Synthesis and biological evaluation of heterocyclic hydrazone transition metal complexes as potential anticancer agents

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 109718-109725 ◽  
Author(s):  
Yunpeng Du ◽  
Wei Chen ◽  
Xiang Fu ◽  
Hang Deng ◽  
JunGang Deng
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Intracellular Ros ◽  
Synthesis And Biological Evaluation

Only the [Cu(L)2] complex can significantly increase the intracellular ROS levels, leading to relatively high antiproliferative potency.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

2020 ◽  
Vol 26 (41) ◽  
pp. 7452-7475 ◽  
Author(s):  
Marta A. Andrade ◽  
Luísa M.D.R.S. Martins
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Bioinorganic Chemistry ◽  
Chemotherapeutic Agents ◽  
Great Role ◽  
Anticancer Properties ◽  
Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

scholarly journals Synthesis, Characterization and Biological Evaluation of Transition Metal Complexes Derived from N, S Bidentate Ligands

2015 ◽  
Vol 16 (12) ◽  
pp. 11034-11054 ◽  
Author(s):  
Enis Md Yusof ◽  
Thahira Ravoof ◽  
Edward Tiekink ◽  
Abhimanyu Veerakumarasivam ◽  
Karen Crouse ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Biological Evaluation ◽  
Bidentate Ligands

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

scholarly journals Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Shubham Kashyap ◽  
Sanjiv Kumar ◽  
Kalavathy Ramasamy ◽  
Siong Meng Lim ◽  
Syed Adnan Ali Shah ◽  
...  
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Corrosion Inhibition ◽  
Transition Metal Complexes ◽  
Biological Evaluation ◽  
Inhibition Studies

Transition metal complexes of 2, 6-di ((phenazonyl-4-imino) methyl)-4-methylphenol: Structure and biological evaluation

2011 ◽  
Vol 46 (5) ◽  
pp. 1638-1647 ◽  
Author(s):  
Hongyan Liu ◽  
Xiaoyan Shi ◽  
Min Xu ◽  
Zhengpeng Li ◽  
Liang Huang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Biological Evaluation
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