◽  
Vol 2 (35) ◽  
pp. 5828-5836 ◽  
Author(s):  
Ming Ma ◽  
Shuguang Zheng ◽  
Hangrong Chen ◽  
Minghua Yao ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Polyethylene Glycol ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapy Efficacy ◽  
Tumor Accumulation

A novel modification route integrating the copolymers of positive charged quaternary amines and polyethylene glycol units using a combination “Raft” and “Graft From” strategy.

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59576-59582 ◽  
Author(s):  
Huameng Gong ◽  
Zhifei Xie ◽  
Mingxing Liu ◽  
Hongda Zhu ◽  
Honghao Sun
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Thiol Group ◽  
Anticancer Drug Delivery ◽  
Methoxy Polyethylene Glycol

In this paper, redox-sensitive mesoporous silica nanoparticles (MSNs–SS–PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs–SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG–SH).

Monodisperse Rattle-Structured Gold Nanorod-Mesoporous Silica Nanoparticles Core–Shell as Sulforaphane Carrier and its Sustained-Release Property

Drug Research ◽  
2018 ◽  
Vol 68 (09) ◽  
pp. 504-513
Author(s):  
Hamidreza Manjili ◽  
Leila Ma’mani ◽  
Hossein Naderi-Manesh
Keyword(s):  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Line ◽  
Mesoporous Silica Nanoparticles ◽  
Gold Nanorod ◽  
Core Shell ◽  
Au Nps ◽  
Mcf 7 ◽  
Thiolated Polyethylene Glycol

Sulforaphane (SF) was loaded into the multi-functioned rattle-structured gold nanorod mesoporous silica nanoparticles core-shell to improve its stability and efficacy through its efficient delivery to tumors. The rattle-structured gold nanorod mesoporous silica nanoparticles (rattle-structured AuNR@mSiO2 core-shell NPs) were obtained by covering the surface of Au NPs with Ag and mSiO2 shell and subsequently selective Ag shell etching strategy. Then the surface of rattle-structured AuNR@mSiO2 NPs was decorated with thiolated polyethylene glycol-FITC and thiolated polyethylene glycol-folic acid to the designed form. The obtained FITC/FA@ [rattle-structured AuNR@mSiO2] NPs was characterized by different techniques including energy dispersive X-ray spectroscopy (EDX), scanning and transmission electron microscopy (SEM & TEM), UV-visible spectrophotometer and dynamic light scattering (DLS). The FITC/FA@ [rattle-structured AuNR@mSiO2] NPs has an average diameter around ~33 nm, which increases to ~38 nm after the loading of sulforaphane. The amount of the loaded drug was ~ 2.8×10-4 mol of SF per gram of FITC/FA@ [rattle-structured AuNR@mSiO2] NPs. The rattle-structured AuNR@mSiO2 and FITC/FA@ [rattle-structured AuNR@mSiO2] NPs showed little inherent cytotoxicity, whereas the SF loaded FITC/FA@ [rattle-structured AuNR@mSiO2] NPs was highly cytotoxic in the case of MCF-7 cell line. Finally, Fluorescence microscopy and flow cytometry were used to demonstrate that the nanoparticles could be accumulated in specific regions and SF loaded FITC/FA@ [Fe3O4@Au] NPs efficiently induce apoptosis in MCF-7 cell line Graphical Abstract.

scholarly journals Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

2018 ◽  
Vol 168 ◽  
pp. 50-59 ◽  
Author(s):  
Valentina Nairi ◽  
Silvia Magnolia ◽  
Marco Piludu ◽  
Mariella Nieddu ◽  
Cristian Antonio Caria ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Chain Length ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Internalization ◽  
Acid Effect
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