Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassiumα,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for theirin vitroin vitro antimicrobial activity.

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Synthesis and characterization of barbitones as antimicrobial agents

Journal of the Serbian Chemical Society ◽

10.2298/jsc0606587s ◽

2006 ◽

Vol 71 (6) ◽

pp. 587-591 ◽

Cited By ~ 6

Author(s):

H.G. Sangani ◽

K.B. Bhimani ◽

R.C. Khunt ◽

A.R. Parikh

Keyword(s):

Antimicrobial Activity ◽

Barbituric Acid ◽

Antimicrobial Agents ◽

Spectral Studies ◽

Synthesis And Characterization ◽

Mass Spectral ◽

Elemental Analyses ◽

Bacteria And Fungi

Barbitones (3) were synthesised by the condensation of chalcones (2) with barbituric acid. The structure of the synthesized compounds were assigned on the basis of elemental analyses, IR, NMR and mass spectral studies. All the products were evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi.

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DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.39745 ◽

2020 ◽

pp. 125-134

Author(s):

SURENDRA BABU LAGU ◽

RAJENDRA PRASAD YEJELLA

Keyword(s):

Antimicrobial Activity ◽

Antioxidant Activity ◽

Antimicrobial Activities ◽

Docking Studies ◽

Synthesis And Characterization ◽

Zone Of Inhibition ◽

Design Synthesis ◽

Instrumental Methods ◽

Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

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Design, synthesis and characterization of a series of 6-substituted-4-hydroxy-1-(2-substituted thiazol-4-yl)quinolin-2(1<em>H</em>)-one derivatives and evaluation of their <em>in vitro </em>anticancer and antibacterial activity

10.3390/ecmc2021-11398 ◽

2021 ◽

Author(s):

Soniya Phadte ◽

S.N Dessai ◽

Sachin Chandavarkar ◽

Sanket Naik ◽

Priyanka Tiwari

Keyword(s):

Antibacterial Activity ◽

Synthesis And Characterization ◽

Design Synthesis

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Synthesis and characterization of new Oxazine , Thiazine and Pyrazol derived from chalcones

Baghdad Science Journal ◽

10.21123/bsj.11.2.477-485 ◽

2014 ◽

Vol 11 (2) ◽

pp. 477-485 ◽

Cited By ~ 1

Author(s):

Baghdad Science Journal

Keyword(s):

Nmr Spectroscopy ◽

Hydrazine Hydrate ◽

Elemental Analysis ◽

Potassium Hydroxide ◽

1H Nmr Spectroscopy ◽

Room Temperature ◽

Potassium Hydroxide Solution ◽

Synthesis And Characterization ◽

Heterocyclic Derivatives

In this study, chalcones were synthesis by condensing 2-acetylpyridine with aromatic aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. After that, new heterocyclic derivatives such as Oxazine, Thiazine and Pyrazol were synthesis by reaction between chalcones with urea, thiourea and hydrazine hydrate respectively scheme 1. All these compounds wrer characterization by FTIR, 1H-NMR spectroscopy and elemental analysis.

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