Design, synthesis and characterization of new 1,2,3-triazolyl pyrazole derivatives as potential antimicrobial agents via a Vilsmeier–Haack reaction approach

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59375-59388 ◽  
Author(s):  
Manjunatha Bhat ◽  
Nagaraja G. K. ◽  
Reshma Kayarmar ◽  
Peethamber S. K. ◽  
Mohammed Shafeeulla R
Keyword(s):  
Antimicrobial Agents ◽  
Synthesis And Characterization ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Anti Oxidant ◽  
Anti Fungal

A new series of 1,2,3-triazolyl pyrazole derivatives were synthesisedviaa Vilsmeier–Haack reaction approach and screened for theirin vitroanti-bacterial, anti-fungal and anti-oxidant activities.

Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel pyrazole derivatives as antimicrobial agents

2022 ◽  
Author(s):  
Mohammed CHALKHA ◽  
Mohamed Akhazzane ◽  
Fatima Zahrae Moussaid ◽  
Ossama Daoui ◽  
Asmae Nakkabi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antimicrobial Agents ◽  
3D Qsar ◽  
Spectroscopic Techniques ◽  
In Vitro Screening ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Practical Procedure

In this work, we report the synthesis of some new pyrazole derivatives via an efficient and practical procedure. The structures of the obtained compounds were established using different spectroscopic techniques...

Design, synthesis, and characterization of 6β-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes

2009 ◽  
Vol 19 (10) ◽  
pp. 2811-2814 ◽  
Author(s):  
Andrea L. Pelotte ◽  
Ryan M. Smith ◽  
Mario Ayestas ◽  
Christina M. Dersch ◽  
Edward J. Bilsky ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Synthesis And Characterization ◽  
Receptor Subtypes ◽  
Design Synthesis ◽  
Opioid Receptor Subtypes

Design, synthesis and characterization of peptidyl boronate analogues as effective antimicrobial agents

2017 ◽  
Vol 43 (10) ◽  
pp. 5755-5778 ◽  
Author(s):  
D. V. R. Venugopal ◽  
Amperayani Karteek Rao ◽  
Parimi Uma Devi ◽  
Y. N. Sastry ◽  
K. Aruna Lakshmi ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Synthesis And Characterization ◽  
Design Synthesis

scholarly journals Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

2004 ◽  
Vol 1 (5) ◽  
pp. 228-230 ◽  
Author(s):  
S. R. Dhol ◽  
P. M. Gami ◽  
R. C. Khunt ◽  
A. R. Parikh
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Carbon Disulfide ◽  
Acid Chloride ◽  
Potassium Hydroxide ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Elemental Analyses

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassiumα,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for theirin vitroin vitro antimicrobial activity.

Synthesis and Characterization of Novel 1,3,5-Thiadiazine Derivatives Integrated with Quinoline Moiety as Potent Antimicrobial Agents

2020 ◽  
Vol 5 (2) ◽  
pp. 149-155
Author(s):  
M. Idrees ◽  
Naqui J. Siddiqui ◽  
Yogita G. Bodkhe ◽  
Satish Kola
Keyword(s):  
13C Nmr ◽  
Mass Spectra ◽  
Antimicrobial Agents ◽  
Synthesis And Characterization ◽  
Pathogenic Microorganism ◽  
Bacterial Strains ◽  
Gram Negative ◽  
E Coli

An expeditious synthesis of series of novel 1,3,5-thiadiazine (5a-f) and (6a-f) derivatives have been described. These compounds were synthesized by reaction of 1-(N-((6-methyl-2-(p-tolyloxy)quinoline- 3-yl)methylene)carbamimidoyl)-3-arylthiourea (3a-b) derivatives with N-aryl isocyanodichloride (4a-c) in chloroform followed by basification with dilute NH4OH to give the target compounds 5a-f; which were acetylated further to afford six novel 1,3,5-thiadiazin-3-(6H)-yl)ethanone (6a-f) derivatives. Synthesis of intermediate compounds 3a-b was obtained by reacting 6-methyl-2-(p-tolyloxy)quinoline-3- carbaldehyde (2a) and 1-carbamimidoyl-3-aryllthiourea (1a-b) in chloroform. Structures of compounds 5a-f and 6a-f were established by FTIR, 1H & 13C NMR, mass spectra and further supported by elemental analysis. All synthesized compounds were investigated for their in vitro antimicrobial screening against a panel of pathogenic microorganism comprising S. aureus as Gram positive while E. coli, P. vulgaris, S. typhi as Gram-negative bacterial strains.

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