Design, synthesis and characterization of tin-based cancer chemotherapy drug entity: In vitro DNA binding, cleavage, induction of cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation and molecular docking

2018 ◽  
Vol 33 (1) ◽  
pp. e4651 ◽  
Author(s):  
Sabah Ahmed Abdo Esmail ◽  
Manal Shamsi ◽  
Tianfeng Chen ◽  
Waddhaah M. Al-asbahy
Keyword(s):  
Dna Damage ◽  
Molecular Docking ◽  
Dna Binding ◽  
Cancer Cell ◽  
Cancer Chemotherapy ◽  
Cell Apoptosis ◽  
Synthesis And Characterization ◽  
Design Synthesis

Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes: In vitro DNA binding, cleavage, and antitumor activities

Polyhedron ◽  
2015 ◽  
Vol 85 ◽  
pp. 93-103 ◽  
Author(s):  
Mouayed A. Hussein ◽  
Teoh S. Guan ◽  
Rosenani A. Haque ◽  
Mohamed B. Khadeer Ahamed ◽  
Amin M.S. Abdul Majid
Keyword(s):  
Dna Binding ◽  
Synthesis And Characterization ◽  
Antitumor Activities

Design, synthesis, and characterization of 6β-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes

2009 ◽  
Vol 19 (10) ◽  
pp. 2811-2814 ◽  
Author(s):  
Andrea L. Pelotte ◽  
Ryan M. Smith ◽  
Mario Ayestas ◽  
Christina M. Dersch ◽  
Edward J. Bilsky ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Synthesis And Characterization ◽  
Receptor Subtypes ◽  
Design Synthesis ◽  
Opioid Receptor Subtypes

scholarly journals Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

2004 ◽  
Vol 1 (5) ◽  
pp. 228-230 ◽  
Author(s):  
S. R. Dhol ◽  
P. M. Gami ◽  
R. C. Khunt ◽  
A. R. Parikh
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Carbon Disulfide ◽  
Acid Chloride ◽  
Potassium Hydroxide ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Elemental Analyses

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassiumα,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for theirin vitroin vitro antimicrobial activity.

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