scholarly journals Design and development of a nanoemulsion system containing extract of Clinacanthus nutans (L.) leaves for transdermal delivery system by D-optimal mixture design and evaluation of its physicochemical properties

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 67378-67388 ◽  
Author(s):  
Intan Soraya Che Sulaiman ◽  
Mahiran Basri ◽  
Hamid Reza Fard Masoumi ◽  
Siti Efliza Ashari ◽  
Maznah Ismail
Keyword(s):  
Medicinal Plant ◽  
Physicochemical Properties ◽  
East Asia ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Mixture Design ◽  
South East Asia ◽  
Design And Development ◽  
Clinacanthus Nutans ◽  
Transdermal Delivery System

C. nutansis a well-known medicinal plant in South-East Asia that has attracted attention for its therapeutic characteristics. In this work, nanoemulsion has been chosen to be a carrier in encapsulation ofC. nutansextract for its potential in nanotechnology application.

scholarly journals Pluronic lecithin organogel with d-limonene as a transdermal delivery system for Kaempferia parviflora extract

2018 ◽  
Vol 192 ◽  
pp. 01008
Author(s):  
Worranan Rangsimawong ◽  
Paisit Wattanasri ◽  
Prasert Akkaramongkolporn ◽  
Prasopchai Tonglairoum ◽  
Tanasait Ngawhirunpat ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Water Solubility ◽  
Skin Permeation ◽  
Storage Condition ◽  
Poloxamer 407 ◽  
Kaempferia Parviflora ◽  
Transdermal Delivery System

Kaempferia parviflora (KP) extract has been used in the Thai medicinal plant recipe, which the methoxyflavones are the main active compound. These compounds have low water solubility, high lipophilicity, and low bioavailability. The aim of this study was to develop the pluronic lecithin organogel (PLO) and PLO with d-limonene (PLO-L) for enhancing transdermal delivery of KP extract. These formulations were prepared and their physicochemical properties, stability, and in vitro skin permeation were evaluated. For the result, all formulations exhibited good physicochemical properties and stable under storage condition for 3 months. The permeation of KP extract-loaded PLO-L and PLO formulation showed significantly higher total methoxyflavones permeated through the skin than KP extract in water, which PLO-L provided the highest permeated flux of total methoxyflavones. This result suggested that d-limonene play a role as skin permeation enhancer. Organogel consisting of poloxamer 407 and lecithin also increased the skin permeation of KP extract. In conclusion, PLO-L could be a potential transdermal delivery system for KP extract.

A statistical approach to the development of a transdermal delivery system for ondansetron

2010 ◽  
Vol 399 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Yasuko Obata ◽  
Yuriko Ashitaka ◽  
Shingo Kikuchi ◽  
Koichi Isowa ◽  
Kozo Takayama
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Statistical Approach ◽  
Transdermal Delivery System

scholarly journals Development and In vitro Evaluation of Betahistine Adhesive-Type Transdermal Delivery System

2011 ◽  
Vol 9 (6) ◽  
Author(s):  
Ashish A Heda ◽  
Aravind R Sonawane ◽  
Gautam H Naranje ◽  
Vijay G Somani ◽  
Prashant K Puranik
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Delivery System ◽  
Adhesive Type

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers

2021 ◽  
Vol 27 ◽  
Author(s):  
Sana Kalave ◽  
Bappaditya Chatterjee ◽  
Parth Shah ◽  
Ambikanandan Misra
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Nanostructured Lipid Carriers ◽  
Skin Damage ◽  
Low Frequency Ultrasound ◽  
Transdermal Delivery System ◽  
Nanolipid Carriers ◽  
Transport Of Macromolecules ◽  
Frequency Ultrasound

: Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement in macromolecules' transdermal delivery occurred in recent years. Scientists have opted for liposomes, the use of electroporation or, low-frequency ultrasound techniques. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) are widely investigated as a transdermal delivery system. In this review, the concepts, mechanisms, and applications of Nanostructured Lipid Carriers that are considered feasible for transporting macromolecules via transdermal delivery system are thoroughly reviewed and presented along with their clinical perspective.

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